Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(9), P. 1476 - 1480
Published: March 1, 2023
A
ruthenium(II)-catalyzed
one-pot
synthesis
of
highly
substituted
1,2-dihydropyridines
(DHPs)
via
a
three-component
reaction
system
has
been
realized.
The
is
conducted
using
simple
Ru(II)
catalyst
without
the
addition
specific
ligands.
catalytic
exhibits
good
functionality
tolerance
with
wide
range
starting
materials.
DHPs
obtained
can
be
easily
converted
into
tetrahydropyridines
and
azabicyclo[4.2.0]octa-4,7-dienes
by
subsequent
reduction
or
[2
+
2]
cycloaddition
reaction.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(36), P. 7151 - 7187
Published: Jan. 1, 2022
Gold-catalyzed
hydroarylation
reaction
offers
new
pathways
for
producing
complex
organic
compounds
with
diverse
ring
sizes
in
a
highly
regio-
and
stereo-selective
approach
from
available
precursors
like
olefins,
alkynes,
arenes,
aryl
halides.
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(10), P. 8005 - 8012
Published: May 9, 2024
We
report
intra-
and
intermolecular
γ-amino
C(sp3)–H
functionalization
of
aliphatic
amines
using
a
vinylsulfone-based
HAT
(hydrogen
atom
transfer)
auxiliary
triple
catalysis,
which
is
composed
photoredox,
cobalt,
Brønsted
acid
catalysts
under
visible
light
irradiation.
The
process
accomplishes
four
elementary
steps:
(i)
electrophilic
carbon-centered
radical
formation
on
the
via
MHAT
(metal
hydride
hydrogen
reaction,
(ii)
generation
through
1,6-HAT
(iii)
single-electron
oxidation
to
carbocation
equivalents,
(iv)
nucleophilic
substitution
with
internal
or
external
nucleophiles.
As
result,
this
afforded
γ-amino-functionalized
products,
such
as
azetidines,
1,3-diamine,
1,3-aminoalcohol
derivatives.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
We
report
the
electron-deficient
CpRh(III)
[CpERh(III)]
complex-catalyzed
branch
selective
alkenylation
with
aliphatic
alkenes
and
annulation
internal
alkynes
using
N-2-pyridylanilines.
In
these
reactions,
CpERh(III)
catalyst
is
more
active
than
electron-rich
Cp*Rh(III)
catalyst,
used
commonly
in
C–H
activation,
reactions
proceed
a
catalytic
amount
of
Cu(II)
oxidant
under
air
at
lower
temperatures
conventional
methods.
From
mechanistic
considerations,
steric
repulsion
between
ligand
directing
group
may
be
responsible
for
alkenylation.
Processes,
Journal Year:
2023,
Volume and Issue:
11(6), P. 1837 - 1837
Published: June 17, 2023
Herein,
we
report
the
synthesis
of
four
new
hybrid
molecules
between
ketoprofen
or
2-(3-benzoylphenyl)propanoic
acid
and
N-containing
heterocyclic
compounds,
such
as
piperidine,
pyrrolidine,
1,2,3,4-tetrahydroquinoline,
1,2,3,4-tetrahydroisoquinoline.
The
obtained
compounds
were
fully
characterized
using
1H-
13C-NMR,
UV-Vis,
HRMS
spectra.
Detailed
analysis
is
provided
for
all
novel
molecules.
assessed
their
in
vitro
anti-inflammatory
antioxidant
activity.
lipophilicity
hybrids
was
determined,
both
theoretically
(cLogP)
experimentally
(RM).
affinity
to
human
serum
albumin
silico
by
molecular
docking
study
two
software,
stability
predicted
complexes
evaluated
dynamics
study.
All
have
shown
very
good
HPSA
activity,
statistically
close
when
compared
reference—quercetin.
confirmed
results.
Tetrahydroquinoline
derivative
3c
tetrahydroisoquinoline
3d
highest
albumin.
They
show
stronger
action
than
predecessor,
regularly
used
ibuprofen.
Asian Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
11(7)
Published: May 31, 2022
Abstract
Organic
azides
have
been
proven
to
possess
versatile
reactivity
that
is
utilized
synthesize
a
large
number
of
molecular
scaffolds.
Among
the
azides,
α
‐azidoketones
and
esters
widely
explored
numerous
high
valued
N
‐heterocycles.
The
enhanced
acidity
methylene
hydrogen
atoms
by
adjacent
carbonyl
or
ester
groups
α‐azidoketones
largely
attributes
their
unique
chemical
behaviour.
It
has
mostly
in
two
ways:
a)
directly
treated
with
other
reagents
basic
medium
b)
they
are
converted
into
‐azidovinylketones
through
Knoevenagel
condensation
aldehydes
subsequently
various
access
nitrogen
heterocycles.
This
review
provides
general
outlook
concise
report
on
towards
synthesis
‐heterocycles
such
as
pyrroles,
indoles,
pyrazoles,
imidazoles,
triazoles,
pyridines,
pyrimidine,
pyrazine
many
others.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(14), P. 1979 - 1982
Published: Jan. 1, 2023
An
efficient
method
for
the
synthesis
of
isoquinolinone
derivatives
via
photopromoted
carboamination
alkynes
is
developed.
Starting
from
readily
available
propargyl
alcohol
derivatives,
polycyclic
could
be
obtained
with
good
aryl
and
heterocycle
tolerance.
Both
terminal
alkyl
substituted
employed.
This
protocol
operationally
easy,
easily
conducted
on
a
gram-scale.
A
possible
mechanism
involving
radical
addition
cyclization
following
aromatization
was
proposed.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(17), P. 12738 - 12743
Published: Aug. 23, 2023
Herein,
a
straightforward
synthetic
approach
for
the
construction
of
phenanthridin-6(5H)-one
skeletons
is
disclosed.
The
developed
protocol
relies
on
palladium
catalysis,
providing
controlled
access
to
range
functionalized
phenanthridin-6(5H)-ones
in
59-88%
yields.
Furthermore,
plausible
reaction
pathways
are
proposed
based
mechanistic
experiments.
