The Amorphous Solid Dispersion of Chrysin in Plasdone® S630 Demonstrates Improved Oral Bioavailability and Antihyperlipidemic Performance in Rats

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2378 - 2378

Published: Sept. 24, 2023

Chrysin is a flavonoid with various biological activities. However, its low water solubility and strong metabolism render oral bioavailability rather poor. This study aimed to develop stable solid dispersion formulation of chrysin improve the dissolution chrysin, so as increase antihyperlipidemic A was prepared using solvent evaporation method, Plasdone® S630 hydrophilic carrier. The formulations were characterized via X-ray diffraction, in vitro studies, stability studies. An in-situ perfusion model used evaluate absorption rates. Plasma pharmacokinetics performance after administration investigated rats. It found that drug–polymer mass ratio 1:6 can form optimized formulation. diffraction results showed an amorphous state this cumulative release percentage at pH 1.2 6.8 elevated above 90% within 24 h, indicating could enhance rates chrysin. Stability studies presented acceptable long-term storage stability, but it susceptible high temperature humidity. higher model. Pharmacokinetic revealed Cmax AUC intragastric appreciably than those resulting from suspension. 41 times Pharmacological suggested more powerful raw material improving biochemical indicators hyperlipidemic reveals potential use novel reduce currently required dose.

Language: Английский

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Anti-breast cancer activity of the essential oil from grapefruit mint (Mentha suaveolens × piperita)

Fitoterapia, Journal Year: 2024, Volume and Issue: 174, P. 105875 - 105875

Published: Feb. 28, 2024

Language: Английский

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Nutritional Modulation of Host Defense Peptide Synthesis: A Novel Host-Directed Antimicrobial Therapeutic Strategy?

Advances in Nutrition, Journal Year: 2024, Volume and Issue: 15(9), P. 100277 - 100277

Published: July 23, 2024

The escalating threat of antimicrobial resistance underscores the imperative for innovative therapeutic strategies. Host defense peptides (HDPs), integral components innate immunity, exhibit profound and immunomodulatory properties. Various dietary compounds, such as short-chain fatty acids, vitamins, minerals, sugars, amino phytochemicals, bile probiotics, prebiotics have been identified to enhance synthesis endogenous HDPs without provoking inflammatory response or compromising barrier integrity. Additionally, different classes these compounds synergize in augmenting HDP disease resistance. Moreover, supplementation several HDP-inducing their combinations demonstrated robust protection rodents, rabbits, pigs, cattle, chickens from experimental infections. However, efficacy inducing varies considerably among distinct compounds. regulation genes occurs a gene-specific, cell type–specific, species-specific manner. In this comprehensive review, we systematically summarized modulation mechanism action attributed each major class including synergistic combinations, across spectrum animal species humans. We argue that ability immunity function triggering inflammation microbial positions nutritional promising host-directed approach mitigating infectious diseases These particularly harbor substantial clinical potential further exploration therapies both human other animals.

Language: Английский

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Hypoglycemic Effect of Rambutan (Nephelium lappaceum L.) Peel Polyphenols on Type 2 Diabetes Mice by Modulating Gut Microbiota and Metabolites

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Type 2 diabetes mellitus (T2DM) is a metabolic disease with major global public health effect. Rambutan peel polyphenols (RPPs) have been reported to exert hypoglycemic activity. However, few studies explored from the viewpoint of gut microbiota and its metabolites.

Language: Английский

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Research advances in citrus polyphenols: green extraction technologies, gut homeostasis regulation, and nano-targeted delivery system application

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(31), P. 11493 - 11509

Published: Aug. 8, 2023

AbstractCitrus polyphenols can modulate gut microbiota and such bi-directional interaction that yield metabolites as short-chain fatty acids (SCFAs) to aid in homeostasis. Such provides citrus with powerful prebiotic potential, contributing guts' health status metabolic regulation. Citrus encompass unique polymethoxy flavonoids imparting non-polar nature improve their bioactivities ability penetrate the blood-brain barrier. Green extraction technology targeting recovery of these has received increasing attention due its advantages high yield, short time, low solvent consumption, environmental friendliness. However, bioavailability limits applications from by-products. Meanwhile, nano-encapsulation may serve a promising approach polyphenols' bioavailability. As multiple hydroxyl groups, they are potential interact bio-macromolecules proteins polysaccharides nano-encapsulated systems This multifaceted review research basis for green efficient techniques polyphenols, well integrated mechanisms anti-inflammation, alleviating syndrome, regulating homeostasis, which is more capitalized upon using nano-delivery discussed maximize food applications.Keywords: polyphenolsgreen extractionbioactivitybioavailabilitynano-delivery systemsgut homeostasis Disclosure statementNo conflict interest was reported by authors.Additional informationFundingThe work supported National Natural Science Foundation China (31601476), Zhejiang Provincial (LY21C200005), Youth Innovation Program Chinese Academy Agricultural Sciences (Grant Number Y2023QC34), Ningbo University "Student Research (2022SRIP3610)".

Language: Английский

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