Potential Effect of Curcumin in Lowering Blood Glucose Level in Streptozotocin-Induced Diabetic Rats

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 3305 - 3313

Published: Sept. 1, 2024

The prevalence of diabetes mellitus has significantly increased, with 537 million individuals living in 2021. Curcumin, a natural compound present turmeric, anti-inflammatory and antioxidant properties that aid controlling diabetes. Curcumin can lower blood glucose levels, increase pancreatic cell function, reduce insulin resistance. pathophysiology involves oxidative stress endoplasmic reticulum stress, which lead to death. This study aimed evaluate the antidiabetic activity curcumin rats by administering it for month evaluating tissue histology.

Language: Английский

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Impact of temperature on the binding interaction between dsDNA and curcumin: An electrochemical study

Bioelectrochemistry, Journal Year: 2023, Volume and Issue: 156, P. 108621 - 108621

Published: Nov. 27, 2023

Language: Английский

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The Effects of Plant-Derived Phytochemical Compounds and Phytochemical-Rich Diets on Females with Polycystic Ovarian Syndrome: A Scoping Review of Clinical Trials

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(15), P. 6534 - 6534

Published: Aug. 6, 2023

Polycystic ovarian syndrome (PCOS) is an endocrine condition that impacts nutritional status, metabolic, and hormonal function in females of reproductive age. This associated with increased androgen production (hyperandrogenism) decreased insulin sensitivity, which often leads to resistance hyperinsulinemia. increase strongly a high incidence obesity, type-2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), certain types gonad-related cancers among who suffer from this condition. As research continues grow, it has been demonstrated PCOS complex condition, some its characteristics vary the have disorder. However, suggested oxidative stress low-grade chronic inflammation could play important role development PCOS. Current evidence suggest phytochemicals potentially help weight-loss by reducing inflammation, as well aid metabolic regulation due their antioxidant properties. Some bioactive compounds found plants shown positive effects attenuation include flavonoids, polyphenols, phytoestrogen, polyunsaturated fatty acids (PUFAs). Thus, review current literature published on was conducted PubMed, Google Scholar, Academy Nutrition Dietetics databases for articles between 2013 2023 study duration 1 3 months adequate sample sizes. The main purpose investigate phytochemical phytochemical-rich diets comparing results several randomized clinical trials.

Language: Английский

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Biocompatible Anisole-Nonlinear PEG Core–Shell Nanogels for High Loading Capacity, Excellent Stability, and Controlled Release of Curcumin

Gels, Journal Year: 2023, Volume and Issue: 9(9), P. 762 - 762

Published: Sept. 18, 2023

Curcumin, a nontoxic and cheap natural medicine, has high therapeutic efficacy for many diseases, including diabetes cancers. Unfortunately, its exceedingly low water-solubility rapid degradation in the body severely limit bioavailability. In this work, we prepare series of biocompatible poly(vinyl anisole)@nonlinear poly(ethylene glycol) (PVAS@PEG) core–shell nanogels with different PEG gel shell thickness to provide water solubility, good stability, controllable sustained release curcumin. The PVAS nanogel core is designed attract store curcumin molecules drug loading capacity hydrophilic nonlinear offer dispersibility thermo-responsive release. prepared are monodispersed spherical shape clear morphology. size can be easily controlled by changing precursor feeding ratios. optimized PVAS@PEG display 38.0 wt%. stabilize from at pH = 7.4 it response heat within physiological temperature range. enter cells effectively exhibit negligible cytotoxicity both B16F10 HL-7702 concentration up 2.3 mg/mL. Such have great potential used efficient delivery.

Language: Английский

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Investigation on the lipid‐lowering effect and mechanism by combining turmeric with hawthorn in C57BL/6 obese mice

Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(7), P. 4493 - 4504

Published: May 28, 2024

Study on the hypolipidemic effect of turmeric combined with hawthorn C57BL/6 obese mice and its possible mechanism. C57 were fed 60% high-fat diet for 8 weeks to establish an obesity model, 4 slaughtered verify whether modeling was successful. The successful divided into model group (HFD), positive (high fat feed [HFD] + simvastatin [SIM]), (HFD TUR), HAW), para-medicine para-drug [DOU]) by gavage intervention. Different intervention groups had certain lipid-lowering effects, showed significant differences (p < 0.05, p 0.01, 0.001) in reducing serum total cholesterol, triglycerides, low-density lipoprotein glutamic acid transaminase (ALT), (AST), increasing high-density cholesterol. In group, protein expression peroxisome proliferator-activated receptor γ, fatty synthase, platelet-reactive 36, CCAAT/enhancer binding α significantly downregulated, carnitine palmitoyl transferase1 0.001), thus suggesting that are superior alone enhancing lipid metabolism-related mechanisms. Combined effects improve metabolism mice, protect liver, liver-related genes. This study can lay theoretical basis future association medicinal food products development related weight loss products.

Language: Английский

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Identification of natural curcumins as potential dual inhibitors of PTP1B and α-glucosidase through experimental and computational study

Kuwait Journal of Science, Journal Year: 2024, Volume and Issue: unknown, P. 100312 - 100312

Published: Sept. 1, 2024

Language: Английский

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Regulation Mechanism and Potential Value of Active Substances in Spices in Alcohol–Liver–Intestine Axis Health

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3728 - 3728

Published: March 27, 2024

Excessive alcohol intake will aggravate the health risk between liver and intestine affect multi-directional information exchange of metabolites host cells microbial communities. Because side effects clinical drugs, people tend to explore intervention value natural drugs on diseases. As a flavor substance, spices have been proven medicinal value, but they are still rare in treating hepatointestinal diseases caused by alcohol. This paper summarized metabolic transformation potential various perfume active substances improving It is also found that bioactive can exert antioxidant activity environment reduce oxidative stress These interfere with fatty acid synthesis, promote sugar lipid metabolism, injury steatosis. They effectively regulate balance intestinal flora, production SCFAs, restore microenvironment.

Language: Английский

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The Role of mTOR in Doxorubicin-Altered Cardiac Metabolism: A Promising Therapeutic Target of Natural Compounds

Cardiovascular Toxicology, Journal Year: 2023, Volume and Issue: 24(2), P. 146 - 157

Published: Dec. 18, 2023

Language: Английский

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Curcumins from <em>Curcuma longa </em>Potential Inhibit PTP1B and α-Glucosidase: Experimental and Computational Study

Published: April 25, 2023

Curcuma longa is only a rich source of curcumin (1) and its major analogues demethoxycurcumin (2) bisdemethoxycurcumin (3) among the species. The content ratio these three curcumins in turmeric depended on varieties growing environment. Recently, has been reported as potential inhibitor hepatic enzymatic protein tyrosine phosphatase 1B (PTP1B) related disorders such hypertriglyceridemia, hyperlipidemia liver steatosis. Thus, we further purified (1–3) from C. investigated their inhibitory effects against PTP1B α-glucosidase enzymes. As result, exhibited inhibition with IC50 values 37.8 ± 1.4, 45.3 0.7, 72.6 1.1 μM, respectively, similar manner (IC50 78.2 0.2, 82.4 0.6, 90.6 1.0 respectively). These results reveal key role methoxylation variation activity for curcumins. In addition, density functional theory (DFT) was used accompanying molecular docking (MD) to analyze ligand stability interaction glucoside hydrolase proteins. Assay-based MD data obtained are highly correlation suggesting that deterioration enzyme caused by distortion structural conformation may be arrangement amino acids structure. This first time have examined vitro silico well.

Language: Английский

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Biocompatible Anisole-Nonlinear PEG core-shell Nanogels for High Loading Capacity, Excellent Stability, and Controlled Release of Curcumin

Published: Aug. 30, 2023

Curcumin, a nontoxic and cheap natural medicine, has high therapeutic efficacy for many diseases including diabetes cancers. Unfortunately, its exceedingly low water-solubility rapid degradation in the body severely limit bioavailability. In this work, we prepare series of biocompatible poly(vinyl anisole)@nonlinear poly(ethylene glycol) (PVAS@PEG) core-shell nanogels with different PEG gel shell thickness to provide water solubility, good stability, controllable sustained release curcumin. The PVAS nanogel core is designed attract store curcumin molecules drug loading capacity hydrophilic nonlinear offer dispersibility thermo-responsive release. obtained are monodispersed spherical shape clear morphology. size can be easily controlled by changing precursor feeding ratios. optimized PVAS@PEG display 38.0 wt%. stabilize from at pH =7.4 response heat physiologically important temperature range. enter cells effectively exhibit negligible cytotoxicity both B16F10 HL-7702 concentration up 2.3 mg/mL. Such have great potential used delicate delivery.

Language: Английский

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