European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 13, 2023
Abstract
Quinobenzazepines
are
useful
in
medicinal
chemistry,
but
their
synthesis
is
very
challenging.
Herein,
we
designed
and
synthesized
a
range
of
multi‐functional
chalcone‐based
quinolinium
salts;
synthetic
application
the
rapid
straightforward
construction
quinobenzazepines
was
successfully
explored.
A
wide
oxa‐bridged
quinobenzazepine
polycycles
were
afforded
serendipitously
through
dearomative
cascade
reaction
our
newly
developed
salts
acetylacetone.
This
strategy
features
high
bond‐
ring‐forming
efficiency
complete
regio‐
diastereoselective
control.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(4), P. 798 - 803
Published: Jan. 22, 2024
A
(3+2)
cycloaddition
of
heteroaromatic
N-ylides
with
sulfenes,
which
are
generated
in
situ
from
sulfonyl
chlorides,
has
been
developed.
variety
ylides
were
transformed
into
the
corresponding
sulfone-embedded
N-fused
heterocycles
high
yields.
Hexafluoroisopropyl
mesylate
was
demonstrated
to
be
a
suitable
reactant
for
quinolinium
ylides.
Furthermore,
this
could
performed
an
ylide
prepared
by
Cu-catalyzed
transfer
reaction
one-pot
manner,
extending
substrate
scope
unisolable
ylide.
RSC Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
14(12), P. 2509 - 2534
Published: Jan. 1, 2023
This
review
will
be
an
essential
toolbox
for
medicinal
and
bioorganic
chemists
seeking
novel
multifunctional
hybrid
bioactive
N-heterocycles
drug
discovery.
The
work
highlights
the
need
relevance
of
unexplored
bioisosterism
employing
isoquinoline-based
small-molecules
in
design.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
366(2), P. 241 - 247
Published: Nov. 24, 2023
Abstract
The
established
strategy
unveils
a
metal
and
mediator‐free
electrochemical
[3+2]
cycloaddition
approach
among
α
‐amino
carbonyls
tosylmethyl
isocyanide
(TosMIC)
fabricating
substituted
imidazole
scaffolds.
Implementation
of
electro‐redox
conditions
on
this
eliminates
the
essential
requirement
transition
catalysts
chemical
oxidants.
A
wide
variety
different
functionalities
are
well
tolerated
under
reaction
condition,
contributing
to
substrate
scope
applicability.
Several
control
experiments
cyclic
voltammetry
studies
suggest
an
electro‐oxidation
triggered
successive
C−C
C−N
bond
formations
followed
by
rapid
aromatization
for
constructing
five‐membered
core
structure.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(49), P. 27080 - 27088
Published: Nov. 30, 2023
Allenes
are
important
building
blocks,
and
derivatization
of
products
via
cycloadditions
allenes
could
become
a
powerful
strategy
for
constructing
carbocyclic
heterocyclic
rings.
However,
the
development
catalytic
site-selective
enantioselective
cycloaddition
reactions
still
presents
significant
challenges.
Here,
we
report
chiral
π-Cu(II)-complex-catalyzed
isomerization
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(28), P. 10926 - 10934
Published: Jan. 1, 2024
We
report
a
dearomative
(3
+
2)
cycloaddition
between
isoquinolinium
ylides
and
enamides,
dienamides,
or
trienamide,
which
is
catalyzed
by
chiral
π–Cu(
ii
)
complex
proceeds
in
site-selective,
exo
/
endo
-selective,
enantioselective
manner.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(19), P. 13544 - 13552
Published: Sept. 12, 2023
An
Rh(III)-catalyzed
one-pot
synthesis
of
5H-isochromeno[3,4-c]isoquinolines
from
readily
available
4-diazoisochroman-3-imines
and
(2-formylphenyl)boronic
acids
is
reported.
The
cascade
annulation
involves
a
cross-coupling
an
intramolecular
nucleophilic
addition–elimination
process.
A
series
biologically
important
were
obtained
in
good
to
excellent
yields.
method
can
be
extended
synthesize
7H-isochromeno[3,4-b]thieno[3,2-d]pyridines
7H-isochromeno[3,4-b]thieno[2,3-d]pyridines
the
corresponding
heteroaryl
boronic
acids.
