Stem cells vesicles-loaded type I pro-photosensitizer for synergetic oxygen-independent phototheranostics and microenvironment regulation in infected diabetic wounds

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159239 - 159239

Published: Jan. 10, 2025

Language: Английский

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Structure characterization of a Bletilla striata homogeneous polysaccharide and its effects on reducing oxidative stress and promoting wound healing in diabetic rats

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141904 - 141904

Published: March 1, 2025

Language: Английский

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Environment‐Responsive Therapeutic Platforms for the Treatment of Implant Infection

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(26)

Published: May 15, 2023

Abstract The application of medical implants has greatly improved the survival rate and life quality patients. Nevertheless, in recent years, there are increasing cases implant dysfunction or failure because bacterial infections. Despite significant improvements biomedicine, still serious challenges treatment implant‐related With formation biofilms development resistance, these limitations lead to a low efficacy conventional antibiotics. To address challenges, it is urgent exploit innovative strategies for Based on ideas, environment‐responsive therapeutic platforms with high selectivity, drug minor dose‐limiting toxicity have attracted widespread attention. By using exogenous/endogenous stimuli, antibacterial activity therapeutics can be activated demand exhibit remarkable effects. Exogenous stimuli include photo, magnetism, microwave, ultrasound. Endogenous mainly pathological characteristics infections such as acidic pH, anomalous temperature, abnormal enzymatic activities. In this review, progress spatiotemporally controlled release/activation systematically summarized. Afterward, opportunities emerging highlighted. Finally, hoped that review will offer novel ideas techniques combat

Language: Английский

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Recent progress in nanozymes for the treatment of diabetic wounds

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(29), P. 6746 - 6761

Published: Jan. 1, 2023

The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.

Language: Английский

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Advances in image-guided drug delivery for antibacterial therapy

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 192, P. 114634 - 114634

Published: Nov. 28, 2022

Language: Английский

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A simple yet effective hydrogel dressing for advanced microenvironmental management of diabetic wounds with intrinsic regulation

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 470, P. 143987 - 143987

Published: June 10, 2023

Language: Английский

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Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

The advent of drug-resistant pathogens results in the occurrence stubborn bacterial infections that cannot be treated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating body's immune system to eliminate pathogenic bacteria has confirmed promising therapeutic strategies controlling infections. Subsequent studies found antimicrobial its own benefits and limitations, such as avoiding recurrence infection autoimmunity-induced side effects. Current indicate various antibacterial inducing regulation can achieve superior efficacy compared monotherapy alone. Therefore, summarizing recent advances nanomedicine immunomodulatory functions for combating is necessary. Herein, we briefly introduce crisis caused opportunity immunotherapy. Then, immune-involved multimodal therapy treatment infectious diseases was systematically summarized. Finally, prospects challenges combinational are discussed.

Language: Английский

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The eradication of biofilm for therapy of bacterial infected chronic wound based on pH-responsive micelle of antimicrobial peptide derived biodegradable microneedle patch

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 462, P. 142222 - 142222

Published: March 2, 2023

Language: Английский

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Environment-triggered nanoagent with programmed gas release performance for accelerating diabetic infected wound healing

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 479, P. 147645 - 147645

Published: Nov. 24, 2023

Language: Английский

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Recent advances in Prussian blue-based photothermal therapy in cancer treatment

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(13), P. 4411 - 4429

Published: Jan. 1, 2023

A review discusses the recent applications of Prussian blue nanomaterials in photothermal treatment and photothermal-based multimodal cancer treatment. Additionally, potential obstacles to future research clinical translation are discussed.

Language: Английский

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