Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116781 - 116781
Published: April 1, 2025
Language: Английский
Small, Journal Year: 2024, Volume and Issue: 20(22)
Published: Jan. 2, 2024
Abstract Mineralization capable of growing inorganic nanostructures efficiently, orderly, and spontaneously shows great potential for application in the construction high‐performance organic–inorganic composites. As a thermodynamically spontaneous solid‐phase crystallization reaction involving dual organic components, mineralization allows self‐assembly sophisticated exclusive within polymer matrix. It results diversity functions such as enhanced strength, toughness, electrical conductivity, selective permeability, biocompatibility. While there are previous reviews discussing progress reactions, many them overlook significant benefits interfacial regulation functionalization that come from incorporation mineralized structures into polymers. Focusing on different means assembly polymer, work analyzes their design principles implementation strategies. Then, advantages disadvantages analyzed by combining with substrates well basis functionalizations. is anticipated to provide insights guidance future development composites designs.
Language: Английский
Citations
6
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 172, P. 441 - 453
Published: Oct. 4, 2023
Language: Английский
Citations
15
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(52)
Published: Nov. 8, 2023
Supramolecular peptide assemblies have been widely used for the development of biomedical, catalytical, and optical materials with chiral nanostructures in view intrinsic chirality peptides. However, assembly pathway transformation behavior various peptides remain largely elusive especially transient under out-of-equilibrium conditions. Herein, N-fluorenylmethoxycarbonyl-protected phenylalanine-tyrosine dipeptide (Fmoc-FY) was as a platform, which showed that proceeds multistep evolution. The original spheres caused by liquid-liquid phase separation (LLPS) can nucleate elongate into formation right-handed helices were metastable easily converted microribbons. Interestingly, bipyridine derivative be introduced to effectively control induce thermodynamically stable or left-handed at different stoichiometric ratios. In addition, also regulated ultrasound enzyme catalysis. This minimalistic system not only broadens nucleation-elongation mechanisms protein aggregates but promotes controllable design biomaterials.
Language: Английский
Citations
15
Trends in Chemistry, Journal Year: 2023, Volume and Issue: 5(6), P. 460 - 473
Published: April 25, 2023
Language: Английский
Citations
14
Journal of Chemical Theory and Computation, Journal Year: 2024, Volume and Issue: 20(2), P. 532 - 550
Published: Jan. 11, 2024
With the ongoing development of peptide self-assembling materials, there is growing interest in exploring novel functional sequences. From short peptides to long polypeptides, as functionality increases, sequence space also expanding exponentially. Consequently, attempting explore all sequences comprehensively through experience and experiments alone has become impractical. By utilizing computational methods, especially artificial intelligence enhanced molecular dynamics (MD) simulation de novo design, been a significant expansion exploration space. Through these variety supramolecular including fibers, two-dimensional arrays, nanocages, etc., have designed by meticulously controlling inter- intramolecular interactions. In this review, we first provide brief overview current main methods then focus on design for various self-assembled materials. Additionally, introduce some representative protein self-assemblies offer guidance peptides.
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Biomimetic calcification is a micro‐crystallization process that mimics the natural biomineralization process, where biomacromolecules regulate formation of inorganic minerals. In this study, it presented protein‐assisted biomimetic method for in situ synthesis nitrogen‐doped metal‐organic framework (MOF) materials. A series unique core‐shell structures are created by utilizing proteins as templates and guiding agents nucleation step, creating ideal conditions shell growth. To further understand influence protein organic ligand on morphology MOF shell, competing mechanism toward metal ions supposed. Through systematic experiments analyses, strategy to construct precursor controlling proposed. After carbonization, protein‐containing precursors exhibit exceptional porous characteristics, stability, high nitrogen content. These attributes make them promising materials sulfur hosts lithium‐sulfur batteries (LSB). Electrochemical tests confirm calcification‐assisted 3D carbonaceous structure can effectively immobilize dissolved polysulfides, demonstrating strong adsorption catalytic capabilities. This discovery not only opens up new avenues employing sustainable but also enlightens fields science, chemistry, energy storage.
Language: Английский
Citations
0
Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Immunotherapy has attracted widespread attention because of its durable and effective antitumor properties. However, systemic delivery strategies often result in immune-related off-target toxicity effects inadequate drug retention at the tumor site, which limits broader application. In this research, we designed a dual-functional peptide (N-Pep) that serves as both therapeutic agent metal ions (Mn2+) immunomodulator carrier. The rational self-assembles into hydrogel through coordination with Mn2+ (referred to N-Pep-Mn gel). multiporous network allows for efficient loading antiprogrammed death-1 antibody (αPD-1). served depot sustained release encapsulated αPD-1, effectively activating dendritic cells, polarizing tumor-associated macrophages enhancing effector T cell infiltration, thereby leading inhibition growth intratumoral immune responses. Additionally, induces robust memory, providing substantial protection against recurrence. These findings underscore potential ion-coordinated an advanced platform immunotherapy.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141449 - 141449
Published: Feb. 25, 2025
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Non-alcoholic fatty liver disease (NAFLD)-induced early-stage fibrosis is increasingly common. Non-invasive MRI detection offers an important diagnostic method to prevent from progressing cirrhosis or hepatocellular carcinoma. However, because confined the periportal areas, and changes in tissue structure stiffness are minimal, standard T1- T2-weighted imaging struggles capture these lesions. To address this challenge, a highly sensitive targeted T1-T2 dual-mode magnetic resonance (MRI) nanoprobe designed developed, specifically targeting characterized by activation of hepatic stellate cells (HSCs) overexpression platelet-derived growth factor receptor β (PDGFRβ). The exhibits excellent relaxivity (r2/r1 = 10.7) precise due PDGFRβ-specific peptides conjugated its protein nanocage. In vivo, animal models demonstrate effective accumulation probe fibrotic regions as NAFLD progressed, with fluorescence signal intensity accurately reflecting severity fibrosis. Using 7T system, T1 T2 images overlaid within 1 h, locating areas improving speed precision. shows biocompatibility enhances early NAFLD, offering significant clinical potential for diagnosis, prognosis, recurrence monitoring.
Language: Английский
Citations
0
Applied Materials Today, Journal Year: 2025, Volume and Issue: 44, P. 102676 - 102676
Published: March 15, 2025
Language: Английский
Citations
0