Angewandte Chemie,
Journal Year:
2023,
Volume and Issue:
135(38)
Published: Aug. 3, 2023
Abstract
Aliphatic
trifluoromethyl
ketones
are
a
type
of
unique
fluorine‐containing
subunit
which
play
significant
role
in
altering
the
physical
and
biological
properties
molecules.
Catalytic
methods
to
provide
direct
access
aliphatic
highly
desirable
yet
remain
underdeveloped,
partially
owing
high
reactivity
instability
trifluoroacetyl
radical.
Herein,
we
report
photocatalytic
synthesis
from
alkyl
bromides
with
trifluoroacetic
anhydride.
The
reaction
features
dual
visible‐light
halogen‐atom‐transfer
catalysis,
followed
by
an
enabling
radical‐radical
cross‐coupling
radical
stabilized
provides
straightforward
readily
available
cost‐effective
halides
anhydride
(TFAA).
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(38)
Published: Aug. 3, 2023
Aliphatic
trifluoromethyl
ketones
are
a
type
of
unique
fluorine-containing
subunit
which
play
significant
role
in
altering
the
physical
and
biological
properties
molecules.
Catalytic
methods
to
provide
direct
access
aliphatic
highly
desirable
yet
remain
underdeveloped,
partially
owing
high
reactivity
instability
trifluoroacetyl
radical.
Herein,
we
report
photocatalytic
synthesis
from
alkyl
bromides
with
trifluoroacetic
anhydride.
The
reaction
features
dual
visible-light
halogen-atom-transfer
catalysis,
followed
by
an
enabling
radical-radical
cross-coupling
radical
stabilized
provides
straightforward
readily
available
cost-effective
halides
anhydride
(TFAA).
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(3), P. 607 - 612
Published: Jan. 11, 2024
An
electrochemical
approach
to
biheteroaryls
through
the
coupling
of
diverse
N-heteroarenes
with
heteroaryl
phosphonium
salts
is
reported.
The
reaction
features
pH
and
redox-neutral
conditions
excellent
regioselectivity,
as
well
exogenous
air
or
moisture
tolerance.
Additionally,
a
one-pot,
two-step
protocol
can
be
established
realize
formal
C–H/C–H
heteroarenes,
thereby
greatly
expanding
substrate
availability.
utility
this
method
demonstrated
late-stage
functionalization,
total
synthesis
nitraridine,
antifungal
activity
studies.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(11), P. 1756 - 1764
Published: Jan. 25, 2024
Abstract
A
facile
and
efficient
method
for
the
synthesis
of
trifluoromethylated
carbinols
has
been
developed
from
imidazo[1,2-a]pyridines
trifluoroacetaldehyde.
The
direct
C(sp2)–H
hydroxytrifluoromethylation
is
successfully
implemented
at
room
temperature
using
HFIP
as
solvent
through
dehydrative
cross-coupling
process,
which
displays
a
broad
substrate
scope
functional
group
tolerance.
Furthermore,
gram-scale
synthetic
transformation
experiments
have
also
demonstrated,
indicate
its
potential
applicable
values
in
organic
synthesis.
This
green
protocol
features
operational
simplicity,
atom
economy,
mild
reaction
conditions
(e.g.,
temperature,
transition-metal-
oxidant-free,
without
inert
gas
protection),
wide
scope,
excellent
practicality.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(22), P. 4390 - 4419
Published: Jan. 1, 2024
The
merger
of
organic
electrosynthesis
with
3d
transition-metal
catalysis
has
offered
huge
opportunities
for
modern
synthesis.
This
review
summarizes
the
key
advancements
in
this
direction
published
recent
two
years.
Communications Chemistry,
Journal Year:
2023,
Volume and Issue:
6(1)
Published: Sept. 1, 2023
Alkanes
are
naturally
abundant
chemical
building
blocks
that
contain
plentiful
C(sp3)-H
bonds.
While
inert,
the
activation
of
via
hydrogen
atom
abstraction
(HAT)
stages
an
appealing
approach
to
generate
alkyl
radicals.
However,
prevailing
shortcomings
include
excessive
use
oxidants
and
alkanes
impede
scope.
We
herein
show
gallium
nitride
(GaN)
as
a
non-toxic,
recyclable,
heterogeneous
photocatalyst
enable
in
conjunction
with
catalytic
simple
photosensitizer,
benzophenone,
promote
desired
radical
generation.
The
dual
photocatalytic
cycle
enables
cross-dehydrogenative
Minisci
alkylation
under
mild
oxidant-free
conditions.
Synthesis,
Journal Year:
2023,
Volume and Issue:
55(18), P. 3026 - 3032
Published: Aug. 2, 2023
Abstract
An
electrochemical
approach
for
the
Minisci-type
acylation
of
quinoxalines
with
α-keto
acids
as
acyl
radical
precursors
is
reported.
With
assistance
TFA
key
additive,
acylated
were
constructed
in
synthetically
useful
yields.
The
distinguishable
features
this
protocol
include
catalyst-
and
external
oxidant-free
conditions,
operational
simplicity.
