A 2D Porous Zinc-Organic Framework Platform for Loading of 5-Fluorouracil

Inorganics, Journal Year: 2022, Volume and Issue: 10(11), P. 202 - 202

Published: Nov. 9, 2022

A hydrostable 2D Zn-based MOF, {[Zn(5-PIA)(imbm)]·2H2O}n (1) (5-H2PIA = 5-propoxy-isophthalic acid, imbm 1,4-di(1H-imidazol-1-yl)benzene), was synthesized and structurally characterized. Complex 1 shows good water thermal stability based on the TGA PXRD analyses displays a framework with 1D channels of 4.8 × 13.8 10.0 8.3 Å2 along axis. The 5-fluorouracil (5-FU) payload in activated complex (complex 1a) is 19.3 wt%, cumulative release value 5-FU at 120 h about 70.04% PBS (pH 7.4) 310 K. In vitro MTT assays did not reveal any cytotoxic effect NIH-3T3 HEK-293 cells when concentration below 500 μg/mL 5 μg/mL, respectively. No morphological abnormalities were observed zebrafish exposed to 1.

Language: Английский

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The stability of MOFs in aqueous solutions—research progress and prospects

Green Chemical Engineering, Journal Year: 2023, Volume and Issue: 5(2), P. 187 - 204

Published: Aug. 1, 2023

Metal-organic frameworks (MOFs) are favored in the fields of adsorption, separation, catalysis, electrochemistry, and magnetism due to their advantages large specific surface area, high porosity, controllable pore size adjustment, dispersion metal active sites. The application MOFs involves multiple fields, which requires that have good water stability, as gaseous liquid inevitably exist industrial processes. In this paper, research status stability aqueous solutions reviewed recent years, including design synthesis, influencing factors, applications stability.

Language: Английский

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Current Challenges and Opportunities of Photodynamic Therapy against Cancer

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 330 - 330

Published: Jan. 18, 2023

BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are generated that ultimately induce cell death and disruption the tumor area. Moreover, PDT can result in damage to vasculature release and/or exposure damage-associated molecular patterns (DAMPs) may initiate antitumor immune response. However, there currently several challenges limit its widespread application certain indications clinic. METHODS: A literature study was conducted comprehensively discuss these identify opportunities improvement. RESULTS: The most notable improve them have been identified discussed. CONCLUSIONS: recent efforts current promising, notably those focus on enhancing responses initiated by treatment. improvements has potential enhance efficacy thereby broadening

Language: Английский

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A review of metal–organic framework (MOF) materials as an effective photocatalyst for degradation of organic pollutants

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(23), P. 6318 - 6348

Published: Jan. 1, 2023

An overview of MOFs and their composite materials for better photocatalytic performance towards organic pollutants.

Language: Английский

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Synergistic efficacy unleashed: Co/Ni-based catalysts as a versatile powerhouse for photocatalytic degradation of ornidazole

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 568, P. 122115 - 122115

Published: May 3, 2024

Language: Английский

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A magnetically separable clinoptilolite supported CdS-PbS photocatalyst: Characterization and photocatalytic activity toward cefotaxime

Applied Surface Science, Journal Year: 2022, Volume and Issue: 614, P. 156252 - 156252

Published: Dec. 27, 2022

Language: Английский

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Effect of Metal Atom in Zeolitic Imidazolate Frameworks (ZIF-8 & 67) for Removal of Dyes and Antibiotics from Wastewater: A Review

Catalysts, Journal Year: 2023, Volume and Issue: 13(1), P. 155 - 155

Published: Jan. 9, 2023

The use of antibiotics and dyes has resulted in severe water pollution health risks; therefore, it is urgent to remove them from sources. Among the most common methods for removing harmful contaminants, adsorption photodegradation are economical, simple, reusable. Due their high porosity, adjustability, crystal structure, metal-organic frameworks (MOFs) one effective adsorbents photocatalysts. A typical MOF material zeolitic imidazolate framework-8/67 (ZIF-8 ZIF-67), comprising essentially metal atoms Zn 2-methylimidazole (2-MIM). ZIF-8 ZIF-67 have unique properties that make efficient treatment due capacities being good hosts photocatalytic materials. In this article, a review study design synthesis composites presented. An introduction current research on role compounds as photocatalysts wastewater removal provided. study, we aim supply mechanistic perspective ZIF-8/67 purification present novel visions development extremely ZIF-8/67-based To unlock full potential dye antibiotic recycling, difficulties will be discussed detail.

Language: Английский

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Synthesis, Characterization, Antimicrobial, Density Functional Theory, and Molecular Docking Studies of Novel Mn(II), Fe(III), and Cr(III) Complexes Incorporating 4-(2-Hydroxyphenyl azo)-1-naphthol (Az)

ACS Omega, Journal Year: 2023, Volume and Issue: 8(29), P. 25877 - 25891

Published: July 14, 2023

This work synthesized three new CrAz2, MnAz2, and FeAz2 complexes investigated them using IR, mass, UV spectroscopy, elemental analysis, conductivity magnetic tests, thermogravimetric analysis. The azo-ligand, 4-(2-hydroxyphenylAzo)-1-naphthol (Az), couples with metal ions via its nitrogen (in -N=N- bonds) oxygen hydroxyl group) atoms, according to the IR spectra of these complexes. Through thermal examination (TG/TGA), number location water in were also determined. Density functional theory (DFT) is applied ameliorate structures ligand (Az) analyze quantum chemical characteristics antifungal antibacterial activity opposed several hazardous bacteria fungi was vitro. Metal discovered have a higher inhibitory impact on some organisms than free ligand. MnAz2 complex exhibited best among studied materials, whereas CrAz2 had lowest. compounds' binding affinity E. coli (PDB ID: 1hnj) structure predicted molecular docking. Binding energies calculated by analyzing protein-substrate interactions. These encouraging findings imply that chemicals may physiological effects be valuable for variety medical uses future.

Language: Английский

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Design, Synthesis, Spectroscopic Inspection, DFT and Molecular Docking Study of Metal Chelates Incorporating Azo Dye Ligand for Biological Evaluation

Materials, Journal Year: 2023, Volume and Issue: 16(3), P. 897 - 897

Published: Jan. 17, 2023

A new heterocyclic azo dye ligand (L) was synthesized by the combination of 4-amino antipyrine with 4-aminophenol. The Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) complexes were in excellent yields. metal chelate structures elucidated using elemental analyses, FT-IR, 1H-NMR, mass, magnetic moment, diffused reflectance spectral thermal analysis (TG-DTG), molar conductivity measurement. According to FT-IR study, exhibited neutral tri-dentate behavior, binding ions N, carbonyl O, protonated phenolic OH. 1H-NMR study Zn(II) complex supported coordination zo without proton displacement Diffused moment studies revealed octahedral geometry complexes, as well their good electrolytic nature, excepting which nonelectrolytes, deduced from study. theoretical calculations optimized HOMO-LUMO energies, geometrical parameters, electronic spectra, natural atomic charges, 3D-plots MEP, vibrational wavenumbers computed LANL2DZ 6-311G (d, p) basis sets density functional theory (DFT) approach B3LYP DFT TD-DFT methods. have been assayed for antimicrobial activity compared standard drugs. Most manifested against various microbial strains. molecular docking investigation also performed, acquire more information about mode energy its Escherichia coli receptor docking. Altogether, newly created showed positive antibacterial effects are worth future

Language: Английский

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Porous materials as effective chemiresistive gas sensors

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2530 - 2577

Published: Jan. 1, 2024

This review emphasizes the crucial role of chemiresistive gas sensors (CGS) in detection. It underscores porous materials as alternatives, showcasing their exceptional attributes. The explores CGS-based real-life applications.

Language: Английский

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