Protective Effect of Anthocyanin on Testicular Damage and Oxidative Stress Induced by Experimental Varicocele in Adult Rats: A Histological and Biochemical Study DOI Creative Commons

Ghazal Rahmanifar,

Arash Khaki,

Afshin Teymoori

et al.

Crescent Journal of Medical and Biological Sciences, Journal Year: 2023, Volume and Issue: 11(3), P. 147 - 153

Published: Sept. 6, 2023

Objectives: This study aimed to investigate the potential protective impact of anthocyanin against tissue damage and oxidative stress provoked by varicocele within testes adult rats. Materials Methods: A total 32 male rats were divided into four groups as follows: a control group undergoing sham procedure, without intervention (V), treated with (VA), receiving treatment alone. Following 56-day period, indicators gauged in blood plasma, while histological modifications evaluated utilizing hematoxylin eosin staining technique. Results: In anthocyanin, we observed noteworthy enhancements Johnsen score, epithelium thickness, seminiferous tubule diameter compared untreated group. Treatment exhibited substantial elevations testosterone levels antioxidant enzyme levels. Furthermore, there was reduction malondialdehyde (MDA), an established marker damage, decline groups. Conclusions: The outcomes underscore safeguarding influence testicular stemming from induction, suggesting its beneficial role countering impairment.

Language: Английский

Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis DOI Creative Commons
Muhammad Zahoor Khan, Adnan Khan, Wenting Chen

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 258 - 258

Published: Feb. 20, 2024

Heat stress represents a pervasive global concern with far-reaching implications for the reproductive efficiency of both animal and human populations. An extensive body published research on heat effects utilizes controlled experimental environments to expose cells tissues its disruptive influence physiological aspects phenotypic traits, encompassing parameters such as sperm quality, motility, viability, overall competence. Beyond these immediate effects, has been linked embryo losses, compromised oocyte development, even infertility across diverse species. One primary mechanisms underlying adverse outcomes is elevation reactive oxygen species (ROS) levels precipitating oxidative apoptosis within mammalian cells. Oxidative are recognized pivotal biological factors through which exerts impact male female In concerted effort mitigate detrimental consequences stress, supplementation antioxidants, in natural synthetic forms, explored potential intervention strategy. Furthermore, possess inherent self-protective that come into play during episodes aiding their survival. This comprehensive review delves multifaceted traits elucidates intricate molecular underpinning cells, compromise normal function. Additionally, we provide succinct overview antioxidant interventions highlight genetic biomarkers capabilities, collectively offering promising avenues ameliorating negative by restraining stress.

Language: Английский

Citations

9
Molecular imprinting-based Ru@SiO2-embedded covalent organic frameworks composite for electrochemiluminescence detection of cyanidin-3-O-glucoside DOI
Chen Cui,

Yunfeng Fan,

Yaxuan Chen

et al.

Talanta, Journal Year: 2024, Volume and Issue: 274, P. 125997 - 125997

Published: April 2, 2024

Language: Английский

Citations

4
Paternal Cyanidin-3-O-Glucoside Diet Improved High-Fat, High-Fructose Diet-Induced Intergenerational Inheritance in Male Offspring's Susceptibility to High-Fat Diet-Induced Testicular and Sperm Damage DOI
Yuxi Li, Liwang Liu, Yulin Zhang

et al.

Reproductive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

0
Synergistic protective effects of 3,4-dihydroxyphenylglycol and hydroxytyrosol in male rats against induced heat stress-induced reproduction damage DOI

Milad Sadeghirad,

Ali Soleimanzadeh, Ali Shalizar Jalali

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 190, P. 114818 - 114818

Published: June 15, 2024

Language: Английский

Citations

3
Biogenesis of stress granules and their role in the regulation of stress-induced male reproduction disorders DOI Creative Commons
Jiaxin Li, Linyuan Shen, Kai Wang

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 13, 2025

Stress granules (SGs) are conserved messenger ribonucleoprotein (mRNP) that form through rapid coalescence in the cytoplasm of eukaryotic cells under stressful environments. These dynamic membrane-free organelles can respond to a variety both intracellular and extracellular stressors. Studies have shown stress conditions such as heat stress, arsenite exposure, hypoxic induce SGs formation. The formation helps mitigates effects environmental stimuli on cells, protects them from damage, promotes cell survival. This paper focuses biogenesis summarizes role regulating stress-induced male reproductive disorders, with aim exploring potential means mitigating reproduction disorders. Numerous studies demonstrated detrimental germ be effectively suppressed by timely disassembly SGs. Therefore, phosphorylation eIF2α assembly could offer promising therapeutic strategy alleviate impacts health.

Language: Английский

Citations

0
Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury DOI Creative Commons
Ya Jiang,

B. Liu,

Yi Dang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 16, 2024

Testicular torsion is a critical urologic condition for which testicular detorsion surgery considered irreplaceable as well the golden method of reversal. However, surgical treatment equivalent to blood reperfusion process, and no specific drugs are available treat injuries. Salidroside (SAL) one main effective substances in rhodiola, has been shown have antioxidant antiapoptosis activities. This study was designed determine whether SAL exerted protective effect on ischemia-reperfusion (I/R) injury. In this study, I/R injury model testes reoxygenation (OGD/R) were used verification, administered at doses 100 mg/kg 0.05 mmol/L, respectively. After experiments, tissue TM4 Sertoli cells collected histopathologic biochemical analyses. The results revealed that improves structure regulates oxidation–antioxidation system. To further understand molecular mechanisms treating injuries, transcriptomics metabonomics analyses integrated. show Nfr2/HO-1/GPX4/ferroptosis signaling pathway enriched significantly, indicating it may be regulatory Thereafter, transfection with Nrf2 plasmid–liposome reverse verify anti-testicular treatment. Thus, suggested can protect against injuries by regulating Nfr2/HO-1/GPX4 inhibit ferroptosis potential drug

Language: Английский

Citations

1
Protocatechuic acid attenuates intestinal inflammation through TLR4/p38 and NF-κB pathways in heat-stressed broilers DOI Creative Commons
Sai Wang,

Xin Wang,

Yu Gao

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(12), P. 104424 - 104424

Published: Oct. 13, 2024

Protocatechuic acid (PCA), a major active component found in Eucommia ulmoides Oliver, is involved regulating oxidative stress and inflammation. Heat poses significant threat to the poultry industry. In this study, we investigated protective effect of PCA on intestinal homeostasis under heat stress. Our results indicated that improved growth performance broilers during Furthermore, mitigated jejunal damage attenuated upregulation inflammatory mediators, including TNF-α, IL-6, IL-1β, triggered by Concurrently, it restored activity superoxide dismutase (SOD) total antioxidant capacity (T-AOC). maintained jejunum function increasing levels ZO-1, Claudin-1, Occludin. Mechanistically, inhibited activation TLR4/p38 MAPK NF-κB pathways, thereby imbalance responses caused

Language: Английский

Citations

0
Protective Effect of Anthocyanin on Testicular Damage and Oxidative Stress Induced by Experimental Varicocele in Adult Rats: A Histological and Biochemical Study DOI Creative Commons

Ghazal Rahmanifar,

Arash Khaki,

Afshin Teymoori

et al.

Crescent Journal of Medical and Biological Sciences, Journal Year: 2023, Volume and Issue: 11(3), P. 147 - 153

Published: Sept. 6, 2023

Objectives: This study aimed to investigate the potential protective impact of anthocyanin against tissue damage and oxidative stress provoked by varicocele within testes adult rats. Materials Methods: A total 32 male rats were divided into four groups as follows: a control group undergoing sham procedure, without intervention (V), treated with (VA), receiving treatment alone. Following 56-day period, indicators gauged in blood plasma, while histological modifications evaluated utilizing hematoxylin eosin staining technique. Results: In anthocyanin, we observed noteworthy enhancements Johnsen score, epithelium thickness, seminiferous tubule diameter compared untreated group. Treatment exhibited substantial elevations testosterone levels antioxidant enzyme levels. Furthermore, there was reduction malondialdehyde (MDA), an established marker damage, decline groups. Conclusions: The outcomes underscore safeguarding influence testicular stemming from induction, suggesting its beneficial role countering impairment.

Language: Английский

Citations

0