Highly efficient synthesis of C3-heteroaryl 3-fluorooxindoles via a one-pot stepwise Ce(iii)/photoassisted cross-dehydrogenative coupling/fluorooxidation process DOI
Letian Zhang, Jiajun He, Jiabin Shen

et al.

Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 10(3), P. 668 - 674

Published: Dec. 19, 2022

A one-pot stepwise strategy has been developed to afford C3-heteroaryl 3-fluorooxindoles via a Ce( iii )/photoassisted cross-dehydrogenative coupling/fluorooxidation process in moderate-to-good yields with excellent functional group compatibility.

Language: Английский

State of knowledge in photoredox-catalysed direct difluoromethylation DOI
Jiaxu Feng, Xiaodong Jia,

Shuyue Zhang

et al.

Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(13), P. 3598 - 3623

Published: Jan. 1, 2022

The combination of visible light photoredox catalysis with direct difluoromethylation has allowed the synthesis a large choice CF 2 H-containing value-added molecules under very mild reaction conditions.

Language: Английский

Citations

65
Three‐Component Reactions of Quinoxalin‐2(1H)‐ones: Recent Advances DOI Open Access
Keli Wang,

Hong‐Tao Ji,

Li‐Juan Ou

et al.

European Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 11, 2023

Abstract The multicomponent reactions of quinoxalin‐2(1 H )‐ones has attracted considerable interest due to their significant biological and chemical activities. very recent advances (from 2021 the beginning 2023) on radical three‐component cascade reaction )‐one derivatives at C3 position were summarized in this mini‐review. According kind types involved, some representative examples detailed mechanism have been categorized discussed. red front was covered by Figure 1.

Language: Английский

Citations

36
Phototriggered Self-Catalyzed Phosphorylation of 3,4-Dihydroquinoxalin-2(1H)-ones with Diarylphosphine Oxides in EtOH DOI
Yanfang Jiang, Wen‐Tao Ouyang,

Hong‐Tao Ji

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

A highly effective external photocatalyst- and additive-free method for the phosphorylation of 3,4-dihydroquinoxalin-2(1

Language: Английский

Citations

12
Recent Advances in Visible Light‐Mediated Radical Fluoro‐alkylation, ‐alkoxylation, ‐alkylthiolation, ‐alkylselenolation, and ‐alkylamination DOI Creative Commons
Daniel Lin, Matthew Coe, Vinayak Krishnamurti

et al.

The Chemical Record, Journal Year: 2023, Volume and Issue: 23(9)

Published: May 22, 2023

Abstract In the last few years, many reagents and protocols have been developed to allow for efficient fluorofunctionalization of a diverse set scaffolds ranging from alkanes, alkenes, alkynes, (hetero)arenes. The concomitant rise organofluorine chemistry visible light‐mediated synthesis synergistically expanded fields mutually benefitted developments in both fields. this context, light driven formations radicals containing fluorine major focus discovery new bioactive compounds. This review details recent advances progress made fluoroalkylation heteroatom centered radical generation.

Language: Английский

Citations

20
Visible light induced four component reaction of styrene for the access of thiodifluoroesters DOI

Shaohui Yang,

Jingcheng Song,

Hao Yang

et al.

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 34(9), P. 108131 - 108131

Published: Jan. 5, 2023

Language: Английский

Citations

18
Pd-Catalyzed Divergent Site-Selective Difluoromethylation and Difluoromethylcarbonylation of Aryl Sulfonium Salts DOI

Xujuan Jiang,

Wenbo Gong,

Xiaoxun Li

et al.

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(18), P. 13557 - 13566

Published: Aug. 28, 2024

The incorporation of the difluoromethyl (CF2H) group into arenes has increasingly been recognized as important in drug discovery. Herein, we report a divergent cross-coupling method for constructing both aryl difluoromethanes and difluoroketones from thianthrenium salts. Site selectivity Negishi-type coupling C1 insertion reactions was achieved under palladium catalysis. Both transformations proceed with broad functional tolerance, enabling late-stage difluoromethylation difluoromethylcarbonylation complex molecules. synthetic utility this demonstrated by synthesizing four pharmaceutical analogues same precursor applying it downstream functionalization difluoroketones.

Language: Английский

Citations

7
Difluoromethylation of heterocyclesviaa radical process DOI
Linlin Shi,

Dongdong An,

Guang‐Jian Mei

et al.

Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(15), P. 4192 - 4208

Published: Jan. 1, 2022

In this review, we summarize the state-of-the-art advances in difluoromethylation of heterocycles via a radical process over past few years (2018 to early 2022).

Language: Английский

Citations

24
Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF2H, CF2H+, and:CF2 reactivities DOI

Yuan-Qing Gu,

Hong-Xin Long,

Dandan Zhang

et al.

Science China Chemistry, Journal Year: 2023, Volume and Issue: 67(3), P. 953 - 962

Published: Dec. 27, 2023

Language: Английский

Citations

13
Harnessing photocatalytic and electrochemical approaches for C–H bond trifluoromethylation and fluoroalkylation DOI
Ranjay Shaw, Naveen Sihag, Hemaang Bhartiya

et al.

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 11(3), P. 954 - 1014

Published: Dec. 14, 2023

The review summarises various photo- and electrochemical strategies for trifluoromethylation fluoroalkylation of different C(sp 3 )–H, 2 C(sp)–H bonds in several classes organic molecules.

Language: Английский

Citations

12
Direct C–H alkylation of 3,4-dihydroquinoxaline-2-ones with N-(acyloxy)phthalimides via radical–radical cross coupling DOI

Sudhir Kumar Hota,

Gulshan Singh, Sandip Murarka

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(49), P. 6268 - 6271

Published: Jan. 1, 2024

An organophotoredox-catalyzed direct Csp 3 –H alkylation of 3,4-dihydroquinoxalin-2-ones employing N -(acyloxy)phthalimides to provide corresponding products in good yields is described.

Language: Английский

Citations

4