Improving the use of CRISPR/Cas9 gene editing machinery as a cancer therapeutic tool with the help of nanomedicine DOI
Hina Fatima, Dimple Singh, H. Muhammad

et al.

3 Biotech, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 19, 2024

Language: Английский

A Semiconducting Polymer NanoCRISPR for Near-Infrared Photoactivatable Gene Editing and Cancer Gene Therapy DOI
Yue Liu, Fei Li, Yan Lyu

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Clustered regularly interspaced short palindromic repeat (CRISPR) gene editing has poor efficacy and off-target side effect concerns. We herein report a semiconducting polymer (SP)-based nanoCRISPR system to improve CRISPR delivery allow for near-infrared (NIR) photoactivatable cancer therapy. An amphiphilic SP acts as photothermal converter, its backbone is grafted with single-stranded deoxyribonucleic acid (DNA), which enables hybridization single guide ribonucleic (sgRNA) via complementary base pairing form sgRNA/SP-DNA. This sgRNA/SP-DNA nanosystem (nanoCRISPR) can effectively deliver sgRNA into cells generate heat under NIR laser irradiation the effect. The localized triggers dissociation of DNA control release sgRNA, thereby achieving precise regulation activity. technology able precisely regulate expression green fluorescent protein (GFP) polo-like kinase 1 (PLK1) precision

Language: Английский

Citations

0
Redefining Hepatocellular Carcinoma Treatment: Nanotechnology Meets Tumor Immune Microenvironment DOI
Chen Mi, Sai Liu, Zhida Chen

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 47

Published: March 13, 2025

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, characterized by its complex pathogenesis and poor therapeutic outcomes. Despite recent advances in targeted molecular therapies, immune checkpoint inhibitors (ICIs), radiotherapy, conventional chemotherapy, five-year survival rate for this neoplasm remains dismally low. The progress nanotechnology has revolutionized cancer treatment years. These provide unprecedented opportunities to overcome current limitations different modalities. This review provides a comprehensive analysis how interfaces with tumor microenvironment (TIME) HCC can present new frontier interventions HCC. We critically overview latest developments nanoparticle-based delivery systems various drugs also other antitumor agents like thermal therapy radiotherapy. highlight unique ability nanoparticles modulate immunosuppressive (TME) enhance efficacy. Furthermore, we analyze emerging strategies that exploit nanoformulations biological barriers drug bioavailability treatment.

Language: Английский

Citations

0
Plasmid DNA and mRNA delivery: Approaches and challenges DOI
Arun Kumar Singh, Karan Goel, Meenakshi Dhanawat

et al.

Advances in immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Comparative examination of the chemistry and biology of AI-driven gold NPs in Theranostics: New insights into biosensing, bioimaging, genomics, diagnostics, and therapy DOI

Donya Esmaeilpour,

Ehsan Nazarzadeh Zare‬,

Mahnaz Hassanpur

et al.

Nanomedicine Nanotechnology Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 102821 - 102821

Published: April 1, 2025

Language: Английский

Citations

0
Improving the use of CRISPR/Cas9 gene editing machinery as a cancer therapeutic tool with the help of nanomedicine DOI
Hina Fatima, Dimple Singh, H. Muhammad

et al.

3 Biotech, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 19, 2024

Language: Английский

Citations

3