Authorea (Authorea),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Aug. 16, 2023
A
one-pot
synthesis
of
vicinal
diamines
using
indoles,
pyrazoles,
and
phenothiazines
in
a
tandem
multi-component
reaction
is
developed.
The
utilization
copper-iodine
co-catalytic
system
enables
the
generation
diverse
range
diaminoindoles
with
good
selectivity
moderate
to
yields.
An
attractive
aspect
this
method
that
it
can
be
conducted
under
mild
environmentally
friendly
conditions,
showcasing
its
potential
as
an
alternative
approach
for
synthesizing
diamines.
Moreover,
use
multicomponent
highlights
power
versatility
such
strategies
synthetic
chemistry.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(17), P. 10192 - 10280
Published: Aug. 8, 2024
Radical
C–H
functionalization
represents
a
useful
means
of
streamlining
synthetic
routes
by
avoiding
substrate
preactivation
and
allowing
access
to
target
molecules
in
fewer
steps.
The
first-row
transition
metals
(Ti,
V,
Cr,
Mn,
Fe,
Co,
Ni,
Cu)
are
Earth-abundant
can
be
employed
regulate
radical
functionalization.
use
such
is
desirable
because
the
diverse
interaction
modes
between
metal
complexes
species
including
addition
center,
ligand
complexes,
substitution
single-electron
transfer
radicals
hydrogen
atom
noncovalent
complexes.
Such
interactions
could
improve
reactivity,
diversity,
selectivity
transformations
allow
for
more
challenging
reactions.
This
review
examines
achievements
this
promising
area
over
past
decade,
with
focus
on
state-of-the-art
while
also
discussing
existing
limitations
enormous
potential
high-value
regulated
these
metals.
aim
provide
reader
detailed
account
strategies
mechanisms
associated
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(9), P. 1152 - 1155
Published: Jan. 1, 2024
An
efficient
approach
for
the
selective
construction
of
C2,3-
or
C2,5-aminochalcogenated
indole
derivatives
has
been
developed,
which
enables
oxidative
regioselective
aminochalcogenation
indolines
with
amines
and
dichalconides.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(34), P. 4613 - 4616
Published: Jan. 1, 2024
We
report
an
innovative
synthetic
strategy
for
the
generation
of
polysubstituted
indoles
from
indolines,
aryldiazonium
salts,
and
azoles.
The
methodology
encompasses
electrophilic
substitution
reaction
affording
C5-indoline
intermediates
which
undergo
iodine-mediated
oxidative
transformation
coupled
with
C-H
functionalization
to
yield
indole
derivatives.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(21), P. 15106 - 15117
Published: Oct. 21, 2023
A
metal-free
one-pot
oxidative
cross-dehydrogenation
coupling
reaction
for
the
formation
of
C-N/C-C
bonds
at
C2,3-positions
indoles
with
azoles
and
quinoxalinones
has
been
developed.
The
proposed
method
several
notable
features,
including
catalysis,
use
N-H
free
as
substrates,
ease
operation,
mild
conditions,
compatibility
a
wide
range
substrates.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(14), P. 10272 - 10282
Published: July 5, 2024
The
exploration
of
remote
functionalization
indoles
is
impeded
by
the
inherently
dominant
reactivity
intrinsic
to
pyrrole
moiety.
Herein,
we
delineate
a
novel
strategy
facilitated
Lewis
acid
mediation,
enabling
C-H
functionalization,
which
culminates
in
synthesis
an
array
selectively
functionalized
indole
derivatives,
encompassing
3-trifluoroacetyl
and
5-benzoyl
motifs,
utilizing
trifluoroacetic
anhydride
various
acyl
chlorides.
Notably,
protocol
exhibits
versatility,
as
epitomized
extension
C5-acylation
alkylation
sulfonation
reactions.
This
methodology
distinguished
its
exemplary
regio-
chemo-selectivity,
extensive
substrate
scope,
commendable
tolerance
diverse
functional
groups,
employment
comparatively
mild
reaction
conditions.
A
novel
one-pot
oxidative
cross-dehydrogenation
coupling
(CDC)
reaction
has
been
developed
for
the
selective
construction
of
C–N
and
C–C
bonds
at
C2,3-positions
indoles.
Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
41(24), P. 3567 - 3572
Published: Aug. 28, 2023
Comprehensive
Summary
A
one‐pot
synthesis
of
vicinal
diamines
using
indoles,
azoles
and
phenothiazines
in
a
tandem
multi‐component
reaction
is
developed.
The
utilization
copper‐iodine
co‐catalytic
system
enables
the
generation
diverse
range
diaminoindoles
with
good
selectivity
moderate
to
yields.
An
attractive
aspect
this
method
that
it
can
be
conducted
under
mild
environmentally
friendly
conditions,
showcasing
its
potential
as
an
alternative
approach
for
synthesizing
diamines.
Moreover,
use
multicomponent
highlights
power
versatility
such
strategies
synthetic
chemistry.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(7), P. 1933 - 1940
Published: Jan. 1, 2024
A
new
one-pot
method
for
solvent-controlled
switchable
tandem
oxidative
triple
functionalization
of
indolines
has
been
developed
via
successive
regioselective
chalcogenation,
oxidation,
amination
and
halogenation.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(10), P. 7216 - 7224
Published: May 2, 2024
An
organoselenium-catalyzed
C2,3-diarylation
of
unprotected
N–H
indoles
with
electron-rich
aromatics
has
been
developed.
This
one-pot
multicomponent
tandem
cross-dehydrogenation
coupling
reaction
allows
for
the
incorporation
two
different
aromatic
groups
to
indoles.
More
importantly,
this
approach
offers
significant
advantages,
including
a
high
atom
and
step
economy,
eliminating
need
prepreparation
substrates,
streamlining
synthetic
process
enhancing
its
practicality.
Overall,
presents
an
efficient
versatile
strategy
functionalization
indole
derivatives.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(23), P. 6819 - 6849
Published: Jan. 1, 2024
This
review
highlights
recent
advances
in
the
atroposelective
preparation
of
axially
chiral
azole
derivatives,
emphasizing
mechanistic
insights
and
synthetic
applications
development
this
class
five-membered
heterocyclic
frameworks.
