Focus on podocytes: diabetic kidney disease and renal fibrosis — a global bibliometric analysis (2000–2024) DOI Creative Commons

Deok-Gyun An,

Jun Tan, Yiping Lu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 15, 2024

Background Diabetic kidney disease (DKD) is a common pathway to End-stage renal (ESRD). Podocytes are crucial due their dual barrier functions in diseases. Their role fibrosis and DKD regulatory mechanisms increasingly studied. However, bibliometric research this field has not been explored. Methods 1,250 publications from Jan. 1, 2000, Feb. 16, 2024, were retrieved the WoSCC database analyzed by Web of Science results analysis tool, VOSviewer, CiteSpace. Results Our scrutiny reveals that authors Liu Youhua, Fogo Agnes B, Zhao Yingyong have made substantial contributions domain. Notably, “Kidney International” highest volume area. Furthermore, our identifies ten co-citation clusters: DKD, IncRNA, reactive oxygen species, glomerulosclerosis, Poria cocos, glomerular diseases, fibroblasts, connective tissue growth factor, coagulation, Wnt. Recent accentuates keywords such as autophagy, TRPC6, ERS, epigenetics, NLRP3 inflammasome frequently occurring terms field. The prevailing hotspot include biomarker, exosomes. Conclusion Through utilization tools knowledge graph analysis, we undertaken comprehensive review intricate nexus between podocytes fibrosis. This study imparts valuable insights scholars regarding dynamic evolution association delineates prospective avenues pivotal realm.

Language: Английский

Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges. DOI Creative Commons
Great Iruoghene Edo, Alice Njolke Mafe, Patrick Othuke Akpoghelie

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

Citations

2
Targeting autophagy in diabetic cardiomyopathy: From molecular mechanisms to pharmacotherapy DOI Open Access
Jie Li, Yingying Xie, Shuwen Zheng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116790 - 116790

Published: May 22, 2024

Diabetic cardiomyopathy (DCM) is a cardiac microvascular complication caused by metabolic disorders. It characterized myocardial remodeling and dysfunction. The pathogenesis of DCM associated with abnormal cellular metabolism organelle accumulation. Autophagy thought to play key role in the diabetic heart, growing body research suggests that modulating autophagy may be potential therapeutic strategy for DCM. Here, we have summarized major signaling pathways involved regulation DCM, including Adenosine 5'-monophosphate-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), Forkhead box subfamily O proteins (FOXOs), Sirtuins (SIRTs), PTEN-inducible 1 (PINK1)/Parkin. Given significant further identified natural products chemical drugs as regulators treatment This review help better understand mechanism promote their clinical application.

Language: Английский

Citations

2
Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy DOI Creative Commons

Fengzhao Liu,

Zhenyu Yang, Jixin Li

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 20, 2024

Abstract Diabetic kidney disease (DKD), one of the most prevalent microvascular complications diabetes, arises from dysregulated glucose and lipid metabolism induced by hyperglycemia, resulting in deterioration renal cells such as podocytes tubular epithelial cells. Programmed cell death (PCD), comprising apoptosis, autophagy, ferroptosis, pyroptosis, necroptosis, represents a spectrum demise processes intricately governed genetic mechanisms vivo. Under physiological conditions, PCD facilitates turnover cellular populations serves protective mechanism to eliminate impaired or cells, thereby preserving tissue homeostasis amidst hyperglycemic stress. However, existing research predominantly elucidates individual modes death, neglecting intricate interplay mutual modulation observed among various forms PCD. In this comprehensive review, we delineate diverse regulatory governing elucidate crosstalk dynamics distinct pathways. Furthermore, review recent advancements understanding pathogenesis explore their implications DKD. Additionally, potential natural products derived primarily botanical sources therapeutic agents, highlighting multifaceted effects on modulating crosstalk, proposing novel strategies for DKD treatment.

Language: Английский

Citations

1
Mechanistic Insights and Therapeutic Potential of Astilbin and Apigenin in Diabetic cardiomyopathy DOI Creative Commons

Sachin Dhiman,

Sanchit Dhankhar, Anjali Garg

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39996 - e39996

Published: Nov. 1, 2024

Language: Английский

Citations

0
Focus on podocytes: diabetic kidney disease and renal fibrosis — a global bibliometric analysis (2000–2024) DOI Creative Commons

Deok-Gyun An,

Jun Tan, Yiping Lu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 15, 2024

Background Diabetic kidney disease (DKD) is a common pathway to End-stage renal (ESRD). Podocytes are crucial due their dual barrier functions in diseases. Their role fibrosis and DKD regulatory mechanisms increasingly studied. However, bibliometric research this field has not been explored. Methods 1,250 publications from Jan. 1, 2000, Feb. 16, 2024, were retrieved the WoSCC database analyzed by Web of Science results analysis tool, VOSviewer, CiteSpace. Results Our scrutiny reveals that authors Liu Youhua, Fogo Agnes B, Zhao Yingyong have made substantial contributions domain. Notably, “Kidney International” highest volume area. Furthermore, our identifies ten co-citation clusters: DKD, IncRNA, reactive oxygen species, glomerulosclerosis, Poria cocos, glomerular diseases, fibroblasts, connective tissue growth factor, coagulation, Wnt. Recent accentuates keywords such as autophagy, TRPC6, ERS, epigenetics, NLRP3 inflammasome frequently occurring terms field. The prevailing hotspot include biomarker, exosomes. Conclusion Through utilization tools knowledge graph analysis, we undertaken comprehensive review intricate nexus between podocytes fibrosis. This study imparts valuable insights scholars regarding dynamic evolution association delineates prospective avenues pivotal realm.

Language: Английский

Citations

0