Design and development of alteplase and borneol inclusion complex incorporated supramolecular hydrogel delivery enhanced the treatment and care of ischemic stroke

Particulate Science And Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: May 2, 2025

Language: Английский

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Emerging production techniques and potential health promoting properties of plant and animal protein-derived bioactive peptides

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 30

Published: Aug. 29, 2024

Bioactive peptides (BPs) are short amino acid sequences that known to exhibit physiological characteristics such as antioxidant, antimicrobial, antihypertensive and antidiabetic properties, suggesting they could be exploited functional foods in the nutraceutical industry. These BPs can derived from a variety of food sources, including milk, meat, marine, plant proteins. In past decade, various methods silico, vitro, vivo techniques have been explored unravel underlying mechanisms BPs. To forecast interactions between their targets, silico BIOPEP, molecular docking Quantitative Structure-Activity Relationship modeling employed. Additionally, vitro research has examined how affect enzyme activities, protein expressions, cell cultures. studies on contrary appraised impact animal models human subjects. Hence, light recent literature, this review examines multifaceted aspects production proteins potential bioactivities. We envisage concepts discussed will contribute better understanding BP production, which pave way for applications

Language: Английский

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Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactions by TBEC/Oxyma Couplings in an Environmentally Sensible Solvent

Organic Process Research & Development, Journal Year: 2023, Volume and Issue: 27(7), P. 1348 - 1364

Published: June 23, 2023

The finding that the widely used peptide coupling reagents DIC and Oxyma form toxic H-CN (McFarland, A. D. Org. Process Res. Dev. 2019, 23, 2099) has prompted studies aimed at minimization, attained, for example, by solvent engineering (Erny, M. 2020, 24, 1341) substituting with TBEC (Manne, S. R. 2022, 26, 2894). Here, an integrated study of TBEC/Oxyma as couplers is reported, focusing not only on performance in couplings but also its cost, hazards associated use, sustainability route synthesis, end life strategies, well potential impact impurities reagent synthesis. TBEC/Oxyma-mediated NBP/EtOAc (1:4) proceeded minimal racemization, free precipitation, radical side reactions irrespective quality. These results hold great promise broad adoption suitable green media a strategy sustainable synthesis from R&D lab to manufacturing plant.

Language: Английский

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Peptide spiders are emerging as novel therapeutic interventions for nucleic acid delivery

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(7), P. 104021 - 104021

Published: May 13, 2024

Language: Английский

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Sustainable Approaches in Solid-phase Peptide Synthesis (SPPS)

Royal Society of Chemistry eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 50 - 84

Published: Oct. 18, 2024

Solid-phase peptide synthesis (SPPS) is a ubiquitous methodology for making peptides from R&D to manufacturing plant, not least in the context of using and peptidometics as pharmaceuticals. Nevertheless, SPPS has long been plagued by its reliance on large amounts hazardous materials such dimethylformamide solvent trifluoroacetic acid cleavage reagent. Consequently, with methods producing sustainable manner being high demand, numerous reports covering various aspects greening have appeared recent years. In this chapter, an integrated overview state-of-the-art field presented, highlighting advances within entire workflow starting amino coupling cycle cleaving off polymer support. Greener assembly complex waste minimization tactics are also delineated, together discussion adoption practice, scale-up, procurement, costs intellectual property key considerations attaining truly SPPS. Finally, perspective future directions towards elevating versatile, platform provided.

Language: Английский

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Unveiling the Configurational Landscape of Carbamate: Paving the Way for Designing Functional Sequence-Defined Polymers

The Journal of Physical Chemistry A, Journal Year: 2023, Volume and Issue: 127(35), P. 7309 - 7322

Published: Aug. 25, 2023

Carbamate is an emerging class of a polymer backbone for constructing sequence-defined, abiotic polymers. It expected that new functional materials can be de novo designed by controlling the primary polycarbamate sequence. While amino acids have been actively studied as building blocks protein folding and peptide self-assembly, carbamates not widely investigated from this perspective. Here, we combined infrared (IR), vibrational circular dichroism (VCD), nuclear magnetic resonance (NMR) spectroscopy with density theory (DFT) calculations to understand conformation carbamate monomer units in nonpolar, aprotic environment (chloroform). Compared acid blocks, are more rigid, presumably due extended delocalization π-electrons on backbones. Cis configurations amide bond energetically stable carbamates, whereas peptides often assume trans at low energies. This study lays essential foundation future developments carbamate-based sequence-defined material design.

Language: Английский

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Synthetic electrochemistry for peptides

Current Opinion in Electrochemistry, Journal Year: 2024, Volume and Issue: 45, P. 101469 - 101469

Published: March 7, 2024

Language: Английский

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Greener Cleavage of Protected Peptide Fragments from Sieber Amide Resin

ChemistryOpen, Journal Year: 2022, Volume and Issue: 11(12)

Published: Dec. 1, 2022

Following the successful introduction of two benign solvents for cleaving protected acid peptide fragments from 2-chlorotrityl chloride (2-CTC) resin, there is a need to green cleavage process obtaining amide fragments. In this work, p-xylene and toluene are introduced as greener alternates dichloromethane (DCM) preparing Sieber resin. The N-dealkylation demanding chemical reaction, requiring that protocol be optimised ensure complete After 30 min reaction time, only 66 % final product was retrieved even with conventional solvent. Therefore, 120 considered sufficient fully cleave This work reaffirms fact greening strategies far detrimental, alternatives often outperforming their replaced counterparts.

Language: Английский

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Novel amino‐Li resin for water‐based solid‐phase peptide synthesis

Journal of Peptide Science, Journal Year: 2023, Volume and Issue: 29(12)

Published: June 15, 2023

We report the first application of a novel amino-Li resin to water-based solid-phase peptide synthesis (SPPS) applying Smoc-protecting group approach. demonstrated that it is suitable support for sustainable alternative classical SPPS The possesses good swelling properties in aqueous milieu, provides significant coupling sites, and may be applicable difficult sequences aggregation-prone peptides.

Language: Английский

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Microwave-Assisted Solid Phase Synthesis of Different Peptide Bonds: Recent Advancements

Current Microwave Chemistry, Journal Year: 2023, Volume and Issue: 10(2), P. 155 - 179

Published: Sept. 1, 2023

Abstract: Peptides are important as drugs and biologically active molecules. The synthesis of pep-tides has gathered considerable attention in recent years due to their various attractive properties. Conventional peptide is tedious requires hazardous reagents solvents. Micro-wave-assisted solid-phase several advantages compared with conventional batch synthesis. Herein, we have discussed microwave-assisted bond methods developed over the last five years. categorized into four groups - small, medium, large, cyclic based on length structural characteristics make it easier understand. This review article also discusses scope limitations

Language: Английский

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