The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(10), P. 6832 - 6837
Published: May 2, 2022
In
this
computational
study,
we
provide
a
detailed
analysis
of
the
underlying
reaction
mechanism
and
show
that
singlet
carbene
is
initially
formed.
Depending
on
pKA
alcohol,
can
engage
in
direct
protonation
or
enol
formation
to
yield
O-H
functionalization
product.
On
contrary,
propargylic
alcohols
take
up
dual
role
form
complex
with
intermediate
leads
facile
cyclopropenation
reactions.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(10), P. 4926 - 4975
Published: Jan. 1, 2024
In
search
for
the
perfect
wave(length).
This
review
is
dedicated
to
recent
efforts
in
development
of
visible
light
driven
photochemical
strategies
occurring
coloured
organic
compounds.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(13), P. 3486 - 3492
Published: Jan. 1, 2022
A
metal-free
and
visible-light-promoted
strategy
has
been
developed
for
the
synthesis
of
S
-alkyl
dithiocarbamates
through
multicomponent
reactions
α-diazoesters,
amines
CS
2
.
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(18), P. 11129 - 11136
Published: Aug. 30, 2022
Herein,
we
report
visible
light
and
N-heterocyclic
carbene
(NHC)
jointly
promoted
multicomponent
transfer
reactions.
Under
the
optimized
reaction
conditions,
two
kinds
of
important
hydroxamic
acid
esters
were
obtained
in
good
yields
depending
on
media
used.
The
key
to
this
success
was
driven
by
blue
light-promoted
generation
free
species
fast
situ
formation
under
NHC-catalyzed
conditions.
mild
excellent
functional
group
tolerance,
useful
synthetic
transformations,
successful
modification
natural
products
drug
molecules
proved
utility
practicality
method.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(1), P. 169 - 173
Published: Jan. 5, 2023
Cyclopropane-fused
lactones
are
highly
desirable
in
drug
and
natural
products
synthesis.
Herein,
we
report
on
a
photochemical,
chemoselective
reaction
of
aryldiazoacetates
with
allylic
alcohols
that
furnishes
cyclopropane-fused
lactone
skeletons
efficiently
one
step.
The
diastereoselectivity
the
protocol
was
precisely
controlled,
cyclopropanation
via
free
carbene
intermediate
followed
by
transesterification
constitutes
series
bicyclic
high
yield
without
formation
ether
byproducts
typical
O–H
insertion
reactions.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(36), P. 6647 - 6652
Published: Sept. 2, 2022
A
visible-light-promoted
three
component
reaction
of
diazo
compounds,
nitriles,
and
carboxylic
acids
is
reported.
The
utilizes
acceptor-only
compounds
as
carbene
precursors
nitriles
carbene-trapping
reagents
to
form
the
key
nitrile
ylides.
Under
optimal
conditions,
a
wide
range
imide
products
were
obtained
in
good
excellent
yields.
gram-scale
synthesis
synthetic
application
isoquinoline-1,3(2H,4H)-dione
derivatives
further
proved
value
this
method.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(6), P. 2816 - 2816
Published: March 21, 2023
As
an
underrepresented
functional
group
in
bioorganic
and
medicinal
chemistry,
the
hydroxylamine
unit
has
historically
received
little
attention
from
synthetic
community.
Recent
developments,
however,
suggest
that
hydroxylamines
may
have
broader
applications
such
a
review
covering
recent
developments
synthesis
of
this
is
timely.
With
mind,
primarily
covers
past
15
years
preparation
di-
trisubstituted
hydroxylamines.
The
mechanism
reactions
key
features
shortcomings
are
discussed
throughout
review.
