Interfacing single-atom catalysis with continuous-flow organic electrosynthesis

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(10), P. 3898 - 3925

Published: Jan. 1, 2022

This manuscript reviews for the first time developments at interface between organic electrosynthesis and single-atom catalysis, highlighting advantages in shifting from a batch to flow production.

Language: Английский

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Recent Progress in Synthetic Applications of Hypervalent Iodine(III) Reagents

Chemical Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Hypervalent iodine(III) compounds have found wide application in modern organic chemistry as environmentally friendly reagents and catalysts. iodine are commonly used synthetically important halogenations, oxidations, aminations, heterocyclizations, various oxidative functionalizations of substrates. Iodonium salts arylating reagents, while iodonium ylides imides excellent carbene nitrene precursors. Various derivatives benziodoxoles, such azidobenziodoxoles, trifluoromethylbenziodoxoles, alkynylbenziodoxoles, alkenylbenziodoxoles group transfer the presence transition metal catalysts, under metal-free conditions, or using photocatalysts photoirradiation conditions. Development hypervalent catalytic systems discovery highly enantioselective reactions chiral represent a particularly recent achievement field chemistry. Chemical transformations promoted by many cases unique cannot be performed any other common, non-iodine-based reagent. This review covers literature published mainly last 7-8 years, between 2016 2024.

Language: Английский

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eFluorination Using Cheap and Readily Available Tetrafluoroborate Salts

Organic Letters, Journal Year: 2023, Volume and Issue: 25(9), P. 1353 - 1358

Published: March 1, 2023

A practical electrochemical method for the rapid, safer, and mild synthesis of tertiary hindered alkyl fluorides from carboxylic acids has been developed without need hydrofluoric acid salts or non-glass reactors. In this anodic fluorination, collidinium tetrafluoroborate acts as both supporting electrolyte fluoride donor. wide range functional groups shown to be compatible, possibility scale-up using flow electrochemistry also demonstrated.

Language: Английский

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Automation and machine learning augmented by large language models in a catalysis study

Chemical Science, Journal Year: 2024, Volume and Issue: 15(31), P. 12200 - 12233

Published: Jan. 1, 2024

AI and automation are revolutionizing catalyst discovery, shifting from manual methods to high-throughput digital approaches, enhanced by large language models.

Language: Английский

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Continuous flow reactions in the preparation of active pharmaceutical ingredients and fine chemicals

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(24), P. 3226 - 3239

Published: Jan. 1, 2024

This feature article presents an overview of continuous flow chemistry, including photoflow and electroflow technologies in the preparation active pharmaceutical ingredients (APIs) fine chemical intermediates.

Language: Английский

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Electrochemical Lactonization Enabled by Unusual Shono-Type Oxidation from Functionalized Benzoic Acids

Organic Letters, Journal Year: 2024, Volume and Issue: 26(9), P. 1936 - 1940

Published: Feb. 26, 2024

A novel method for electrochemical lactonization via C(

Language: Английский

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Antimicrobial Evaluation of New Pyrazoles, Indazoles and Pyrazolines Prepared in Continuous Flow Mode

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5319 - 5319

Published: March 10, 2023

Multi-drug resistant bacterial strains (MDR) have become an increasing challenge to our health system, resulting in multiple classical antibiotics being clinically inactive today. As the de-novo development of effective is a very costly and time-consuming process, alternative strategies such as screening natural synthetic compound libraries simple approach towards finding new lead compounds. We thus report on antimicrobial evaluation small collection fourteen drug-like compounds featuring indazoles, pyrazoles pyrazolines key heterocyclic moieties whose synthesis was achieved continuous flow mode. It found that several possessed significant antibacterial potency against clinical MDR Staphylococcus Enterococcus genera, with (9) reaching MIC values 4 µg/mL those species. In addition, time killing experiments performed 9 aureus highlight its activity bacteriostatic. Additional evaluations regarding physiochemical pharmacokinetic properties most active are reported showcased, promising drug-likeness, which warrants further explorations newly identified compound.

Language: Английский

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Electrocatalytic continuous flow chlorinations with iodine(I/III) mediators

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 27, 2024

Abstract Electrochemistry offers tunable, cost effective and environmentally friendly alternatives to carry out redox reactions with electrons as traceless reagents. The use of organoiodine compounds electrocatalysts is largely underdeveloped, despite their widespread application powerful versatile Mechanistic data reveal that the hexafluoroisopropanol assisted iodoarene oxidation followed by a stepwise chloride ligand exchange for catalytic generation dichloroiodoarene mediator. Here, we report an benign iodine(I/III) electrocatalytic platform in situ dichloroiodoarenes different such mono- dichlorinations well chlorocyclisations within continuous flow setup.

Language: Английский

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Electrochemical Decarboxylative Elimination of Carboxylic Acids to Alkenes

Organic Letters, Journal Year: 2023, Volume and Issue: 25(43), P. 7816 - 7821

Published: Oct. 23, 2023

An electrochemical strategy for the decarboxylative elimination of carboxylic acids to alkenes at room temperature has been developed. This mild and oxidant-free method provides a green alternative traditional thermal decarboxylation reactions. Structurally diverse aliphatic acids, including biologically active drugs, underwent smooth conversion corresponding in good excellent yields.

Language: Английский

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Recent advances exploiting reactive intermediates generated via continuous flow chemistry

Current Opinion in Green and Sustainable Chemistry, Journal Year: 2024, Volume and Issue: 47, P. 100907 - 100907

Published: March 13, 2024

Reactive intermediates are transient high-energy species playing a pivotal role in the synthesis of organic molecules. Continuous flow processing is frequently exploited generating plethora reactive situ followed by their rapid transformation to target Reactor miniaturisation along with high heat and mass transfer rates key features that these processes provide for additional benefits such as safety scalability. This short review highlights recent advances field chemistry generation use photochemical reactions, low-temperature sequences well related transformations.

Language: Английский

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