Picolinamide-assisted ortho-C–H functionalization of pyrenylglycine derivatives using aryl iodides
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(6), P. 1279 - 1298
Published: Jan. 1, 2024
Chemical
transformations
involving
pyrenylglycine
are
seldom
known.
This
paper
reports
the
synthesis
of
C(2)-arylated
(an
unnatural
amino
acid)
motifs
via
a
Pd(
ii
)-catalyzed
C–H
functionalization
and
arylation
in
non-K-region
pyrene.
Language: Английский
Synthesis of biaryl-based carbazoles via C-H functionalization and exploration of their anticancer activities
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(45), P. 8916 - 8944
Published: Jan. 1, 2024
We
described
the
application
of
C–H
functionalization
for
constructing
carbazole-based
biaryls
and
their
anticancer
activities
in
cancer
cell
lines,
e.g.
,
HeLa,
HCT116,
MDA-MB-231
MDA-MB-468
human
embryonic
kidney
line
HEK293T.
Language: Английский
Simple Access to 3-(Hetero)arylated Derivatives of 2-Furoic Acid via Ru(II)-Catalyzed C3-H Arylation of 2-Furoylimidazole
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(19), P. 3063 - 3073
Published: July 16, 2024
Abstract
A
new
approach
for
the
preparation
of
a
variety
3-arylated
2-furoic
acid
derivatives
has
been
developed.
The
involves
selective
Ru-catalyzed
C3-H
arylation
furan
moiety
readily
available
2-furoyl-1-methylimidazole
(using
imidazole
as
removable
N-donor
directing
group),
subsequent
N-methylation,
and
nucleophilic
substitution
with
N,
O,
S,
C
nucleophiles.
Language: Английский
Assembling of Polyaryls (Terphenyls, Tetraphenyls, Pentaphenyls, and Hexaphenyls) through Pd(II)‐catalyzed C−H Arylation of Biaryl Carboxamides with Iodobiaryls
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Nov. 21, 2023
Abstract
A
wide
range
of
polyaryl
compounds
(π‐extended
biaryls)
including
terphenyls,
tetraphenyls,
pentaphenyls,
and
hexaphenyls
were
assembled
in
a
single
operation
Pd(II)‐catalyzed
C−H
coupling
biaryl
carboxamides
iodobiaryls.
Traditionally,
cross‐coupling
protocols
involving
organometallic
reagents
employed
to
assemble
the
core
structure
π‐extended
biaryls
(polyphenylenes
or
polyaryls).
The
pre‐assembling
is
limitation
investigations
pertaining
aryl‐aryl
reactions
affording
polyaryls
(polyphenylenes).
We
report
application
bidentate
directing
group
(DG)‐aided
arylation
method
for
constructing
motifs
using
biaryl‐based
iodobiaryls
as
partners
operation.
current
investigation
on
DG‐aided
with
expected
serve
useful
route
enrich
library
Language: Английский