Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 25, 2025
A
modular
synthesis
method
for
1,4-diketones
has
been
developed.
Utilizing
inexpensive
carboxylic
acid
esters
as
carbonyl
sources
and
tetraborylethane
(TBE)
a
nucleophilic
reagent,
one-pot
strategy
constructing
two
C-C
bonds
was
established.
Notably,
this
reaction
proceeds
without
the
involvement
of
transition
metals
exhibits
excellent
functional
group
compatibility.
diverse
array
α-substituted
were
synthesized
using
various
electrophiles
capture.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(18), P. 4488 - 4515
Published: Jan. 1, 2023
This
review
highlights
the
recent
advances
in
radical
acylated
difunctionalization
of
unsaturated
carbon–carbon
bonds
and
focuses
on
mechanistic
insights
these
transformations.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Dec. 2, 2023
We
report
a
combination
of
electrocatalysis
and
photoredox
catalysis
to
perform
selective
C(sp3)-H
arylation/alkylation
alkanes,
in
which
binary
catalytic
system
based
on
earth-abundant
iron
nickel
is
applied.
Reaction
selectivity
between
two-component
arylation
three-component
alkylation
tuned
by
modulating
the
applied
current
light
source.
Importantly,
an
ultra-low
anodic
potential
(~0.23
V
vs.
Ag/AgCl)
this
protocol,
thus
enabling
compatibility
with
variety
functional
groups
(>70
examples).
The
robustness
method
further
demonstrated
preparative
scale
late-stage
diversification
natural
products
pharmaceutical
derivatives.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(16), P. 5373 - 5387
Published: Jan. 1, 2023
The
chemistry
and
the
reaction
mechanisms
behind
four
catalytic
protocols
currently
available
for
visible
light-induced
C–C
cross-coupling
by
activation
of
C
sp
3
–H
bonds
are
described.
Organic Process Research & Development,
Journal Year:
2023,
Volume and Issue:
27(3), P. 423 - 447
Published: Feb. 17, 2023
Nonprecious-metal-catalyzed
alternatives
to
powerful
precious
metal
transformations
are
of
increasing
interest
in
academia
and
the
pharmaceutical
industry
due
lower
cost,
better
sustainability,
toxicity.
With
continual
growth
broad
field
nonprecious
catalysis
(NPMC),
we
have
chosen
highlight
selected
articles
published
from
March
June
2022
which
intended
examples
NPMC
that
feel
may
be
especially
relevant
development.
We
aim
inspire
academic
industrial
innovation
through
discussion
herein.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(14), P. 4024 - 4040
Published: Jan. 1, 2024
This
review
provides
a
comprehensive
overview
of
metal
catalysis
in
photo-electrochemical
systems,
discussing
reaction
mechanisms
and
offering
prospects
for
this
triadic
catalytic
mode.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(17), P. 10192 - 10280
Published: Aug. 8, 2024
Radical
C–H
functionalization
represents
a
useful
means
of
streamlining
synthetic
routes
by
avoiding
substrate
preactivation
and
allowing
access
to
target
molecules
in
fewer
steps.
The
first-row
transition
metals
(Ti,
V,
Cr,
Mn,
Fe,
Co,
Ni,
Cu)
are
Earth-abundant
can
be
employed
regulate
radical
functionalization.
use
such
is
desirable
because
the
diverse
interaction
modes
between
metal
complexes
species
including
addition
center,
ligand
complexes,
substitution
single-electron
transfer
radicals
hydrogen
atom
noncovalent
complexes.
Such
interactions
could
improve
reactivity,
diversity,
selectivity
transformations
allow
for
more
challenging
reactions.
This
review
examines
achievements
this
promising
area
over
past
decade,
with
focus
on
state-of-the-art
while
also
discussing
existing
limitations
enormous
potential
high-value
regulated
these
metals.
aim
provide
reader
detailed
account
strategies
mechanisms
associated
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(14), P. 8315 - 8322
Published: Jan. 1, 2024
A
photoelectrochemical
approach
for
the
carboacylation/silanoylation
of
alkenes
with
alkanes/hydrosilanes
is
described.
The
method
offers
a
new
perspective
chemists
to
rapidly
obtain
various
ketones
high
levels
structural
complexity.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(23), P. 6449 - 6456
Published: Jan. 1, 2023
By
merging
nickel-mediated
facially
selective
aza-Heck
cyclization
and
radical
acyl
C-H
activation
promoted
by
tetrabutylammonium
decatungstate
(TBADT)
as
a
hydrogen
atom
transfer
(HAT)
photocatalyst,
we
accomplish
an
asymmetric
imino-acylation
of
oxime
ester-tethered
alkenes
with
readily
available
aldehydes
the
source,
enabling
synthesis
highly
enantioenriched
pyrrolines
bearing
acyl-substituted
stereogenic
center
under
mild
conditions.
Preliminary
mechanistic
studies
support
Ni(i)/Ni(ii)/Ni(iii)
catalytic
sequence
involving
intramolecular
migratory
insertion
tethered
olefinic
unit
into
Ni(iii)-N
bond
enantiodiscriminating
step.
