Three‐Component Synthesis of 3‐(Arylsulfonyl)benzothiophenes Using Acetic Acid as a Quencher for Methyl Radical‐Mediated Side Reactions

Advanced Synthesis & Catalysis, Journal Year: 2023, Volume and Issue: 365(9), P. 1514 - 1520

Published: March 16, 2023

Abstract A one‐pot, three‐component synthesis of 3‐(arylsulfonyl)benzothiophenes was developed. The reaction did not require any catalysts or additives. desired products were obtained via an intramolecular radical cyclization. Acetic acid employed as the solvent and a quencher for side reactions involving methyl radicals. Moreover, inexpensive potassium metabisulfite used sulfur dioxide surrogate. This process provides more opportunities synthesizing benzothiophene derivatives, which are found in many bioactive compounds. magnified image

Language: Английский

---

Recent Approaches in Transition Metal-Catalyzed Chalcogenative Heteroannulation of Alkenes and Alkynes

Catalysts, Journal Year: 2023, Volume and Issue: 13(9), P. 1300 - 1300

Published: Sept. 16, 2023

Organochalcogen-bearing heterocycles are important scaffolds in compounds under the spotlight of scientific interest optoelectronic fields and for biological applications. The use transition metals has been a versatile reliable way to carry out synthesis these molecules efficiently, delivering products high yields with wide functional diversity. In last 10 years, many classes have synthesized cyclization reaction acyclic alkenes alkynes incorporation chalcogen atom on its structure. Transition metal catalysts including Cu, Co, Pd, Ni, In, Ag, Fe salts used development new methodologies, expansion substrate scope, mechanistic studies. This review provides an overview recent approaches aim being useful resource interested researchers this area.

Language: Английский

---

Catalyst‐Free, One‐Pot, Three‐Component Synthesis of 3‐Arylsulfonylated Thioflavones

Advanced Synthesis & Catalysis, Journal Year: 2022, Volume and Issue: 364(17), P. 3088 - 3093

Published: Aug. 3, 2022

Abstract A one‐pot, three‐component synthesis of 3‐arylsulfonylated thioflavones has been developed. The reactions were carried out without using any catalysts or additives. desired products obtained through intramolecular radical cyclization. This process provides an alternative route for the thioflavone derivatives, which have found in various bioactive compounds. magnified image

Language: Английский

---

Mn‐Mediated Radical Cascade Cyclization of 1,6‐Enynes with Arylboronic Acids to Access Dihydrobenzo[b]fluorenones

Advanced Synthesis & Catalysis, Journal Year: 2022, Volume and Issue: 364(24), P. 4409 - 4414

Published: Dec. 1, 2022

Abstract Herein, we report the synthesis of functionalized dihydro‐benzo[ b ]fluorenones through a manganese‐mediated cascade radical cyclization β ‐alkynyl propenones [1,6‐enynes] with arylboronic acids. In present strategy, in‐situ generated aryl undergoes chemo‐selective addition followed by 5‐ exo‐trig cyclization. The reaction is emphasized high atom‐ and step‐economy construction three new C−C bonds to access dihydrobenzo[ in 68–81% yield under mild conditions. synthetic efficacy developed method evidenced C−N bonds. magnified image

Language: Английский

---

Recent advances in the synthesis of five-membered heterocycles via multicomponent and domino reactions (from 2017 to 2022)

Advances in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 126

Published: Jan. 1, 2023

Language: Английский

---