H₂S‐Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 2, 2024

Abstract Abnormal activation of the intestinal mucosal immune system, resulting from damage to barrier and extensive invasion by pathogens, contributes pathogenesis inflammatory bowel disease (IBD). Current first‐line treatments for IBD have limited efficacy significant side effects. An innovative H 2 S‐releasing montmorillonite nanoformulation (DPs@MMT) capable remodeling homeostasis, repairing barrier, modulating gut microbiota is developed electrostatically adsorbing diallyl trisulfide‐loaded peptide dendrimer nanogels (DATS@PDNs, abbreviated as DPs) onto (MMT) surface. Upon rectal administration, DPs@MMT specifically binds covers damaged mucosa, promoting accumulation subsequent internalization DPs activated cells in site. release S intracellularly response glutathione, initiating multiple therapeutic In vitro vivo studies shown that effectively alleviates colitis eliminating reactive oxygen species (ROS), inhibiting inflammation, eradicating pathogens. RNA sequencing revealed exerts immunoregulatory repair effects, activating pathways such Nrf2/HO‐1, PI3K‐AKT, RAS/MAPK/AP‐1, p38/ERK MAPK, p65 NF‐κB, JAK‐STAT3 pathways, well glycolysis. 16S rRNA demonstrated remodels pathogens increasing probiotics. This study develops a promising management.

Language: Английский

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A 3-in-1 wearable and implantable biopatch for integrated in-body energy harvesting, sensing, and self-powered diabetic wound treatments

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110743 - 110743

Published: Feb. 1, 2025

Language: Английский

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Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease

Language: Английский

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Catalytic Biomaterials

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(3), P. 271 - 285

Published: Feb. 16, 2024

ConspectusCatalytic biomaterials, an emerging frontier in biomaterials research, offer tremendous potential to circumvent the limitations of traditional treatment approaches, such as low specificity and adverse effects. By harnessing intrinsic physicochemical properties materials, catalytic especially nanoscale (termed nanomedicine), can directly engage with a range biogenic substrates initiate various chemical or biochemical reactions vivo. Chemically designed nanozymes emulate endogenous enzymes regulating intracellular redox homeostasis, offering distinct advantages over their natural counterparts, design flexibility, adjustable functionalities, robust stability harsh conditions, cost-effective production. The extensively investigated mimicked by include peroxidases, oxidases, superoxide dismutases, catalase, glutathione peroxidase. To improve enzyme-mimicking activities properties, composition, size, morphology, exposed crystal facets, surface chemistry, are finely tuned for reactive oxygen species (ROS)-producing pro-oxidative ROS-eliminating antioxidative applications. As interdisciplinary research catalysis biomedicine deepens, cutting-edge concepts catalysis, including single-atom photocatalysis, electrocatalysis, piezoelectric thermoelectric have gradually merged biomaterials. resultant be activated spatiotemporally light, ultrasound, magnetic fields, heat, etc., beyond scope aforementioned endogenously responsive nanozymes. Given semiconductor nature these externally defect engineering heterojunction strategies utilized enhance separation suppress recombination electron–hole pairs modulating bandgap structures. Consequently, efficacy rationally engineered generating scavenging ROS profoundly improved. Apart from ROS-centered applications, content has also been extended transformation substrates, depletion, glucose/lactate consumption, gas production inorganic nanocatalysts. Collectively, which purposefully influence cellular homeostasis regulate cell signaling pathways, assumed play pivotal role addressing spectrum pathophysiological disorders associated oxidative stress dysfunctions, cancer, inflammation, immunomodulation, neurodegeneration, cardiovascular diseases. connections among nanomedicine, nanozymes, we present our insights here clarify distinctions. Catalytic broader scope, spanning nanoscale, microscale, macroscale that possess specific activities. involved encompass both enzyme-mimetic well endogenously/exogenously initiated nanomedicine emphasizes integration nanotechnology therapeutic Nanozymes specifically focus on nanomaterials. Thus, utilize term "catalytic biomaterials" describe this fast-evolving field anticipate will motivate deeper between materials science, medicine.In Account, provide concise introduction fundamental understanding categorizing them into three groups based action mechanisms. Then, highlight group's work fabrication diverse biomedical cancer therapy, antibacterial, anti-inflammation, tissue engineering, regenerative medicine Our primary is deliberate tailor-made application sophisticated scenarios. biological effects arising elucidated. Furthermore, perspectives clinical translation discussed. We envision rapid development could spur evolution highly effective therapeutic/regenerative approaches minimal toxicity wide medical conditions.

Language: Английский

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MXene-based flexible electronic materials for wound infection detection and treatment

npj Flexible Electronics, Journal Year: 2024, Volume and Issue: 8(1)

Published: May 11, 2024

Abstract Wound infection is a worldwide health issue that not only brings large detrimental effects to people’s physical and mental health, but also causes substantial economic burdens society. By using traditional surgical debridement antibiotic therapy, patients generally suffer more pain are at risk of recurring infections. Thus, the development non-antibiotic treatment methods desperately needed. Currently, emerging flexible wound dressings with physiological signal detection, inactivated infectious pathogen, wound-healing promoting properties has exhibited immense potential for infected wound. Among various dressings, MXene‐based electronic materials as special electroactive, mechanical, photophysical, biological performances possess broad application prospect in healthcare. In this review, challenges management introduced. Next, types MXene-based features outlined. Then recent advance detection summarized. Lastly, predicaments, prospects, future directions discussed.

Language: Английский

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Sprayable Hydrogel for pH-Responsive Nanozyme-Derived Bacteria-Infected Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Long-term inflammation and persistent bacterial infection are primary contributors to unhealed chronic wounds. The use of conventional antibiotics often leads bacteria drug resistance, diminishing wound healing effectiveness. Nanozymes have become a promising alternative antimicrobial materials due their low cost, easy synthesis, good stability. Herein, we develop novel sprayable hydrogel based on carboxymethyl chitosan (CMCS) oxidized hyaluronic acid (OHA), incorporating Au nanoparticle-carbon nitride (AuNPs-C3N4) nanozyme, glucose, Mn2+ for bacteria-infected healing. forms rapidly in situ upon spraying gradually degrades the area, releasing AuNPs-C3N4 which exhibits robust glucose oxidase-like (GOx-like) activity, initiating comprehensive catalytic cascade through Mn2+-mediated Fenton-like reaction that generates hydroxyl radicals (•OH) eliminate Staphylococcus aureus (S. aureus) Methicillin-resistant S. (MRSA). Computational results indicate interactions between AuNPs g-C3N4 maximize synergistic effects heterojunction, improving O2 adsorption facilitating electron-O2 optimize activity. Further experiments demonstrate can cover wounds situ, while CMCS promotes collagen production fibroblast proliferation, offering viable strategy

Language: Английский

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Multifunctional injectable hydrogel with self-supplied H2S release and bacterial inhibition for the wound healing with enhanced macrophages polarization via interfering with PI3K/Akt pathway

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123144 - 123144

Published: Jan. 25, 2025

Language: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553

Published: Feb. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Language: Английский

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pH-responsive and on-demand hydrogen sulfide-releasing injectable hydrogel for wound healing promotion

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160904 - 160904

Published: Feb. 1, 2025

Language: Английский

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“Cicada Out of the Shell” Deep Penetration and Blockage of the HSP90 Pathway by ROS‐Responsive Supramolecular Gels to Augment Trimodal Synergistic Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)

Published: April 22, 2024

Abstract Deep penetration and downregulation of heat shock protein (HSP) expression in multimodal synergistic therapy are promising approaches for curing cancer clinical trials. However, free small‐molecule drugs most drug vehicles have a low delivery efficiency deep into the tumor owing to poor hypoxic conditions at site. In this study, objective is use reactive oxygen species (ROS)‐responsive supramolecular gels co‐loaded with photosensitizer Zn(II) phthalocyanine tetrasulfonic acid (ZnPCS 4 ) functionalized tetrahedral DNA (TGSAs) (G@P/TGSAs) enhance tissue cell block HSP90 pathway chemo‐ photodynamic (PDT) ‐ photothermal (PTT) trimodal therapy. The injected situ release ZnPCS TGSAs under high ROS concentrations originating from both PDT. penetrate deeply tissues augment by inhibiting pathway. Proteomics show that HSP‐related proteins molecular chaperones inhibited/activated, Simultaneously, TGSA‐regulated apoptotic activated. vivo study demonstrates efficient excellent (45% growth inhibition).

Language: Английский

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