Synthesis of 3,4-dihydroisoquinolin-1(2H)-one derivatives and their antioomycete activity against the phytopathogen Pythium recalcitrans DOI Creative Commons
Delong Wang,

Min Li,

Jing Li

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(16), P. 10523 - 10541

Published: Jan. 1, 2023

A collection of 3,4-dihydroisoquinolin-1(2 H )-one derivatives were synthesized by Castagnoli–Cushman reaction to screen antioomycete agents against Pythium recalcitrans .

Language: Английский

Design, synthesis, modeling studies and biological evaluation of pyrazole derivatives linked to oxime and nitrate moieties as nitric oxide donor selective COX-2 and aromatase inhibitors with dual anti-inflammatory and anti-neoplastic activities DOI

Wael A.A. Fadaly,

Yaseen A. M. M. Elshaier, Mohamed T. M. Nemr

et al.

Bioorganic Chemistry, Journal Year: 2023, Volume and Issue: 134, P. 106428 - 106428

Published: Feb. 19, 2023

Language: Английский

Citations

28
Recent Advances in Indole Synthesis and the Related Alkylation DOI
Jie Ma,

Rong Feng,

Zhi‐Bing Dong

et al.

Asian Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 12(6)

Published: May 2, 2023

Abstract The derivatives of indoles are very useful intermediates in pharmaceuticals and organic synthesis. efficient synthesis the indole blocks related functionalizations, especially alkylation hot topics recent years. This review will focus on following two aspects: i) new developments for which was catalyzed by transition metals, indoles, including one N 1 ‐position, C 2 as well 3 ‐position. 1. Introduction 2. Synthesis various metals 2.1. palladium catalysts 2.2. other metal 3. Alkylation 3.1. ‐alkylation 3.2. 3.3.

Language: Английский

Citations

25
Novel guanidine derivatives targeting leukemia as selective Src/Abl dual inhibitors: Design, synthesis and anti-proliferative activity DOI
Amr H. Moustafa, Asmaa M. AboulMagd,

Ali M. Ali

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 147, P. 107410 - 107410

Published: April 27, 2024

Language: Английский

Citations

15
Design, synthesis, antineoplastic activity of new pyrazolo[3,4-d]pyrimidine derivatives as dual CDK2/GSK3β kinase inhibitors; molecular docking study, and ADME prediction DOI
Mohamed T. M. Nemr, Ahmed Elshewy, Mohammed L. Ibrahim

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107566 - 107566

Published: June 15, 2024

Language: Английский

Citations

15
Insight Study For Repurposing Of Certain Anti‐Inflammatory Drugs Based On Aspirin and Salicylic Acid Scaffolds For The Treatment of Cancer as CDKs Inhibitors: Cheminformatics and Anticancer Studies DOI
Mohnad Abdalla, Ahmed E. Elmasry, Mohamed T. M. Nemr

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(15)

Published: April 1, 2025

Abstract The highly increased and global mortality due to cancer has created an urgent need discover promising targets for its treatment. Where drug repurposing was considered as attractive approach that can facilitate the lead generation optimization phases of discovery by existing agents target diseases other than their primary uses. Cheminformatics studies represented in molecular docking well dynamic simulation salicylic acid / aspirin analogues sulindac indomethacin anti‐inflammatory drugs were carried out be used cyclin‐dependent kinases (CDKs) namely CDK2, CDK6, CDK12 inhibitors. Sulindac displayed best binding ligand all receptors. CDKs inhibition effects three sulindac, anthranilic demonstrated good inhibitory activity against ranging from 0.48 1.78 µM. Likewise, cytotoxicity revealed potent anticancer 0.155 1.278 µM cell lines: HCT‐116, MCF‐7, HeLa cells. As a result, this technique saves lot time money order new agents.

Language: Английский

Citations

1
Design, synthesis and chemoinformatic studies of new thiazolopyrimidine derivatives as potent anticancer agents via phosphodiesterase-5 inhibition and apoptotic inducing activity DOI
Mohamed T. M. Nemr, Mohamed A. Mohamed Teleb, Asmaa M. AboulMagd

et al.

Journal of Molecular Structure, Journal Year: 2022, Volume and Issue: 1272, P. 134216 - 134216

Published: Sept. 26, 2022

Language: Английский

Citations

24
Catalytic asymmetric dearomative azo-Diels–Alder reaction of 2-vinlyindoles DOI
Yu‐Hang Miao,

Zheng‐Xu Zhang,

Xu-Yi Huang

et al.

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(4), P. 108830 - 108830

Published: July 27, 2023

Language: Английский

Citations

12
The literature of heterocyclic chemistry, part XXII, 2022 DOI
Галина А. Газиева, Yu. B. Evdokimenkova, N. O. Soboleva

et al.

Advances in heterocyclic chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Direct selenosulfonylation of unsaturated compounds: a review DOI Creative Commons

Tarik Hafdhi Abdtawfeeq,

Evan Abdulkareem Mahmood,

Seyedeh Bahareh Azimi

et al.

RSC Advances, Journal Year: 2022, Volume and Issue: 12(47), P. 30564 - 30576

Published: Jan. 1, 2022

In this review, we have discussed recent developments on the direct selenosulfonylation of unsaturated compounds which lead to formation two new carbon-sulfur and carbon-selenium bonds in a single operation.

Language: Английский

Citations

14
Synthesis of tetrahydrocarbazoles through a radical cation [4+2] cycloaddition reaction of 2-vinylindoles DOI Creative Commons
Elisa Brambilla, Elisa Moretti, Mirko Magni

et al.

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(22), P. 3281 - 3284

Published: Jan. 1, 2023

A redox umpolung strategy for the synthesis of complex tetrahydrocarbazoles is reported.

Language: Английский

Citations

7