Primary components of MCT ketogenic diet are detrimental to bone loss associated with accelerated aging and age-related neurotoxicity in mice DOI
Shreshta Jain, Divya Vohora

Bone, Journal Year: 2024, Volume and Issue: unknown, P. 117383 - 117383

Published: Dec. 1, 2024

Language: Английский

γ-Glutamylcysteine ameliorates blood-brain barrier permeability and neutrophil extracellular traps formation after ischemic stroke by modulating Wnt/β-catenin signalling in mice DOI

Xinya Gu,

Mengqi Dong, Shengnan Xia

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 969, P. 176409 - 176409

Published: Feb. 15, 2024

Language: Английский

Citations

3
Ginsenoside Rg2 Promotes the Proliferation and Stemness Maintenance of Porcine Mesenchymal Stem Cells through Autophagy Induction DOI Creative Commons

Lina Che,

Caixia Zhu,

Lei Huang

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(5), P. 1075 - 1075

Published: March 2, 2023

Mesenchymal stem cells (MSCs) can be used as a cell source for cultivated meat production due to their adipose differentiation potential, but MSCs lose stemness and undergo replicative senescence during expansion in vitro. Autophagy is an important mechanism senescent remove toxic substances. However, the role of autophagy controversial. Here, we evaluated changes porcine (pMSCs) long-term culture vitro identified natural phytochemical, ginsenoside Rg2, that could stimulate pMSC proliferation. First, some typical characteristics were observed aged pMSCs, including decreased EdU-positive cells, increased senescence-associated beta-galactosidase activity, declined stemness-associated marker OCT4 expression, enhanced P53 expression. Importantly, autophagic flux was impaired suggesting deficient substrate clearance pMSCs. Rg2 found promote proliferation pMSCs using MTT assay EdU staining. In addition, inhibited D-galactose-induced oxidative stress activity via AMPK signaling pathway. Furthermore, with promoted proliferation, senescence, maintained These results provide potential strategy MSC

Language: Английский

Citations

8
γ-Glutamylcysteine rescues mice from TNBS-driven inflammatory bowel disease through regulating macrophages polarization DOI
Jinyi Zhou, Xintong Yan, Xiaowen Bi

et al.

Inflammation Research, Journal Year: 2023, Volume and Issue: 72(3), P. 603 - 621

Published: Jan. 24, 2023

Language: Английский

Citations

6
Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1/CDKN2A/REDD1/FoXO1/FasL signaling pathway in D‐galactose‐induced aging mice DOI Creative Commons
Yang Liu, Wen Guo, Si‐Lu Hong

et al.

The FASEB Journal, Journal Year: 2023, Volume and Issue: 37(10)

Published: Sept. 28, 2023

Brain aging is the most important risk factor for neurodegenerative disorders, and abnormal apoptosis linked to neuronal dysfunction. Specifically, studies have found that exercise effectively inhibits hippocampal apoptosis, while molecular mechanism remains unclear. In present study, we investigated impact of aerobic on in mice potential involvement DAPK1 its downstream pathways based recent data may be associated with death diseases. Senescent were subjected 8 weeks Aerobic training. Following behavioral testing, samples examined histologically biochemically detect pathological changes, mRNA protein levels. We intervention improved spatial memory alleviated brain. Notably, down-regulated expression inhibited Fas receptor transactivation mitochondrial apoptotic pathway hippocampus. These results shed new light protective effect regular against brain though modulating pathway.

Language: Английский

Citations

6
Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening DOI
Shanshan Hu,

Tong-yao Wang,

Lu Ni

et al.

Current Medical Science, Journal Year: 2024, Volume and Issue: 44(4), P. 748 - 758

Published: June 20, 2024

Language: Английский

Citations

2
Development of a brain-targeted nano drug delivery system to enhance the treatment of neurodegenerative effects of resveratrol DOI
Yang Yu, Shutong Li, Liang Kong

et al.

Journal of Liposome Research, Journal Year: 2023, Volume and Issue: 34(3), P. 435 - 451

Published: Nov. 30, 2023

As the aging population continues to increase, aging-related inflammation, oxidative stress, and neurodegenerative diseases have become serious global health threats. Resveratrol, a star molecule in natural polyphenols, has been widely reported physiological activities such as anti-aging, anti-inflammatory, antioxidant, neuroprotection. However, its poor water solubility, rapid metabolism, low bioavailability targeting ability, which limits application. Accordingly, brain-targeted resveratrol liposome (ANG-RES-LIP) was developed solve these issues. Experimental results showed that ANG-RES-LIP uniform size distribution, good biocompatibility, drug encapsulation rate of over 90%. Furthermore,

Language: Английский

Citations

3
γ‐Glutamylcysteine Ameliorates LPS‐Induced Inflammatory Responses in BV2 Cells via Activating Autophagy DOI Creative Commons
Shuai Lü, Min Tian, Guofeng Wu

et al.

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

In neurodegenerative diseases, the activation of microglia and ensuing neuroinflammation are pivotal in regulating disease progression. Attenuating inflammation induced by microglial cells is considered a key strategy for slowing progression diseases. γ‐glutamylcysteine (γ‐GC) has exhibited significant antioxidative anti‐inflammatory effects; nevertheless, its potential role modulating neuroinflammatory responses remains incompletely explored. The current investigation aimed to establish model stimulating BV2 with lipopolysaccharide (LPS) explore protective effect γ‐GC on cells. results demonstrated that significantly attenuated LPS‐induced oxidative damage cells, reduced levels tumor necrosis factor‐α (TNF‐α) interleukin‐1β (IL‐1β), inhibited cytoplasmic translocation high‐mobility group box 1 protein (HMGB1), effectively mitigated inflammatory response We further investigated regulatory mechanism found enhances autophagy resulting marked reduction mammalian target rapamycin (mTOR) phosphorylation an increase AMP‐activated kinase (AMPK) levels. use inhibitors 3‐methyladenine (3‐MA) AMPK corroborates proposition promotes while suppressing through AMPK‐mTOR pathway. findings indicate exerts substantial inhibitory impact neuroinflammation, making it promising candidate development therapeutic strategies against disorders related conditions.

Language: Английский

Citations

0
Extraction, purification, structural identification, and anti-senescent activity of novel pearl peptides on human dermal fibroblasts DOI
Xian‐Guo Zou,

Mengxiao Zhao,

Jianjian Fei

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 198, P. 115357 - 115357

Published: Nov. 19, 2024

Language: Английский

Citations

0
γ‐Glutamylcysteine Inhibits VSMC‐Derived Foam Cell Formation via Upregulating Thioredoxin‐1 Expression DOI Creative Commons
Jianzhen Lei, Jinyi Zhou, Fen Zheng

et al.

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

The formation and accumulation of foam cells within the arterial wall is main early event atherosclerosis. Vascular smooth muscle (VSMCs) are most abundant in human atherosclerotic lesions suggested to contribute atheroma cells. γ ‐glutamylcysteine ( ‐GC), as an immediate precursor glutathione, exhibits anti‐inflammatory antioxidant effects. However, effects ‐GC on plaques not yet clarified. Here, we display against ox‐LDL‐induced foamy VSMCs. Our results showed that apparently reduced total intracellular cholesterol content mouse rat oil red O fluorescent BODIPY staining indicated inhibited cell. Mechanistically, expression macrophage scavenger receptor 1 (Msr1) VSMCs attenuate uptake by Further RNA‐seq analysis, immunofluorescence well immunoblotting measurements thioredoxin‐1 (Txn1) was important for reduce Msr1 lipid Overall, our research increases Txn1 expression, which causes A reduction inhibition ox‐LDL‐stimulated study revealed has potential prevention

Language: Английский

Citations

0
Primary components of MCT ketogenic diet are detrimental to bone loss associated with accelerated aging and age-related neurotoxicity in mice DOI
Shreshta Jain, Divya Vohora

Bone, Journal Year: 2024, Volume and Issue: unknown, P. 117383 - 117383

Published: Dec. 1, 2024

Language: Английский

Citations

0