Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Comprehensive
Summary
Two
reaction
modes
for
metal‐free
[3
+
2]
cyclization
of
N
‐aminopyridinium
derivatives
with
β
‐alkoxyvinyl
trifluoromethylketones
have
been
described
through
selective
C—O
or
C—O/C—C
bond
cleavage.
This
strategy
can
also
be
extended
to
the
enaminones
and
bromoalkynes.
A
broad
range
‐aminopyridinium,
‐aminoquinolinium,
‐aminoisoquinolinium
salts
are
well
tolerated,
enabling
divergent
synthesis
trifluoroacylated,
non‐substituted,
acylated,
brominated
pyrazolo[1,5‐
a
]pyridine
(62
examples).
Current Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
28(2), P. 117 - 133
Published: Jan. 1, 2024
Abstract:
The
focus
of
this
review
is
on
the
synthetic
routes
available
for
different
types
pyrazoloquinoline
derivatives.
There
are
three
methods:
i)
from
pyrazole
derivatives;
ii)
quinoline
and
iii)
miscellaneous
methods.
position
linkage
between
rings
determines
seven
isomers
pyrazoloquinolines.
purpose
to
provide
a
guide
both
medicinal
chemists
discover
design
new
pyrazoloquinolines
medical
purposes.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(14), P. 3827 - 3832
Published: Jan. 1, 2024
A
visible-light-induced
[3
+
2]
annulation
of
N
-tosylimino(iso)quinolinium
ylides
with
aryl
olefins,
catalyzed
by
a
bisphosphonium
salt
has
been
developed.
Furthermore,
the
synthesis
method
salts
was
improved.
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 28, 2024
Abstract
Organoboron
compounds
are
recognized
as
essential
synthetic
intermediates
in
organic
chemistry
and
have
found
broad
applications
pharmaceutical
materials
science.
In
recent
years,
the
development
of
novel
boronating
reagents
has
opened
new
avenues
for
synthesis
organoboron
compounds.
Among
these,
N-heterocyclic
carbene
boranes
(NHC-boranes),
with
their
unique
advantages,
garnered
sustained
interest
evolved
into
important
precursors
boron-centered
radicals,
participating
a
diverse
array
visible-light-induced
borylation
reactions.
This
short
review
primarily
focuses
on
radical
reactions
involving
NHC-boranes,
summarizing
latest
advancements
field
offering
inspiration
subsequent
research.
1
Introduction
2
Photoinduced
Borylation
via
NHC-Boryl
Radicals
2.1
Polyfluoroarenes
2.2
Arenes
2.3
Alkenes
2.4
Alkynes
2.5
Other
Substrates
3
Conclusion
Future
Prospects
The Chemical Record,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 22, 2024
Abstract
Indolizines
and
imidazo[1,2‐
a
]pyridines
are
commonly
found
in
natural
products,
synthetic
drugs,
bioactive
molecules.
These
two
types
of
derivatives
possess
good
antibacterial,
antiparasitic,
anticancer
activities,
so
on.
The
functionalization
indolizines
has
always
been
hot
topic
organic
chemistry
research
made
significant
progress.
In
recent
years,
our
group
dedicated
to
developing
diverse
methods
for
the
preparation
such
important
compounds.
1)
We
have
developed
C−H
reactions
efficient
modification
parent
]pyridines.
2)
A
variety
cycloaddition
were
established
construction
indolizine
]pyridine
from
simple
raw
materials.
3)
intriguing
deconstruction‐functionalization
indolizines,
enabling
reorganization
heterocyclic
frameworks.
This
paper
outlines
group's
latest
advancements
constructing
structurally
derivatives.
hope
that
this
work
will
offer
valuable
insights
inspiration
ongoing
field
N‐heterocyclic
Journal of Heterocyclic Chemistry,
Journal Year:
2024,
Volume and Issue:
61(7), P. 1200 - 1205
Published: May 22, 2024
Abstract
A
practicable
method
is
described
for
the
synthesis
of
3‐acyl‐pyrazolo[1,5‐
a
]pyridines
from
N
‐aminopyridines
and
easily
available
enaminones
via
[3+2]
cycloaddition.
The
reactions
proceed
well
with
broad
scope,
without
using
additive
(base
or
oxidant).
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
88(1), P. 75 - 85
Published: Dec. 20, 2022
Here,
we
report
a
facile
and
metal-free
method
for
the
construction
of
dihydrooxazine
derivatives
via
formal
(3
+
3)
annulation
reaction
naphthols
1,3,5-triazinanes.
The
1,3,5-triazinanes
were
utilized
as
three-atom
synthon
(C-N-C)
cycloaddition.
In
addition,
dihydrothiazine
tetrahydrobenzoquinazoline
could
also
be
produced
in
good
yields
by
this
strategy
under
catalyst-free
additive-free
conditions.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
19(4)
Published: Nov. 29, 2023
Abstract
A
palladium‐catalyzed
reaction
for
intermolecular
selective
C−H
cyclocarbonylation
of
2
‐
iodobiphenyls
is
described.
Intriguingly,
the
vinylene
carbonate
acts
as
a
carbon
monoxide
transfer
agent
to
enable
annulation
reaction.
Moreover,
versatile
synthon,
fluoren‐9‐one
can
be
transformed
into
variety
functionalized
organic
molecules,
such
[1,1′‐biphenyl]‐2‐carboxylic
acid,
1′
H
,3′
‐spiro[fluorene‐9,2′‐perimidine]
and
N
‐tosylhydrazones.
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
48(28), P. 12496 - 12500
Published: Jan. 1, 2024
A
method
for
the
construction
of
2-fluoropyrazolo[1,5-
a
]pyridines
through
base-promoted
[3+2]
cycloaddition
N
-aminopyridinium
salts
with
gem
-difluorostyrenes
has
been
established.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Comprehensive
Summary
Two
reaction
modes
for
metal‐free
[3
+
2]
cyclization
of
N
‐aminopyridinium
derivatives
with
β
‐alkoxyvinyl
trifluoromethylketones
have
been
described
through
selective
C—O
or
C—O/C—C
bond
cleavage.
This
strategy
can
also
be
extended
to
the
enaminones
and
bromoalkynes.
A
broad
range
‐aminopyridinium,
‐aminoquinolinium,
‐aminoisoquinolinium
salts
are
well
tolerated,
enabling
divergent
synthesis
trifluoroacylated,
non‐substituted,
acylated,
brominated
pyrazolo[1,5‐
a
]pyridine
(62
examples).
