Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
The
reconstruction
of
tendons
with
large
defects
requires
grafts
high
mechanical
strength
and
is
often
hindered
by
complications
such
as
infection
adhesion.
Hence,
combining
the
advantages
resilience
antibacterial/antiadhesion
activity
are
highly
sought
after.
silver
nanoparticles
(GA-Ag
NPs)
synthesized
from
gallic
acid
nitrate
were
attached
to
a
decellularized
extracellular
matrix
(Decellularized
Tendon
crosslinking
GA-AgNPs,
DT-Ag).
We
examined
histological
structure,
property,
morphology,
Zeta
potential,
cytotoxicity,
antibacterial
properties,
antioxidant
anti-inflammatory
ability
DT-Ag
treat
tendon
in
animals.
Approximately
108.57
±
0.94
μg
GA-Ag
NPs
loaded
per
50
mg
DT,
cross-linked
part
was
65.47
0.57%,
which
provided
long-lasting
activity.
Meanwhile,
GA
endowed
good
activities.
Additionally,
facilitated
M2
macrophage
polarization,
suppressed
fibrin
deposition
hindering
fibroblast
Mormore,
main
DT-Ag,
namely
its
(tested
using
Escherichia
coli
Staphylococcus
aureus
models)
prevent
tissue
adhesion
confirmed
vivo.
fabricated
multifunctional
graft
hydrophilic,
biocompatible,
mechanically
resilient,
concluded
be
well
suited
for
dealing
surgical
has
bright
application
prospects.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(1)
Published: Sept. 15, 2023
Abstract
Physical
cues
like
morphology,
light,
electric
signal,
mechanic
magnetic
and
heat
can
be
used
as
alternative
regulators
for
expensive
but
short‐acting
growth
factors
in
bone
tissue
engineering
to
promote
osteogenic
differentiation
regeneration.
As
physical
stimulation
applied
directly
the
cannot
focused
on
defect
area
regulate
cell
behaviors
fate
situ,
this
limits
efficiency
of
precise
Biomaterials‐mediated
situ
cues,
an
effective
strategy
combining
synergistic
effect
materials
themselves,
are
put
forward
studied
widely
repair
efficiently
precisely.
Different
types
provide
different
choices
better
satisfy
requirements
targeted
repair.
In
review,
recent
research
about
biomaterials‐mediated
accelerating
osteogenesis
vitro
promoting
formation
vivo
is
introduced.
Meanwhile,
corresponding
possible
mechanisms
various
regulating
responses
also
discussed.
This
review
provides
useful
enlightening
guidance
utilization
intrinsically
properties
functional
achieve
efficient
regeneration,
leading
design
construction
smart
biomaterials
practical
applications,
eventually
clinical
translation.
BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 29, 2024
Abstract
The
emergence
of
multidrug‐resistant
bacteria
poses
a
significant
challenge
in
the
treatment
osteomyelitis,
rendering
traditional
antibiotic
strategies
inadequate
terms
achieving
complete
cure.
In
recent
years,
triggerable
biomaterial‐based,
antibiotic‐free
osteomyelitis
have
rapidly
evolved,
demonstrating
excellent
bactericidal
effects.
Triggerable
biomaterials‐based
theranostics
encompass
physical
signal
response
and
host
immune
modulation
approaches.
These
can
be
effective
against
drug‐resistant
bacteria,
circumventing
gradual
acquisition
resistance
that
often
accompanies
treatment.
Additionally,
inherent
properties
biomaterials
facilitate
precise
imaging
osteomyelitis.
There
is
no
doubt
biomaterial‐mediated,
therapies
are
emerging
as
trend,
which
critically
important
combating
bacteria‐induced
this
review,
we
summarize
latest
advances
from
both
pathogen‐directed
host‐directed
perspectives.
design
regimens
specific
action
mechanisms
biomaterial‐based
nanoplatforms
also
clarified.
Finally,
outline
challenges
faced
by
various
provide
an
outlook
on
prospects
for
synergistic
interactions.
Materials Advances,
Journal Year:
2025,
Volume and Issue:
6(3), P. 1107 - 1118
Published: Jan. 1, 2025
A
Logic
OR-gate
plasmonic
biosensor,
composed
of
an
array
antibody-functionalized
gold
nanorods
with
multipathogen
detection
capabilities
and
photothermal
disinfection
properties
for
potable
water,
is
presented.
Health Science Reports,
Journal Year:
2023,
Volume and Issue:
6(8)
Published: Aug. 1, 2023
As
the
world
struggles
to
recover
from
recent
COVID
pandemic,
antimicrobial
resistance
(AMR)
is
proving
be
a
new
threat
human
health,
food
security,
and
economic
development.
According
World
Health
Organization
(WHO),
multidrug-resistant
pathogens/superbugs
are
considered
serious
worldwide.
The
Interagency
Coordinating
Group
on
AMR
has
estimated
that
by
2050,
mortality
rate
due
may
increase,
with
an
annual
death
of
approximately
10
million
people.
term
multidrug
resistant
pathogens
refers
those
bacteria,
viruses,
fungi,
or
parasites
become
standard
treatment
no
longer
respond
inappropriate
use
drugs,
consumption
unhygienic
food,
poor
sanitary
conditions,
infection
prevention,
so
forth.1
rapid
emergence
newly
evolved
mechanisms
low
efficacy
drugs/treatments
against
repeated
microbial
infections
lead
prolonged
illness,
high
health
care
costs,
worsening
disease,
increased
risk
death.
In
last
few
decades,
most
infectious
agents
such
as
have
developed
levels
morbidity
therefore
referred
"superbugs."
Usually,
superbugs
natural
phenomenon,
however
increases
in
immunodeficient
like
diabetes,
severe
burn
patients,
HIV
infection,
organ
transplant
recipients,
forth.
list
published
WHO
several
types
bacteria
rapidly
developing
antibiotics
these
been
categorized
into
three
priority
groups
including
Acinetobacter
baumannii
(carbapenem
resistant),
Pseudomonas
aeruginosa
Enterobacteriaceae
Extended-spectrum
beta-lactamases
producing
1
pathogens;
Neisseria
gonorrhoeae
(cephalosporin
fluoroquinolone
Enterococcus
faecium
(vancomycin
nontyphoidal
Salmonella
(fluoroquinolones
Staphylococcus
aureus
(methicillin
vancomycin
Helicobacter
pylori
(clarithromycin
Campylobacter
spp.
(fluoroquinolone
resistant)
2
Haemophilus
influenzae
(ampicillin
Shigella
species
Streptococcus
pneumoniae
(penicillin
3
(https://www.who.int/en/news-room/detail/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed;
Accessed
07/Nov/2022).
Along
them,
Klebsiella
(carbapenems
cephalosporin
Escherichia
coli
Mycobacterium
tuberculosis
(fluoroquinolone,
rifampicin,
isoniazid
showed
highest
rates.
Infections
caused
fungal
growth
treated
antifungal
drugs
Deoxyribonucleic
Ribonucleic
acid
synthesis
inhibitors
(flucytosine),
azole
derivatives
(itraconazole,
voriconazole,
ketoconazole,
fluconazole),
1,3-β-glucan
synthase
(echinocandins),
polyene
macrolides
(amphotericin
B),
although
strains
Trichosporon
beigelii,
Aspergillus
spp.,
Cryptococcus
neoformans,
Candida
Scopulariopsis
forth,
gained
drugs.2
Parasitic
Leishmania,
Entamoeba,
Plasmodia,
Toxoplasma
gondiischi,
Trichomonas
vaginalis
amphotericin
B,
artemisinin,
miltefosine,
paromomycin,
chloroquine,
pyrimethamine.1
Due
extensive
constant
viral
replication,
many
viruses
also
drug
over
years,
herpes
simplex
virus,
hepatitis
B
C
influenza
A
HIV,
cytomegalovirus,
varicella-zoster
SARS-CoV-2,
raising
concern
antiviral
immunocompromised
patients.3-6
These
capable
causing
percentage
hospital
acquired
can
turn
common
pneumonia,
bloodstream
infections,
urinary
tract
fatal
diseases
deadly
patients.
COVID-19
which
spread
uncontrollably
different
parts
world,
reported
up
532
positive
cases,
6
deaths
worldwide,
till
June
2022.7
Although,
it
seems
we
winning
battle
COVID,
believed
future
will
face
related
issues
this
pandemic.
One
biggest
excessive
increased,
now
diseases.8-10
some
mild
cases
COVID-19,
observed
there
increase
vulnerability
patients
illness
co-infection
pathogenic
microbes.11,
12
Posterarao
et
al.13
diabetes
mellitus
(type
2)
suffered
glabrata
other
fungi.
Another
report
suggests
strain
fumigatus
worsened
condition
suffering
acute
infection.14
Cebeci
Kahraman
al.15
cutaneous
systemic
adverse
reactions
vaccinated
Turkey
region.
study
included
2290
Pfizer/BioNTech
(BNT162b2)
Sinovac/CoronaVac
(inactivated
SARS-CoV2)
vaccines,
result
zoster,
anaphylaxis,
triggered
autoimmunity
appeared
CoronaVac
vaccine.15
another
Vinayagamoorthy
al.16
revealed
invasive
medical
measures
disease
itself
make
them
more
susceptible
auris.
Although
techniques
approaches
bio-nanotechnology
approaches,
polymeric
biomaterials
products,
combinational
years
combat
various
AMR.17
Natural
products
extensively
researched
pathogens.
Geraniol,
neral,
1,8-cineole,
camphene,
alpha-curcumene
beta-phellandrene
isolated
Zingiber
officinale
shown
antibacterial
properties
18
pathogens.18
Lariciresinol
berberine
Z.
significant
activity
enterica
serovar
typhimurium.19
Phenols
flavonoids
obtained
Vernonia
auriculifera
Hiern
E.
coli,
Enterobacter
aerogenes,
K.
pneumoniae,
P.
S.
aureus.20
Pleuromutilin,
azamulin,
valnemulin,
tiamulin
reptapamulin
Methicillin-resistant
aureus.21
addition,
metal
oxide
nanoparticles
activity.
Aunkor
al.22
graphene
nanosheet
superbug
Roy
al.23
prominent
photothermal
therapy
superbugs.
Zinc
prepared
fruits
leaves
Limonia
acidissima
pneumonia'
Shigella,
Streptococus,
staphylococcus
paratyphi.24
Silver
synthesized
Aloe
vera
aureus,
pseudomonas,
A.
strains.25
Over
time,
sharp
reduction
approval
antimicrobials.
Dalbavancin,
oritavancin,
meropenem
vaborbactam,
eravacycline,
pretomanid,
cefiderocol,
plazomicin,
delafloxacin
tedizolid
recently
approved
antibiotics.26
under
development
fosmanogepix,
tetrazoles
(VT-1129,
1161,
1598),
Aureobasidin
A,
F901318,
T-2307,
VL-2397.27
2020
only
52
compounds
were
preclinical
clinical
trials,
even
terrifying
fact
just
32
for
treating
pathogens.28
Cefiderocol,
probenecid,
durlobactam,
murepavadin,
cestobiprole,
example
antibiotic
effective
pathogens.17
Presently,
vaccines
trial,
likely
available
upcoming
but
meanwhile
help
control
preventive
measures,
reduce
number
active
include
proper
hygiene
practices,
appropriate
sanitation
protective
must
taken
avoid
transmission
strains.
Antimicrobial
should
prescribed
judiciously
unnecessary
length
broad-spectrum
avoided.
awareness
both
physician
patient
regarding
suppress
rise
Both
countries
follow
certain
rules
regulations
prevent
wasteful
marketing.
highly
feed
animals
chicken,
pig,
fish
investigated,
they
directly
develop
humans.
consume
good
healthy
nutrient
vitamin
content
boost
immunity
naturally.
conclusion,
know
therapies
multiple
pipeline.
seen
consequences
take
lessons
prepare
ourselves
nano-particles
based
formulations,
biomaterial
vaccine
technology
alternatives
treat
Additionally,
consuming
combating
AMR.
Sakshi
Painuli:
Conceptualization;
data
curation;
formal
analysis;
software;
validation;
visualization;
writing—original
draft;
writing—review
editing.
Prabhakar
Semwal:
Formal
investigation;
supervision;
Rohit
Sharma:
Data
Shopnil
Akash:
Validation;
authors
declare
conflict
interest.
All
used
support
findings
article.
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(11), P. 5785 - 5798
Published: March 6, 2024
In
the
modern
era,
water
pollution,
especially
from
industries,
agricultural
farms,
and
residential
areas,
is
caused
by
release
of
a
large
scale
heavy
metals,
organic
pollutants,
chemicals,
etc.,
into
environment,
posing
serious
threat
to
aquatic
ecosystems
nature.
Moreover,
untreated
sewage
waste
discharged
directly
nearby
bodies
can
cause
various
diseases
mankind
due
high
load
fecal
coliform
bacteria.
This
work
demonstrates
development
biocompatible,
cost-effective,
highly
robust,
efficient,
flexible,
freestanding,
reusable
membrane
using
naturally
formed
biocompatible
kaolinite
clay-doped
poly(vinylidene
fluoride-hexafluoropropylene)
(PVDF-HFP)
for
effective
piezodynamic
destruction
this
study,
Escherichia
coli
(E.
coli)
Enterococcus
faecalis
faecalis)
have
been
used
evaluate
mechanical
stimulus-responsive
antibacterial
efficacy
nanocomposite
membrane.
The
effectively
eradicate
nearly
99%
viable
E.
97%
within
span
40
min
under
stimulation
(soft
ultrasound
∼15
kHz).
To
further
understand
mechanism,
an
evaluation
reactive
oxygen
species
bacterial
FESEM
was
performed.
These
studies
revealed
that
cells
suffered
severe
visible
cell
damage
after
piezocatalysis,
elucidating
fact
synthesized
capable
producing
superior
effect.
Theranostics,
Journal Year:
2025,
Volume and Issue:
15(9), P. 4147 - 4174
Published: March 15, 2025
Magnetic
resonance
imaging
(MRI)
guidance
in
the
realm
of
anticancer
therapy
is
crucial
to
visualize
spread
tumors
deep
tissues,
accumulate
therapeutics,
and
trigger
them
for
precise
therapy.
Recent
studies
bridge
this
gap
by
integrating
MRI
contrast
agents
(CAs)
with
different
therapeutic
regimes
a
better
outcome.
In
context,
manganese-based
materials
hold
great
potential
owing
their
T1/T2
dual-modal
MR-relaxation,
less
toxicity,
other
capabilities
such
as
chemodynamic
therapy,
immunotherapy,
etc.,
which
have
gained
increasing
interest
among
researchers
medical
professionals.
This
work
offers
timely
update
on
last
three
years
Mn-based
MRI-guided
theranostic
applications,
including
chemotherapy,
photo
therapies,
sonodynamic
radiotherapy
against
cancer.
Further,
several
combinatory
therapies
surgical
intersections
also
been
summarized
light
guidance.
The
design
rationale
these
has
discussed
understand
existing
challenges
plausible
outcomes
shortly.
Herein,
we
dive
into
stimulus-based
probes
pH,
temperature,
etc.
show
unexplored
Mn-complexes
domain.
state-of-the-art
review
will
guide
innovations
CAs
expedite
safer
modules
clinical
translation.
