Peanut Shell Extract Improves Markers of Glucose Homeostasis in Diabetic Mice by Modulating Gut Dysbiosis and Suppressing Inflammatory Immune Response DOI Open Access

Matthew Bender,

Julianna Maria Santos,

Jannette M. Dufour

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4158 - 4158

Published: Nov. 30, 2024

There is strong evidence that the tripartite interaction between glucose homeostasis, gut microbiota, and host immune system plays a critical role in pathophysiology of type 2 diabetes mellitus (T2DM). We reported previously peanut shell extract (PSE) improves mitochondrial function db/db mice by suppressing oxidative stress inflammation liver, brain, white adipose tissue. This study evaluated impacts PSE supplementation on liver histology, intestinal microbiome composition, innate response diabetic mice. Fourteen were randomly assigned to group (DM, AIN-93G diet) (1% wt/wt for 5 weeks. Six C57BL/6J received diet weeks (control group). Parameters homeostasis included serum insulin, HOMA-IR, HOMA-B, analysis pancreatic tissues insulin glucagon. assessed colon using microarray. Gut composition cecal contents was analyzed 16S rRNA gene amplicon sequencing. improved (decreased concentration, HOMA-B) reduced hepatic lipidosis reversed DM-induced shifts relative abundance sequence variants Enterorhabdus, Staphylococcus, Anaerotruncus, Akkermansia. Relative DM mice, had suppressed expression levels Cd8α, Csf2, Irf23 increased Tyk2, Myd88, Gusb liver. demonstrates T2DM-associated disorders part due suppression inflammation.

Language: Английский

Luteolin: A promising multifunctional natural flavonoid for human diseases DOI Creative Commons
Mingtao Zhu, Yanping Sun, Yang Su

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3417 - 3443

Published: April 26, 2024

Abstract Natural products are closely associated with human health. Luteolin (LUT), a flavonoid polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It noteworthy that LUT exhibits variety of beneficial pharmacological properties holds significant potential for clinical applications, particularly antitumor, anti‐convulsion, diabetes control, anti‐inflammatory, neuroprotection, anti‐oxidation, anti‐cardiovascular, other aspects. The mechanism action has been partially elucidated, including the mediation NF‐κB, toll‐like receptor, MAPK, Wnt/β‐catenin, PI3K/Akt, AMPK/mTOR, Nrf‐2, among others. review aimed to comprehensively consolidate essential information on natural sources, effects, therapeutic preventive potential, as well mechanisms LUT. objective establish theoretical basis continued development application

Language: Английский

Citations

33
Autophagy and its therapeutic potential in diabetic nephropathy DOI Creative Commons

Yu-Peng Han,

Lijuan Liu,

Jia-Lin Yan

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 20, 2023

Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is most significant microvascular complication diabetes and poses a severe public health concern due to lack effective clinical treatments. Autophagy lysosomal process that degrades damaged proteins organelles preserve cellular homeostasis. Emerging studies have shown disorder in autophagy results accumulation diabetic cells promotes development DN. regulated by nutrient-sensing pathways including AMPK, mTOR, Sirt1, several intracellular stress signaling such as oxidative endoplasmic reticulum stress. An abnormal nutritional status excess stresses caused diabetes-related metabolic disorders disturb autophagic flux, dysfunction Here, we summarized role DN focusing on modulate therapeutic interferences

Language: Английский

Citations

31
Luteolin Protects Pancreatic β Cells against Apoptosis through Regulation of Autophagy and ROS Clearance DOI Creative Commons

Ming Han,

Yuting Lu,

Yunhua Tao

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 975 - 975

Published: July 7, 2023

Diabetes, which is mainly characterized by increased apoptosis and dysfunction of beta (β) cells, a metabolic disease caused impairment pancreatic islet function. Previous studies have demonstrated that death-associated protein kinase-related apoptosis-inducing kinase-2 (Drak2) involved in regulating β cell survival. Since natural products multiple targets often are multifunctional, making them promising compounds for the treatment diabetes, we identified Drak2 inhibitors from product library. Among products, luteolin, flavonoid, was found to be most effective compound. In vitro, luteolin effectively alleviated palmitate (PA)-induced cells PA-induced primary vivo, showed tendency lower blood glucose levels. It also STZ-induced disruption mice. This function partially relied on inhibition. Furthermore, relieve oxidative stress promote autophagy possibly improving slowing progression diabetes. conclusion, our findings show effect relieving diabetes offer potential therapeutic target protection cells. We reveal some underlying mechanisms luteolin's cytoprotective

Language: Английский

Citations

18
NF-ĸB axis in diabetic neuropathy, cardiomyopathy and nephropathy: A roadmap from molecular intervention to therapeutic strategies DOI Creative Commons

Aryan Rezaee,

Parham Rahmanian,

Amirreza Nemati

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29871 - e29871

Published: April 18, 2024

Diabetes mellitus (DM) is a metabolic illness defined by elevated blood glucose levels, mediating various tissue alterations, including the dysfunction of vital organs. can lead to many consequences that specifically affect brain, heart, and kidneys. These issues are known as neuropathy, cardiomyopathy, nephropathy, respectively. Inflammation acknowledged pivotal biological mechanism contributes development diabetes consequences. NF-κB modulates inflammation immune system at cellular level. Its abnormal regulation has been identified in several clinical situations, cancer, inflammatory bowel illnesses, cardiovascular diseases, Mellitus (DM). The purpose this review evaluate potential impact on complications associated with DM. Enhanced activity promotes inflammation, resulting harm compromised organ performance. Phytochemicals, which therapeutic molecules, potentially decline level, therefore alleviating progression problems correlated More importantly, be influenced factors, such TLR4 Highlighting these factors facilitate novel therapies future.

Language: Английский

Citations

6
Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy DOI Creative Commons

Fengzhao Liu,

Lijuan Zhao, Tao Wu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

As the quality of life improves, incidence diabetes mellitus and its microvascular complications (DMC) continues to increase, posing a threat people's health wellbeing. Given limitations existing treatment, there is an urgent need for novel approaches prevent treat DMC. Autophagy, pivotal mechanism governing metabolic regulation in organisms, facilitates removal dysfunctional proteins organelles, thereby sustaining cellular homeostasis energy generation. Anomalous states pancreatic β-cells, podocytes, Müller cells, cardiomyocytes, Schwann cells DMC are closely linked autophagic dysregulation. Natural products have property being multi-targeted can affect autophagy hence progression terms nutrient perception, oxidative stress, endoplasmic reticulum inflammation, apoptosis. This review consolidates recent advancements understanding pathogenesis via proposes perspectives on treating by either stimulating or inhibiting using natural products.

Language: Английский

Citations

5
Molecular Mechanisms and Therapeutic Perspectives of Luteolin on Diabetes and Its Complications DOI

Qingzhi Liang,

Xiaoqin Liu,

Xin Xu

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177691 - 177691

Published: April 1, 2025

Language: Английский

Citations

0
Luteolin alleviates diabetic cardiac injury related to inhibiting SHP2/STAT3 pathway DOI
Jie Pan,

Meinuo Chen,

Chunyan Jiang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 989, P. 177259 - 177259

Published: Jan. 8, 2025

Language: Английский

Citations

0
Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies DOI Creative Commons

Mahwish,

Muhammad Imran, Hammad Naeem

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

ABSTRACT Luteolin is widely distributed phytochemical, a flavonoid, in kingdom plantae. with potential antioxidant activity prevent ROS‐induced damages and reduce oxidative stress which mainly responsible pathogenesis of many diseases. Several chemo preventive activities therapeutic benefits are associated luteolin. prevents cancer via modulation numerous pathways, that is, by inactivating proteins; such as procaspase‐9, CDC2 cyclin B or upregulation caspase‐9 caspase‐3, cytochrome C, A, CDK2, APAF‐1, turn inducing cell cycle arrest well apoptosis. It also enhances phosphorylation p53 expression level p53‐targeted downstream gene. By Increasing BAX protein expression; decreasing VEGF Bcl‐2 it can initiate stimulate mitochondrial‐modulated functions to cause cellular death. levels p‐Akt, p‐EGFR, p‐Erk1/2, p‐STAT3. plays positive role against cardiovascular disorders improving cardiac function, the release inflammatory cytokines enzymes, prevention fibrosis hypertrophy; CTGF, TGFβ1, ANP, Nox2, Nox4 gene expressions. Meanwhile suppresses TGFβ1 JNK. helps fight diabetes inhibition alpha‐glucosidase ChE activity. catalase, superoxide dismutase, GS4. improve blood glucose, insulin, HOMA‐IR, HbA1c levels. This review an attempt elaborate molecular targets luteolin its modulating irregularities pathways overcome severe outcomes during diseases including cancer, disorders, diabetes, obesity, inflammation, Alzheimer's disease, Parkinson's hepatic renal brain injury, asthma. As has enormous benefits, could be candidate future drug development strategies.

Language: Английский

Citations

0
Interplay Between Polyphenols and Autophagy: Insights From an Aging Perspective DOI Creative Commons
Alejandro Ponce‐Mora, Nelson Bautista Salazar, Alicia Domenech‐Bendaña

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(3)

Published: March 19, 2025

The relationship between polyphenols and autophagy, particularly in the context of aging, presents a promising avenue for therapeutic interventions age-related diseases. A decline autophagy is associated with aging-related affections, an increasing number studies suggest that this enhancement linked to cellular resilience longevity. This review delves into multifaceted roles homeostasis potential modulate autophagic pathways. We revised most updated literature regarding modulatory effects on cardiovascular, liver, kidney diseases, highlighting their potential. highlight role as modulators combat thus contributing improving quality life aging populations. better understanding interplay will help pave way future research clinical applications field longevity medicine.

Language: Английский

Citations

0
Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients DOI
L.W. Yan,

M Jiang,

Xinsheng Fan

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 317, P. 116773 - 116773

Published: June 10, 2023

Language: Английский

Citations

9