Titanium
dioxide
(TiO2)
has
long
been
employed
as
(photo)electrodes
for
reactions
relevant
to
energy
storage
and
re-newable
synthesis.
Proton-coupled
electron
transfer
(PCET)
with
equimolar
amounts
of
protons
electrons
at
the
TiO2
surface
or
within
bulk
structure
lie
center
these
reactions.
Because
a
proton
an
are
thermochemically
equivalent
H-atom,
essentially
H-atom
Ther-modynamics
complex
dependence
on
synthetic
protocol
chemical
history
elec-trode,
reaction
medium,
many
others;
together,
complications
preclude
understanding
thermochemistry
atomic-level
structural
knowledge.
Herein,
we
report
our
success
in
employing
open-circuit
potential
(EOCP)
measurements
quantitatively
determine
structurally
well-defined
Ti-oxo
clusters
colloidally
stabilized
metal–organic
framework
(MOFs),
Ti-MIL-125.
The
free
Ti3+O–H
bond
dissociation
(BDFE),
was
measured
be
68
±
2
kcal
mol-1.
To
best
understanding,
this
is
first
using
EOCP
any
MOFs.
topology,
change
upon
redox
reaction,
BDFE
values
were
further
corroborated
computational
simula-tions.
Furthermore,
comparisons
EOCP-derived
BDFEs
Ti-MIL-125
similar
parameters
literature
suggest
that
should
preferred
method
accurate
calculations.
reported
employ-ing
nanosized
lay
ground
thermochemical
other
colloidal
systems,
which
otherwise
challenging.
Implications
acceptor
MOFs/metal
oxides
discussed.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(43)
Published: Nov. 21, 2023
Abstract
Metal–organic
framework
(MOF)
materials
are
gaining
significant
interest
in
biomedical
research,
owing
to
their
high
porosity,
crystallinity,
and
structural
compositional
diversity.
Their
versatile
hybrid
organic/inorganic
chemistry
endows
MOFs
with
the
capacity
retain
organic
(drug)
molecules,
metals,
gases,
effectively
channel
electrons
photons,
survive
harsh
physiological
conditions
such
as
low
pH,
even
protect
sensitive
biomolecules.
Extensive
preclinical
research
has
been
carried
out
treat
several
pathologies
and,
recently,
integration
other
stents
implants
demonstrated
promising
performance
regenerative
medicine.
However,
there
remains
a
gap
between
MOF
translation
into
clinically
societally
relevant
medicinal
products.
Here,
intrinsic
features
of
outlined
suitability
specific
applications
detoxification,
drug
gas
delivery,
or
(combination)
therapy
platforms
is
discussed.
Furthermore,
examples
how
have
engineered
evaluated
different
medical
indications,
including
cancer,
microbial,
inflammatory
diseases
described.
Finally,
challenges
facing
clinic
critically
examined,
goal
establishing
directions
more
realistic
approaches
that
can
bridge
translational
MOF‐containing
(nano)materials.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(10), P. 7142 - 7156
Published: Jan. 1, 2024
Carbon
nanomaterials
have
attracted
significant
attention
in
the
biomedical
field,
including
for
biosensing,
drug
delivery,
and
tissue
engineering
applications.
Based
on
their
inherent
properties
such
as
unique
structure
high
conductivity,
carbon
can
overcome
current
limitations
research
poor
stability
of
biomolecules,
low
sensitivity
selectivity
biosensors,
difficulty
precise
delivery.
In
addition,
recently,
several
novel
been
integrated
with
to
develop
carbon-based
nanocomposites
application
research.
this
review,
we
discuss
recent
studies
First,
representative
composed
other
nanomaterials.
Next,
applications
field
are
discussed
according
topics
field.
We
engineering.
conclusion,
believe
that
review
provides
potential
applicability
suggests
future
directions
Materials & Design,
Journal Year:
2023,
Volume and Issue:
233, P. 112252 - 112252
Published: Aug. 18, 2023
Various
wounds
caused
by
burns,
trauma,
surgery,
and
genetic
irregularities,
including
acute
chronic
wounds,
pose
a
huge
burden
on
global
healthcare.
Many
therapeutic
strategies,
such
as
nanomedicine
regenerative
medicine,
have
been
applied
to
wound
repair
skin
regeneration.
As
promising
exciting
nanomaterial,
metal-organic
frameworks
(MOFs)
encompass
many
desirable
properties,
crystalline
porous
structure,
tunable
size,
good
mechanical
stability,
large
specific
surface
area,
exceptional
chemical
stability.
Most
importantly,
the
performance
of
MOFs
can
be
modulated
changing
synthesis
steps
conditions.
release
metal
ions
modulate
cellular
behaviors
kill
various
microorganisms,
which
meets
this
dual
agent
strategy
for
healing
Additionally,
act
carriers
delivering
bioactive
agents
in
desired
manner.
Recently,
an
increasing
number
researchers
conducted
studies
applying
Based
this,
we
perform
study
report
current
status
further
perspective
MOFs-based
strategy.
Furthermore,
molecular
process
fabrication
were
also
discussed.
ACS Applied Engineering Materials,
Journal Year:
2023,
Volume and Issue:
1(11), P. 3080 - 3098
Published: Nov. 6, 2023
This
perspective
presents
an
exploration
of
MXenes
and
metal–organic
frameworks
(MOFs)
in
diverse
applications
such
as
biomedical,
electronics,
sensing
based
on
their
structural
properties.
The
inherent
design
synthesis
flexibility,
sharp
edges,
reactive
oxygen
species
generation,
photothermal
properties
might
be
exploited
for
further
enhancement
these
magic
compounds'
applicability.
On
the
other
hand,
MOFs
demonstrate
potential
various
fields
like
storage,
delivery,
catalysis
owing
to
large
surface/volume
ratio
porosity.
Despite
certain
limitations,
including
poor
electrical
conductivity
MXenes,
recent
studies
suggest
that
MXene@MOF
composites
can
address
major
challenge,
leading
development
highly
sensitive
selective
sensors
a
range
chemical
biological
species.
underscores
amalgamation
yield
synergetic
effect,
thereby
boosting
materials
antimicrobial
applications.
Moreover,
with
rapid
progression
nanotechnology,
are
expected
witness
increasing
usage
sectors,
energy
electronics.
Nonetheless,
required
fully
understand
human
health
environmental
impacts
materials,
several
obstacles,
scalability
manufacturing
processes,
stability,
repeatability
properties,
must
addressed.
MXene@MOFs
present
compelling
area
research
immense
transformative
across
numerous
sectors.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(5), P. 1806 - 1815
Published: April 24, 2023
An
effective
treatment
for
hormone-dependent
breast
cancer
is
chemotherapy
using
cytotoxic
agents
such
as
letrozole
(LTZ).
However,
most
anticancer
drugs,
including
LTZ,
are
classified
class
IV
biopharmaceuticals,
which
associated
with
low
water
solubility,
poor
bioavailability,
and
significant
toxicity.
As
a
result,
developing
targeted
delivery
system
LTZ
critical
overcoming
these
challenges
limitations.
Here,
biodegradable
LTZ-loaded
nanocarriers
were
synthesized
by
solvent
emulsification
evaporation
nanomicelles
prepared
dodecanol-polylactic
acid-co-polyethylene
glycol
(DPLA-co-PEG).
Furthermore,
cell-targeting
folic
acid
(FA)
was
conjugated
into
the
to
achieve
more
safer
treatment.
During
our
investigation,
DPLA-co-PEG
DPLA-co-PEG-FA
displayed
uniform
spherical
morphology.
The
average
diameters
of
86.5
241.3
nm,
respectively.
Our
preliminary
data
suggest
that
both
nanoformulations
cytocompatible,
≥90%
cell
viability
across
all
concentrations
tested.
In
addition,
amphiphilic
nature
led
high
drug
loading
dispersion
in
water,
resulting
extended
release
up
50
h.
According
Higuchi
model,
functionalized
FA
have
greater
potential
controlled
target
cells.
This
model
confirmed
experimentally,
LTZ-containing
significantly
specifically
(up
90%
death)
toward
MCF-7
cells,
human
line,
when
compared
free
DPLA-co-PEG.
half-maximal
inhibitory
concentration
(IC50)
87
±
1
nM
achieved
cells
exposed
DPLA-co-PEG-FA,
whereas
higher
doses
125
2
100
required
DPLA-co-PEG,
Collectively,
represents
promising
nanosized
controllably
drugs
chemotherapeutics.
