Exploring faradaic and non-faradaic electrochemical impedance spectroscopy approaches in Parkinson's disease diagnosis DOI Creative Commons

Hussaini Adam,

Subash C. B. Gopinath, Tijjani Adam

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27433 - e27433

Published: March 1, 2024

Parkinson's disease is a neurodegenerative condition defined by the progressive death of dopaminergic neurons in brain. The diagnosis often uses time-consuming clinical evaluations and subjective assessments. Electrochemical Impedance Spectroscopy (EIS) useful technique for electroanalytical devices due to its label-free performance, in-situ measurements, low cost. development reliable diagnostic tools can be significantly enhanced exploring novel techniques like faradaic non-faradaic EIS detection methods. These have ability identify specific biomarkers or changes electrochemical properties linked disease, allowing an early accurate diagnosis. Faradaic methods utilize redox processes on electrode surface, while rely charge transfer capacitive properties. electrical as indicators measuring impedance at different frequencies. By combining both approaches, it may possible obtain comprehensive understanding occurring patients. This lead more effective potentially opening up new avenues personalized treatment strategies. review explores current research approaches diagnosing using spectroscopy.

Language: Английский

Trends in ready-to-use portable electrochemical sensing devices for healthcare diagnosis DOI

Anjana Sajeevan,

Reshmi A. Sukumaran,

Lakshmi R. Panicker

et al.

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)

Published: Jan. 14, 2025

Language: Английский

Citations

1
Electrochemical biosensor based on gold nanoparticles/laser induced graphene for diagnosis of Parkinson’s disease by detecting phosphorylated α-synuclein in human blood DOI Creative Commons
Seongeun Jeong, Sangheon Park, Seungmin Lee

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161329 - 161329

Published: March 1, 2025

Language: Английский

Citations

1
Electrochemical Biosensors for the Detection of Exosomal microRNA Biomarkers for Early Diagnosis of Neurodegenerative Diseases DOI Creative Commons

Jiacheng Yu,

Runzhi Zhou,

Shan Liu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Early and precise diagnosis of neurodegenerative disorders like Alzheimer's (AD) Parkinson's (PD) is crucial for slowing their progression enhancing patient outcomes. Exosomal microRNAs (miRNAs) are emerging as promising biomarkers due to ability reflect the diseases' pathology, yet low abundance poses significant detection hurdles. This review article delves into burgeoning field electrochemical biosensors, designed exosomal miRNA biomarkers. Electrochemical biosensors offer a compelling solution, combining sensitivity required detect low-abundance with specificity needed discern profiles distinctive neural pathological states. We explore operational principles these including transduction mechanisms that facilitate detection. The also summarizes advancements in nanotechnology, signal enhancement, bioreceptor anchoring, microfluidic integration improve sensor accuracy. evidence use disease analyzed, focusing on clinical impact, diagnostic precision, obstacles faced practical applications. Their potential point-of-care testing regulatory considerations market entry discussed. Looking toward future, highlights forthcoming innovations might revolutionize early processes. impressive sensitivity, specificity, compatibility, track become instrumental diseases, possibly transforming care prognosis.

Language: Английский

Citations

1
MIL-125-based nanocarrier decorated with Palladium complex for targeted drug delivery DOI Creative Commons
Mojtaba Bagherzadeh, Moein Safarkhani, Mahsa Kiani

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: July 15, 2022

The aim of this work was to provide a novel approach designing and synthesizing nanocomposite with significant biocompatibility, biodegradability, stability in biological microenvironments. Hence, the porous ultra-low-density materials, metal-organic frameworks (MOFs), have been considered MIL-125(Ti) has chosen due its distinctive characteristics such as great biocompatibility good biodegradability immobilized on surface reduced graphene oxide (rGO). Based results, presence transition metal complexes next drug not only can reinforce structure by preparing π-π interaction between ligands but also enhance efficiency preventing spontaneous release. effect utilizing complex beside (Doxorubicin (DOX)) loading, release, antibacterial activity prepared nanocomposites P. aeruginosa S. aureus model bacterium investigated results revealed that theory leads increasing about 200% activity. In addition, uptake, release drug, relative cell viabilities (in vitro vivo) nanomaterials biomaterials discussed. collected data, median size 156.2 nm, their PBS DMEM + 10% FBS screened after 2.880 min, nanocomposite's reached 242.3 516 nm respectively. MTT demonstrated immobilizing PdL DOX an increase more than 15% viability. It is noticeable AST:ALT result under 1.5.

Language: Английский

Citations

32
Multifunctional green synthesized Cu–Al layered double hydroxide (LDH) nanoparticles: anti-cancer and antibacterial activities DOI Creative Commons
Mahsa Kiani, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: June 8, 2022

Abstract Doxorubicin (DOX) is a potent anti-cancer agent and there have been attempts in developing nanostructures for its delivery to tumor cells. The nanoparticles promote cytotoxicity of DOX against cells turn, they reduce adverse impacts on normal safety profile an important topic recently, the green synthesis has obtained much attention preparation biocompatible carriers. In present study, we prepared layered double hydroxide (LDH) doxorubicin delivery. Cu–Al LDH were synthesized by combining Cu(NO 3 ) 2 ·3H O Al(NO ·9H O, then, autoclave at 110. modification with Plantago ovata (PO) was performed finally, loaded onto nanostructures. FTIR, XRD, FESEM employed characterization nanoparticles, confirming their proper synthesis. drug release study revealed pH-sensitive (highest pH 5.5) prolonged due PO modification. Furthermore, MTT assay improved biocompatibility upon showed controlled low towards wide range cell lines. CLSM demonstrated cellular uptake both HEK-293 MCF-7 lines; however, results promising internalizations rather than vivo experiment highlighted histopathological structure kidneys no side effects further potential as nano-scale systems. Finally, antibacterial test toxicity PO-modified Gram-positive -negative bacteria.

Language: Английский

Citations

31
An innovative method for the detection of alpha synuclein, a potential biomarker of Parkinson's disease: quartz tuning fork-based mass sensitive immunosensor design DOI
Münteha Nur Sonuç Karaboğa, Mehmet Altay Ünal, Fikret Arı

et al.

Physical Chemistry Chemical Physics, Journal Year: 2024, Volume and Issue: 26(6), P. 5106 - 5114

Published: Jan. 1, 2024

An innovative biosensing fabrication strategy has been demonstrated for the first time using a quartz tuning fork to develop practical immunosensor sensitive, selective and analysis of alpha synuclein protein.

Language: Английский

Citations

7
An innovative transportable immune device for the recognition of α-synuclein using KCC-1-nPr-CS2 modified silver nano-ink: integration of pen-on-paper technology with biosensing toward early-stage diagnosis of Parkinson's disease DOI Creative Commons
Arezoo Saadati, Hossein Navay Baghban, Mohammad Hasanzadeh

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(13), P. 8810 - 8818

Published: Jan. 1, 2024

Parkinson's disease (PD), the second most frequent neurodegenerative illness, is a neurological ailment that produces unintentional or uncontrolled body movements, which should be diagnosed in its early stages to hinder progression.

Language: Английский

Citations

6
An α-helical peptide-based plasmonic biosensor for highly specific detection of α-synuclein toxic oligomers DOI Creative Commons

Juliana Fátima Giarola,

Jaime Santos, M.‐Carmen Estévez

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1304, P. 342559 - 342559

Published: March 30, 2024

α-Synuclein (αS) aggregation is the main neurological hallmark of a group neurodegenerative disorders, collectively referred to as synucleinopathies, which Parkinson's disease (PD) most prevalent. αS oligomers are elevated in cerebrospinal fluid (CSF) PD patients, standing biomarker for diagnosis. However, methods early detection still lacking. We have recently identified amphipathic 22-residue peptide PSMα3 high-affinity binder toxic oligomers. displayed excellent selectivity and reproducibility, binding with affinities low nanomolar range without detectable cross-reactivity functional monomeric αS. In this work, we leveraged these unique properties design plasmonic-based biosensor direct under label-free conditions. describe integration lab-on-a-chip plasmonic platform suitable point-of-care measurements CSF samples real-time at an affordable cost, providing innovative diagnosis clinic.

Language: Английский

Citations

6
Tau- and α-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases DOI Creative Commons
Andreas Tapia-Arellano,

Pablo Cabrera,

Elizabeth Cortés-Adasme

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 13, 2024

Abstract The use of nanomaterials in medicine offers multiple opportunities to address neurodegenerative disorders such as Alzheimer's and Parkinson's disease. These diseases are a significant burden for society the health system, affecting millions people worldwide without sensitive selective diagnostic methodologies or effective treatments stop their progression. In this sense, gold nanoparticles is promising tool due unique properties at nanometric level. They can be functionalized with specific molecules selectively target pathological proteins Tau α-synuclein Alzheimer’s Parkinson’s disease, respectively. Additionally, these used biomarkers, wherein play key role enhancing signal, even low concentrations present biological samples blood cerebrospinal fluid, thus enabling an early accurate diagnosis. On other hand, act drug delivery platforms, bringing therapeutic agents directly into brain, improving treatment efficiency precision, reducing side effects healthy tissues. However, despite exciting potential nanoparticles, it crucial challenges issues associated medical field before they widely applied clinical settings. It critical ensure safety biocompatibility context central nervous system. Therefore, rigorous preclinical studies needed assess efficacy feasibility strategies patients. Since there scarce sometimes contradictory literature about context, main aim review discuss analyze current state-of-the-art relation delivery, diagnosis, therapy well recent research preclinical, clinical, emerging areas. Graphical

Language: Английский

Citations

6
Piezoelectric Polymeric Foams as Flexible Energy Harvesters: A Review DOI

Manauwar Ali Ansari,

Patcharapon Somdee

Advanced Energy and Sustainability Research, Journal Year: 2022, Volume and Issue: 3(9)

Published: June 15, 2022

Piezoelectric energy harvesters (PEHs) have the potential to power low‐power electronic devices and can advance, self‐powered, autonomous electronics next level. Conventional ceramic‐based piezoelectrics various properties such as fragility, rigidity, toxicity, high density, lack of design flexibility which limit their use in more flexible environments. A ton research has been carried out published on novel piezomaterials, transduction mechanisms, analytical models, electrical circuits improve aspects PEHs. Among these materials, studies polymeric cellular (or foamed) ferroelectrets or piezoelectrets PEHs grown significantly since discovery. Also, very limited short reviews are available covering only few aspects. There is a necessity recognizing past present advances generation technology polymer systems. Herein, broader review almost all conventional recent foam‐based for PEH applications summarized. These piezoelectric systems either bulk, composite, layered, film form be fabricated, depending application conditions, different polymers groups, mainly, polyolefins, polyester, fluoropolymer, others, considered. Their future perspectives also presented discussed.

Language: Английский

Citations

27