Current Opinion in Biotechnology,
Journal Year:
2023,
Volume and Issue:
85, P. 103057 - 103057
Published: Dec. 28, 2023
Microbial
biomanufacturing
offers
a
promising,
environment-friendly
platform
for
next-generation
chemical
production.
However,
its
limited
industrial
implementation
is
attributed
to
the
slow
production
rates
of
target
compounds
and
time-intensive
engineering
high-yield
strains.
This
review
highlights
how
metabolomics
expedites
bioproduction
development,
as
demonstrated
through
case
studies
integration
into
microbial
strain
engineering,
culture
optimization,
model
construction.
The
Design-Build-Test-Learn
(DBTL)
cycle
serves
standard
workflow
engineering.
Process
including
optimization
conditions
scale-up,
crucial
In
silico
models
facilitate
development
strains
processes.
Metabolomics
powerful
driver
DBTL
framework,
process
Genes,
Journal Year:
2024,
Volume and Issue:
16(1), P. 16 - 16
Published: Dec. 26, 2024
Modern
sequencing
technologies
have
transformed
the
identification
of
medicinal
plant
species
and
varieties,
overcoming
limitations
traditional
morphological
chemical
approaches.
This
review
explores
key
DNA-based
techniques,
including
molecular
markers,
DNA
barcoding,
high-throughput
sequencing,
their
contributions
to
enhancing
accuracy
reliability
identification.
Additionally,
integration
multi-omics
approaches
is
examined
provide
a
comprehensive
understanding
identity.
The
literature
search
for
this
was
conducted
across
databases
such
as
Google
Scholar,
Web
Science,
PubMed,
using
keywords
related
taxonomy,
genomics,
biotechnology.
Inclusion
criteria
focused
on
peer-reviewed
studies
closely
methods
techniques
that
contribute
significantly
field.
highlights
while
offer
substantial
improvements,
challenges
high
costs,
technical
expertise,
lack
standardized
protocols
remain
barriers
widespread
adoption.
Potential
solutions,
AI-driven
data
analysis
portable
sequencers,
are
discussed.
provides
overview
transformative
impact,
future
perspectives
more
accurate
efficient
Current Opinion in Chemical Biology,
Journal Year:
2024,
Volume and Issue:
81, P. 102477 - 102477
Published: June 14, 2024
Food
colorants
are
frequently
added
to
processed
foods
since
color
is
an
important
tool
in
the
marketing
of
food
products,
influencing
consumer
perceptions,
preferences,
and
purchasing
behavior.
While
synthetic
dyes
currently
dominate
colorant
market,
concern
regarding
their
safety
sustainability
driving
a
demand
for
replacement
with
naturally
derived
alternatives.
However,
natural
costly
compared
counterparts
as
pigment
content
native
sources
usually
very
low
extraction
can
be
challenging.
Recent
advances
engineering
microbial
metabolism
have
sparked
interest
development
cell
factories
capable
producing
from
renewable
resources.
This
review
summarizes
major
developments
within
metabolic
production
nature-identical
by
fermentation.
Additionally,
it
highlights
common
applications,
formulations,
physicochemical
characteristics
prevalent
classes.
Lastly,
outlines
workflow
accelerating
optimization
or
derivatization
colorants.
Frontiers in Plant Science,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 8, 2023
Plants
produce
a
diverse
range
of
specialized
metabolites
that
play
pivotal
roles
in
mediating
environmental
interactions
and
stress
adaptation.
These
unique
chemical
compounds
also
hold
significant
agricultural,
medicinal,
industrial
values.
Despite
the
expanding
knowledge
their
functions
plant
interactions,
understanding
intricate
biosynthetic
pathways
these
natural
products
remains
challenging
due
to
gene
pathway
redundancy,
multifunctionality
proteins,
activity
enzymes
with
broad
substrate
specificity.
In
past
decade,
substantial
progress
genomics,
transcriptomics,
metabolomics,
proteomics
has
made
exploration
metabolism
more
feasible
than
ever
before.
Notably,
recent
advances
integrative
multi-omics
computational
approaches,
along
other
technologies,
are
accelerating
discovery
metabolism.
this
review,
we
present
summary
stress-related
metabolites.
Emphasis
is
placed
on
application
advanced
omics-based
approaches
techniques
studying
Additionally,
discuss
high-throughput
methods
for
functional
characterization.
great
promise
harnessing
potential
enhance
resilience
future.
Military Medical Research,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: May 27, 2024
Abstract
Aging
and
regeneration
represent
complex
biological
phenomena
that
have
long
captivated
the
scientific
community.
To
fully
comprehend
these
processes,
it
is
essential
to
investigate
molecular
dynamics
through
a
lens
encompasses
both
spatial
temporal
dimensions.
Conventional
omics
methodologies,
such
as
genomics
transcriptomics,
been
instrumental
in
identifying
critical
facets
of
aging
regeneration.
However,
methods
are
somewhat
limited,
constrained
by
their
resolution
lack
capacity
dynamically
tissue
alterations.
The
advent
emerging
spatiotemporal
multi-omics
approaches,
encompassing
proteomics,
metabolomics,
epigenomics,
furnishes
comprehensive
insights
into
intricate
dynamics.
These
sophisticated
techniques
facilitate
accurate
delineation
patterns
across
an
array
cells,
tissues,
organs,
thereby
offering
in-depth
understanding
fundamental
mechanisms
at
play.
This
review
meticulously
examines
significance
realms
research.
It
underscores
how
methodologies
augment
our
comprehension
dynamics,
cellular
interactions,
signaling
pathways.
Initially,
delineates
foundational
principles
underpinning
methods,
followed
evaluation
recent
applications
within
field.
ultimately
concludes
addressing
prevailing
challenges
projecting
future
advancements
Indubitably,
deciphering
complexities
inherent
regeneration,
thus
charting
course
toward
potential
therapeutic
innovations.
