Light‐activated Nanocatalyst for Precise In‐situ Antimicrobial Synthesis via Photoredox‐Catalytic Click Reaction DOI
Minyang Zhao,

Lei Cao,

Qingqing Bai

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(41)

Published: July 16, 2024

The excessive and prolonged use of antibiotics contributes to the emergence drug-resistant S. aureus strains potential dysbacteriosis-related diseases, necessitating exploration alternative therapeutic approaches. Herein, we present a light-activated nanocatalyst for synthesizing in situ antimicrobials through photoredox-catalytic click reaction, achieving precise, site-directed elimination skin infections. Methylene blue (MB), commercially available photosensitizer, was encapsulated within Cu

Language: Английский

Radiotherapy activates picolinium prodrugs in tumours DOI
Qunfeng Fu, 知子 谷, Siyong Shen

et al.

Nature Chemistry, Journal Year: 2024, Volume and Issue: 16(8), P. 1348 - 1356

Published: April 1, 2024

Language: Английский

Citations

22
Radiopharmaceuticals and their applications in medicine DOI Creative Commons
Siqi Zhang, Xingkai Wang, Xin Gao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 2, 2025

Abstract Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for diagnosis and treatment multiple diseases. Radiopharmaceutical therapy, which directly causes systematic irreparable damage cells, has attracted increasing attention in refractory diseases that are not sensitive current therapies. As Food Drug Administration (FDA) approvals [ 177 Lu]Lu-DOTA-TATE, Lu]Lu-PSMA-617 their complementary diagnostic agents, namely, 68 Ga]Ga-DOTA-TATE Ga]Ga-PSMA-11, radiopharmaceutical-based theranostics (radiotheranostics) being increasingly implemented clinical practice oncology, lead a new era radiopharmaceuticals. The generation radiopharmaceuticals utilizes targeting vector achieve accurate avoid off-target deposition, making it possible improve efficiency biosafety tumour therapy. Numerous studies have focused on developing novel broader range disease targets, demonstrating remarkable vivo performance. These include high tumor uptake, prolonged retention time, favorable pharmacokinetic properties align with standards. While radiotheranostics been widely applied applications now expanding neurodegenerative diseases, cardiovascular inflammation. Furthermore, radiotheranostic-empowered precision medicine is revolutionizing cancer paradigm. Diagnostic play pivotal role patient stratification planning, leading improved therapeutic outcomes radionuclide This review offers comprehensive overview evolution radiopharmaceuticals, including both FDA-approved clinically investigated explores mechanisms cell death induced by It emphasizes significance future prospects theranostic-based advancing medicine.

Language: Английский

Citations

4
Nitric Oxide‐Activated Bioorthogonal Codelivery Nanoassembly for In Situ Synthesis of Photothermal Agent for Precise and Safe Anticancer Treatment DOI
Bowen Li,

Jianwu Tian,

Chongzhi Wu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 17, 2024

The development of bioorthogonal activation in drug release represents a promising avenue for precise and safe anticancer treatment. However, two significant limitations currently hinder their clinical application: i) the necessity separate administration precursor its corresponding activator, leading to poor accumulation potential side effects; ii) reliance on exogenous metal or organic activators triggering activation, which often exhibit low efficiency systemic toxicity when extending living animals. To overcome these limitations, nitric oxide (NO)-mediated codelivery nanoassembly, termed TTB-NH

Language: Английский

Citations

9
Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment DOI Creative Commons
Yilin Chen, Zi Ye, Haixu Chen

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4021 - 4040

Published: May 1, 2024

Abstract: Cataract is a leading cause of blindness globally, and its surgical treatment poses significant burden on global healthcare. Pharmacologic therapies, including antioxidants protein aggregation reversal agents, have attracted great attention in the cataracts recent years. Due to anatomical physiological barriers eye, effectiveness traditional eye drops for delivering drugs topically lens hindered. The advancements nanomedicine present novel promising strategies addressing challenges drug delivery lens, development nanoparticle formulations that can improve penetration into anterior segment enable sustained release medications. This review introduces various cutting-edge systems cataract treatment, highlighting their physicochemical properties surface engineering optimal design, thus providing impetus further innovative research potential clinical applications anti-cataract drugs. Keywords: nanomedicine, cataract, ocular barrier, system

Language: Английский

Citations

8
Prodrug-based bispecific antibodies for cancer therapy: advances and future directions DOI Creative Commons

Zhengdong Ai,

Bing Wang,

Yunlong Song

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

Bispecific antibodies represent an innovative paradigm in cancer therapy, offering broader therapeutic potential compared to conventional monoclonal antibodies. To increase tumor selectivity while mitigating off-target effects normal tissues, the concept of prodrug-based bispecific has emerged. This review delineates various mechanisms underlying action antibodies, including protease-mediated activation, steric hindrance release via proteolytic processing, activation by soluble factors, conditional assembly, and chain exchange-mediated activation. We also address critical challenges that must be overcome optimize development clinical application these sophisticated agents.

Language: Английский

Citations

1
Cleavage of Homonuclear Chalcogen‐Chalcogen Bonds in a Hybrid Platform in Response to X‐Ray Radiation Potentiates Tumor Radiochemotherapy DOI Open Access

Yuanyuan You,

Yanzhou Chang,

Shuya Pan

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Aug. 23, 2024

Chalcogens are used as sensitive redox-responsive reagents in tumor therapy. However, chalcogen bonds triggered by external ionizing radiation, rather than internal environmental stimuli, enable site-directed and real-time drug degradation target lesions. This approach helps to bypass chemoresistance global systemic toxicity, presenting a significant advancement over traditional chemoradiotherapy. In this study, we fabricated hybrid monodisperse organosilica nanoprodrug based on homonuclear single (disulfide (S-S, approximately 240 kJ/mol), diselenium (Se-Se, 172 tellurium (Te-Te, 126 kJ/mol)), including ditelluride-bond-bridged MONs (DTeMSNs), diselenide-bond-bridged (DSeMSNs) disulfide-bond-bridged (DSMSNs). The results demonstrated that differences electronegativities atomic radii influenced their oxidation sensitivities reactivities. Tellurium, with the lowest electronegativity, showed highest sensitivity, followed selenium sulfur. DTeMSNs exhibited highly responsive cleavage upon exposure X-rays, resulting TeO

Language: Английский

Citations

7
Locally unlocks prodrugs by radiopharmaceutical in tumor for cancer therapy DOI

Changlun Wang,

Mengxin Xu, Zihang Zhang

et al.

Science Bulletin, Journal Year: 2024, Volume and Issue: 69(17), P. 2745 - 2755

Published: July 15, 2024

Language: Английский

Citations

6
C−N Coupling between Aryl Azides and Cyclopropanols by Photoredox/Copper Dual Catalysis DOI

Wu‐Jie Lin,

Yu‐Zhao Wang, Wei Yu

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(7), P. 1559 - 1564

Published: Feb. 14, 2024

Abstract A photoredox/copper co‐catalyzed ring‐opening cross‐coupling of aryl azides with cyclopropanols has been developed fac ‐Ir(ppy) 3 as the photocatalyst. The reaction involves intermediacy anilino radical generated through reduction azido group by * and [Cu II ]‐enabled oxidative cyclopropanol. An array β‐aminoketone compounds were synthesized under redox‐neutral conditions using this method.

Language: Английский

Citations

5
A self‐reinforced activatable photosensitizer prodrug enabling synergistic photodynamic and chemotherapy DOI Creative Commons

Daipeng Huang,

Jikai Yin, Yang Zou

et al.

Smart Molecules, Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

Abstract As a novel drug development paradigm, selective activation of prodrugs provides the potential for precise tumor chemotherapy, thereby presenting an opportunity advancing cancer treatment. The combination photodynamic therapy (PDT) and prodrug can enhance therapeutic efficacy while simultaneously enabling real‐time monitoring distribution release. However, hypoxia microenvironment frequent high‐dose administration significantly impede escalate treatment‐related risks. Herein, microenvironment‐specific release is constructed, termed NBS‐2S‐5FU. Under influence glutathione (GSH), NBS‐2S‐5FU undergoes activation, leading to photosensitizer NBS chemotherapeutic agent 5‐FU derivatives. irradiation, produces sufficient superoxide radical () derivatives inhibit DNA biosynthesis, effectively suppressing growth at low doses. Subsequent in vivo studies utilizing liposomes exhibit outstanding anti‐cancer effectiveness. This study highlights promising direction combined that integrate PDT chemotherapy.

Language: Английский

Citations

5
Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously DOI Creative Commons
Kevin R. Venrooij,

Lucienne de Bondt,

Kimberly M. Bonger

et al.

Topics in Current Chemistry, Journal Year: 2024, Volume and Issue: 382(3)

Published: July 6, 2024

Abstract Bioorthogonal click chemistry has played a transformative role in many research fields, including chemistry, biology, and medicine. Click reactions are crucial to produce increasingly complex bioconjugates, visualize manipulate biomolecules living systems for various applications bioengineering drug delivery. As biological (model) grow more complex, researchers have an increasing need using multiple orthogonal simultaneously. In this review, we will introduce the most common bioorthogonal discuss their use on basis of mechanism electronic or steric tuning. We provide overview strategies create reaction orthogonality show recent examples mutual used simultaneous biomolecule labeling. end by discussing some considerations type needed labeling system choice.

Language: Английский

Citations

5