Roadmap to the Synthesis of Nickel Bisoxazoline Aryl Halide Complexes DOI

Brennan D. McManus,

Olivia R. Taylor,

Nathan J. Coddington

et al.

Organometallics, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Language: Английский

Mechanisms of Photoredox Catalysis Featuring Nickel–Bipyridine Complexes DOI Creative Commons
David A. Cagan, Daniel Bím, Nathanael P. Kazmierczak

et al.

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(11), P. 9055 - 9076

Published: May 29, 2024

Metallaphotoredox catalysis can unlock useful pathways for transforming organic reactants into desirable products, largely due to the conversion of photon energy chemical potential drive redox and bond transformation processes. Despite importance these processes cross-coupling reactions other transformations, their mechanistic details are only superficially understood. In this review, we have provided a detailed summary various photoredox mechanisms that been proposed date Ni-bipyridine (bpy) complexes, focusing separately on photosensitized direct excitation reaction By highlighting multiple key findings, depict how mechanisms, which ultimately define substrate scope, themselves defined by ground- excited-state geometric electronic structures Ni-based intermediates. We further identify knowledge gaps motivate future studies development synergistic research approaches spanning physical, organic, inorganic chemistry communities.

Language: Английский

Citations

24

Electrocatalytic Formal C(sp2)−H Alkylations via Nickel‐Catalyzed Cross‐Electrophile Coupling with Versatile Arylsulfonium Salts DOI Creative Commons
Takuya Michiyuki, Simon L. Homölle, Neeraj Kumar Pandit

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(29)

Published: May 2, 2024

Producing sp

Language: Английский

Citations

11

Alkyl Cyclopropyl Ketones in Catalytic Formal [3 + 2] Cycloadditions: The Role of SmI2 Catalyst Stabilization DOI Creative Commons
Jack I. Mansell, Song Yu,

Mu-Ze Li

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(18), P. 12799 - 12807

Published: April 25, 2024

Alkyl cyclopropyl ketones are introduced as versatile substrates for catalytic formal [3 + 2] cycloadditions with alkenes and alkynes previously unexplored enyne partners, efficiently delivering complex, sp3-rich products. The key to effectively engaging this relatively unreactive new substrate class is the use of SmI2 a catalyst in combination substoichiometric amounts Sm0; latter likely acting prevent deactivation by returning SmIII cycle. In absence Sm0, background degradation can outrun product formation. For most recalcitrant alkyl ketones, catalysis "switched-on" using these robust conditions, otherwise unattainable products delivered. Combined experimental computational studies have been used identify probe reactivity trends among including more complex bicyclic which react quickly various partners give addition establishing burgeoning field catalysis, our study provides vital mechanistic insight robust, practical approaches nascent SmI2.

Language: Английский

Citations

9

Dynamic stereomutation of vinylcyclopropanes with metalloradicals DOI Creative Commons
Marvin Mendel, Teresa M. Karl,

Jegor Hamm

et al.

Nature, Journal Year: 2024, Volume and Issue: 631(8019), P. 80 - 86

Published: June 19, 2024

Abstract The ever increasing demands for greater sustainability and lower energy usage in chemical processes call fundamentally new approaches reactivity principles. In this context, the pronounced prevalence of odd-oxidation states less precious metals bears untapped potential distinct modes via metalloradical catalysis 1–3 . Contrary to well-established paradigm that organic free radicals, upon addition a vinylcyclopropane, lead rapid ring opening under strain release—a transformation serves widely as mechanistic probe (radical clock) 4 intermediacy radicals 5 —we herein show metal-based radical, is, Ni (I) metalloradical, triggers reversible cis / trans isomerization instead opening. proceeds chiral inversion and, depending on substitution pattern, occurs at room temperature than min, requiring solely non-precious catalyst. Our combined computational experimental studies support origin profound reactivity, rationalize observed stereoinversion reveal key features process, including its reversibility. These insights enabled iterative thermodynamic enrichment enantiopure mixtures towards single diastereomer through multiple rounds also extensions divinylcyclopropanes, which constitute strategic motifs natural product- total syntheses 6 While -isomer usually requires heating approximately 200 °C trigger thermal racemization -divinylcyclopropane, then undergoes facile Cope-type rearrangement, analogous contra-thermodynamic process is shown proceed mild conditions without any loss stereochemical integrity, enabling stereochemically pure access seven-membered rings, fused systems spirocycles.

Language: Английский

Citations

9

Light Activation and Photophysics of a Structurally Constrained Nickel(II)–Bipyridine Aryl Halide Complex DOI
Daniel Bím, Kaitlin M. Luedecke, David A. Cagan

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(9), P. 4120 - 4131

Published: Feb. 20, 2024

Transition-metal photoredox catalysis has transformed organic synthesis by harnessing light to construct complex molecules. Nickel(II)–bipyridine (bpy) aryl halide complexes are a significant class of cross-coupling catalysts that can be activated via direct excitation. This study investigates the effects molecular structure on photophysics these considering an underexplored, structurally constrained Ni(II)–bpy in which and bpy ligands covalently tethered alongside traditional unconstrained complexes. Intriguingly, is photochemically stable but features reversible Ni(II)–C(aryl) ⇄ [Ni(I)···C(aryl)•] equilibrium upon photoexcitation. When electrophile introduced during photoirradiation, we demonstrate preference for photodissociation over recombination, rendering parent Ni(II) source reactive Ni(I) intermediate. Here, characterize photochemical behavior kinetic analyses, quantum chemical calculations, ultrafast transient absorption spectroscopy. Comparison previously characterized indicates structural constraints considered here dramatically influence excited state relaxation pathway provide insight into characteristics excited-state Ni(II)–C bond homolysis radical reassociation dynamics. enriches understanding offers new possibilities designing customized photoactive precise synthesis.

Language: Английский

Citations

7

Electrochemical Nickel-Catalyzed C(sp2)-H Functionalization of Tropones with Aldehydes DOI Creative Commons
Andrea Brunetti, Sofia Kiriakidi,

Mauro Garbini

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 3184 - 3190

Published: Feb. 6, 2025

A direct electroreductive functionalization of tropones employing aldehydes as alkylating agents is reported. This C(sp2)-H process leverages the mediation electroactive nickel complexes, enabling a wide range both native and substituted (44 examples) to be alkylated selectively at α-position in high yields (up 90%). Combined electrochemical, spectroelectrochemical, computational analyses disclosed whole mechanistic pathway revealed key role played by reduced Ni complexes activating tropone core toward condensation with aldehydes.

Language: Английский

Citations

1

Late-Stage C(sp2)–C(sp3) Diversification via Nickel Oxidative Addition Complexes DOI
Carlota Odena, Tomás G. Santiago,

María Lourdes Linares

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(31), P. 21264 - 21270

Published: July 25, 2024

Herein, we describe nickel oxidative addition complexes (Ni-OACs) of drug-like molecules as a platform to rapidly generate lead candidates with enhanced C(sp3) fraction. The potential Ni-OACs access new chemical space has been assessed not only in C(sp2)–C(sp3) couplings but also additional bond formations without recourse specialized ligands and improved generality when compared Ni-catalyzed reactions. development an automated diversification process further illustrates the robustness Ni-OACs, thus offering gateway expedite design–make–test–analyze (DMTA) cycle drug discovery.

Language: Английский

Citations

6

Ni-catalysed remote C(sp3)–H functionalization using chain-walking strategies DOI
Ciro Romano, Rubén Martı́n

Nature Reviews Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

6

Water and Air Stable Copper(I) Complexes of Tetracationic Catenane Ligands for Oxidative C−C Cross‐Coupling DOI Creative Commons

Man Pang Tang,

Lihui Zhu, Yulin Deng

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(28)

Published: April 25, 2024

Abstract Aqueous soluble and stable Cu(I) molecular catalysts featuring a catenane ligand composed of two dicationic, mutually repelling but mechanically interlocked macrocycles are reported. The interlocking not only fine‐tunes the coordination sphere kinetically stabilizes against air oxidation disproportionation, also buries hydrophobic portions ligands prevents their dissociation which necessary for good water solubility sustained activity. These complexes can catalyze oxidative C−C coupling indoles tetrahydroisoquinolines in water, using H 2 O as green oxidant with substrate scope. successful use exploiting aqueous catalysis thus highlights many unexplored potential mechanical bond design element exploring transition metal under challenging conditions.

Language: Английский

Citations

5

Overcoming Electron Bias in Hydroarylation of Phenylpropiolic Acid Derivatives To Enable Highly Reversed Regio- and Stereoselectivity via Steric and Transient Post Addition Coordination DOI
Hui Li, Xu Tian,

Qin-Qin Dang

et al.

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(13), P. 9985 - 9992

Published: June 19, 2024

The regio- and stereoselective hydroarylation of internal alkynes via transition-metal catalysis offers a direct approach for designing highly stereodefined multifunctionalized olefins. Through recognition electronic bias, β-syn-hydroarylation poor with arylboronic acids has been well studied. However, from the same starting materials, achieving opposite α-selective anti-stereoselective remains significant challenge due to these inherent biases. Therefore, an alternative synthetic pathway trisubstituted alkenes reversed positioning configuration substituents is desirable. Based on steric repulsion-induced regioselectivity transient post-addition coordination-directed stereoselectivity, we report herein α-hydroarylation method phenylpropiolic esters using nickel catalyst that promotes formal anti-addition pathway. A broad range organoboronic acid derivatives are compatible this protocol, offering selectivity traditional reactions. distinct advantages our include precise control over selectivity, reduced loading, tolerance toward functional groups. These features highlight potential in synthesis late-stage modification alkyne-based drug intermediates, showcasing its versatility applicability organic synthesis.

Language: Английский

Citations

4