European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 13, 2023
Abstract
Quinobenzazepines
are
useful
in
medicinal
chemistry,
but
their
synthesis
is
very
challenging.
Herein,
we
designed
and
synthesized
a
range
of
multi‐functional
chalcone‐based
quinolinium
salts;
synthetic
application
the
rapid
straightforward
construction
quinobenzazepines
was
successfully
explored.
A
wide
oxa‐bridged
quinobenzazepine
polycycles
were
afforded
serendipitously
through
dearomative
cascade
reaction
our
newly
developed
salts
acetylacetone.
This
strategy
features
high
bond‐
ring‐forming
efficiency
complete
regio‐
diastereoselective
control.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(48), P. 14213 - 14225
Published: Jan. 1, 2022
This
Perspective
outlines
the
myriad
of
products
that
can
be
obtained
by
dearomatisation
and
functionalization
heteroarene
substrates.
Complex
3D
molecules
often
prepared
in
one
step
from
simple
arene
starting
materials.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8420 - 8434
Published: June 5, 2024
An
elegant
and
highly
concise
strategy
for
the
construction
of
coumarin-functionalized
pyrrolo[2,1-a]isoquinolines
from
available
propargylamines
isoquinolinium
N-ylides
has
been
disclosed.
In
this
reaction,
acted
as
a
C2
synthon
to
form
coumarin
ring
well
1,3-dipole
construct
pyrrole
in
single
pot.
This
cascade
process
involves
1,4-conjugate
addition/lactonization/1,3-dipolar
cycloaddition
four
chemical
bonds
(one
C–O
bond
three
C–C
bonds)
two
new
heterocyclic
skeletons.
Additionally,
most
these
compounds
showed
good
fluorescence
properties
exhibited
high
molar
extinction
coefficient
large
Stokes
shifts.
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(8)
Published: June 21, 2023
Abstract
Indole
heterocycles
hold
an
important
position
in
chemical
landscape
because
of
their
prominence
natural
products
and
pharmaceuticals.
Consequently,
development
new
efficient
strategies
to
access
indole
scaffold
are
continuous
interest.
For
the
past
few
years,
gold‐catalyzed
activation
alkyne
has
emerged
as
a
powerful
strategy
for
constructing
heterocyclic
skeleton.
The
present
review
highlights
recent
advances
(2018–2023)
toward
synthesis
skeletons
via
annulations
alkynes.
A
variety
alkynes,
such
as,
ynamides,
azido
ortho
‐alkynyl
anilines,
propargylic
alcohols,
phenylimines,
miscellaneous
alkynes
employed
affording
various
architectures
under
gold
catalysis.
Moreover,
mechanisms
included
most
cases
better
understanding
reaction
pathway.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(30), P. 4068 - 4071
Published: Jan. 1, 2024
A
two
step
one-pot
annulation
of
donor–acceptor
cyclopropanes
with
tetrahydroisoquinolines
has
been
accomplished
to
furnish
benzo-fused
indolizines
substrate
scope
and
functional
group
diversity.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(5), P. 1173 - 1181
Published: Jan. 1, 2023
Catalytic
isoquinoline-based
EDA
complex
photoreduced
alkylative
[3
+
2]
annulation
of
alkynes
with
N
-alkyl
isoquinolin-2-iums
toward
pyrrolo[2,1-
a
]isoquinolines
is
depicted.
