Recent Advances in Transition Metal Catalyzed Synthesis of C3-Substitution-free 2-Oxindole Derivatives DOI
Partha Pratim Das, Debapratim Das

Mini-Reviews in Organic Chemistry, Journal Year: 2023, Volume and Issue: 21(6), P. 599 - 608

Published: Aug. 22, 2023

Abstract: 2-Oxindole unit is one of the most important scaffolds found in several alkaloids, natural products, antitumor agents, pharmaceutically compounds, etc. Molecules containing 2- oxindole moiety were first isolated from cat claw plant, widely distributed Amazon jungle. It has now been demonstrated that these molecules are present a wide range chemicals derived plant sources. The capacity 2-oxindole to be altered by various chemical groups provide unique biological activities can attributed its function as framework for creating and developing medications. Since development synthetic methodology, research have developed protocols producing core bioactive derivatives. These include traditional method transition/non-transition metal-catalyzed pathway synthesis C3-non-substituted/C3-mono-substituted/C3-di-substituted core. Among those, C3-substitution-free quite challenging task, C3-centre very reactive. Syntheses cores less explored compared other substituted In this review article, we mainly focused on showcasing transition methodology 2-oxindoles with no substitution at C3-centre.

Language: Английский

N-Heterocyclic nitrenium catalyzed photosynthesis of 3,3-disubstituted oxindoles from α-chloroanilides DOI

Kun‐Quan Chen,

Jia Zhang,

Dequn Sun

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

A photoinduced N-heterocyclic nitrenium-catalyzed strategy for the synthesis of 3,3-oxindoles from α-chloroanilides under transition-metal-free conditions was reported.

Language: Английский

Citations

1
Metal- and light-free approach to polyheterocycles via a quinone-Cs2CO3 couple promoted regioselective cascade radical cyclization DOI Creative Commons

Qijing Zhang,

Pan Yue, Hao Lei

et al.

Green Synthesis and Catalysis, Journal Year: 2023, Volume and Issue: 5(3), P. 195 - 199

Published: April 3, 2023

A highly efficient, transition-metal- and light-free approach to polyheterocycles via regioselective cascade radical cyclization is developed. The redox-neutral protocol has a broad substrate scope with good functional group tolerance probably undergoes SET process, which initiated by catalytic amounts of quinone in combination 2.0 equiv. Cs2CO3.

Language: Английский

Citations

2
Recent Advances in Transition Metal Catalyzed Synthesis of C3-Substitution-free 2-Oxindole Derivatives DOI
Partha Pratim Das, Debapratim Das

Mini-Reviews in Organic Chemistry, Journal Year: 2023, Volume and Issue: 21(6), P. 599 - 608

Published: Aug. 22, 2023

Abstract: 2-Oxindole unit is one of the most important scaffolds found in several alkaloids, natural products, antitumor agents, pharmaceutically compounds, etc. Molecules containing 2- oxindole moiety were first isolated from cat claw plant, widely distributed Amazon jungle. It has now been demonstrated that these molecules are present a wide range chemicals derived plant sources. The capacity 2-oxindole to be altered by various chemical groups provide unique biological activities can attributed its function as framework for creating and developing medications. Since development synthetic methodology, research have developed protocols producing core bioactive derivatives. These include traditional method transition/non-transition metal-catalyzed pathway synthesis C3-non-substituted/C3-mono-substituted/C3-di-substituted core. Among those, C3-substitution-free quite challenging task, C3-centre very reactive. Syntheses cores less explored compared other substituted In this review article, we mainly focused on showcasing transition methodology 2-oxindoles with no substitution at C3-centre.

Language: Английский

Citations

1