Copper, Zinc, and Titanium‐Based Semiconductor Nanomaterials for Antimicrobial Coatings and Their Mechanisms DOI Creative Commons
Ravichandran Manisekaran, Aruna‐Devi Rasu Chettiar, Latha Marasamy

et al.

Nano Select, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

ABSTRACT Throughout the course of human civilization, numerous disease outbreaks have caused major impacts by affecting lives mankind. Currently, excessive and improper use antimicrobials has led to emergence drug‐resistant pathogens, making Antimicrobial Resistance (AMR) a critical global threat, as recognized World Health Organization (WHO). If left unaddressed, it will cost approximately USD 100 trillion world economy 2050. Therefore, nanotechnology emerged promising field, offering wide range nanomaterials that can be effectively utilized combat microorganisms. Among these materials, semiconductor (SNMs) attracted significant attention owing their exceptional inherent properties employed. hospital‐acquired infections associated with medical devices pose substantial risks patients. Consequently, researchers explored application SNMs in form antimicrobial coatings or surfaces. This review presents comprehensive recent investigation widely studied SNMs, such titanium, zinc, copper‐based, for coating various surfaces (glass, stainless steel, devices, textiles, polymers) effects. By preventing eradicating microbial growth, potential exert positive impact, viable solution essential industrial

Language: Английский

Bacterial persisters: molecular mechanisms and therapeutic development DOI Creative Commons
Hongxia Niu, Jiaying Gu, Ying Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 17, 2024

Abstract Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing) bacteria that survive in stress environments such as antibiotic exposure, acidic and starvation conditions. These cells can regrow after removal remain the same stress. are underlying problems of treating chronic persistent infections relapse treatment, resistance development, biofilm infections, pose significant challenges for effective treatments. Understanding characteristics exact mechanisms persister formation, especially key molecules affect formation survival persisters is critical more treatment infections. Currently, genes related being discovered confirmed, but by which form very complex, there still many unanswered questions. This article comprehensively summarizes historical background bacterial persisters, details their complex relationship with tolerant resistant bacteria, systematically elucidates interplay between various biological processes cells, well consolidates diverse anti-persister compounds We hope provide theoretical in-depth research on suggest new ideas choosing strategies

Language: Английский

Citations

54
Tannic acid-assisted green functionalization of Clinoptilolite: a step-by-step characterization of silver nanoparticles in situ reduction DOI Creative Commons
Francesca Gattucci, Mari Lallukka,

Nadia Grifasi

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Non‐Covalent Interaction Induced Supramolecular Precipitate with Hetero‐Motif Polyionic Junction for Durable Antimicrobial Activity and Infected Wound Healing DOI Open Access
Xuejiao Wang,

Lianbo He,

Huanling He

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

The advent of the COVID-19 pandemic has underscored pressing demand for antimicrobial materials that offer both durability and efficacy. Herein, successful design fabrication a "water-insoluble" supramolecular precipitate is reported through "bottom-up" assembly polyanion sodium alginate (SA) with motifs A2G Cu2+. This innovative hetero-motif polyionic junction leverages network hydrogen bonds aligning electrostatic interactions, hydrophobic effects to mitigate rapid release active components, providing exceptional long-term efficacy against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Candida albicans (C. albicans). Specifically, it retains an impressive 99.9% S. even after enduring 10 successive wash cycles. hydroxyl groups in A2G-Cu-SA confer adhesion wide array substrates. robust adherence complemented by its antibacterial properties, material maintaining rate being submerged water extended period 100 days. In vivo vitro studies substantiate biocompatibility A2G-Cu-SA, while clinical potential evidenced enhanced healing aureus-infected wounds upon titanium sheet coating. innovation meets current need effective antimicrobials contributes sustainable medical advancements.

Language: Английский

Citations

0
The growing threat of superbugs in pediatric medicine: A narrative review DOI
Aditya Jain,

Revat Meshram,

Shyam Lohiya

et al.

Multidisciplinary Reviews, Journal Year: 2025, Volume and Issue: 8(7), P. 2025211 - 2025211

Published: Feb. 6, 2025

Superbugs, or multidrug-resistant bacteria, represent a growing threat to global health, particularly in paediatric populations. The inappropriate and excessive use of antibiotics exerts selective pressure on bacterial populations, promoting the survival resistant strains while eliminating susceptible ones. Superbugs are dangerous pediatric where infections with bacteria result higher morbidity mortality rates. Misuse over-prescription continue be key contributors emergence strains. Children especially vulnerable due their developing immune systems frequent exposure healthcare-associated infections. This review focuses most common superbugs affecting children, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococcus (VRE), Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, Carbapenem-resistant Enterobacteriaceae (CRE), Pseudomonas aeruginosa (MDRPA). examines recent studies prevalence, clinical impact, treatment challenges posed by these pathogens patients. MRSA continues leading cause skin, soft tissue, bone infections, VRE is increasingly seen nosocomial rise ESBL-producing complicates management urinary tract non-carbapenem treatments like gentamicin nitrofurantoin showing promise. CRE MDRPA critically ill associated high rates limited options. Newer such as daptomycin, linezolid, ceftazidime-avibactam offer potential, but concerns regarding side effects lack paediatric-specific data persist. Effective children requires ongoing surveillance, judicious antibiotics, continued research develop safer more effective therapies. underscores urgent need for research, combat rising

Language: Английский

Citations

0
Virulence traits, agr typing, multidrug resistance patterns, and biofilm ability of MDR Staphylococcus aureus recovered from clinical and subclinical mastitis in dairy cows DOI Creative Commons

Nada Eidaroos,

Abdelazeem M. Algammal,

Walaa I. Mohamaden

et al.

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 19, 2025

Bovine mastitis caused by Staphylococcus aureus is considered a public health threat globally. Herein, we aimed to investigate the occurrence, agr typing, antimicrobial resistance patterns, biofilm production, and PCR-based detection of virulence, biofilm, adhesion, enterotoxins genes S. strains recovered from clinical subclinical bovine mastitis. The prevalence in examined milk samples was 44.4%. Besides, 95% retrieved were identified as MRSA. all tested isolates producers. PCR revealed that 85% positive for I gene. Furthermore, clfB, clfA, fnbB, fnbA, cna detected with 100%, 80%, 60%, 55%, 30%, respectively. Also, coa gene (100%). 92.5% harbored lukF spa genes, In addition, hla, hlb, hlg hemolysin 70%, 50%, 35%, Among enterotoxin seb 30% strains. eno icaA Moreover, 15% MDR 8 agents mecA, ermC, ermB genes. As well, 12.5% carried ermB, tetK, tetM 5% XDR 11 existence MRSA hazard. coa, eno, icaA, lukF, spa, hla virulence are commonly associated predominant milk.

Language: Английский

Citations

0
Structural and Biological Investigation of (E)-2-((2-Butyl-4-Chloro-1H-Imidazol-5-yl)methylene)hydrazine-1-carbothioamide: Synthesis, Structural Insights, Antitubercular Screening, Molecular Docking, DFT, and ADME Studies DOI
Vishnu A. Adole,

A. Ram Kumar,

S. Selvaraj

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142560 - 142560

Published: May 1, 2025

Language: Английский

Citations

0
Antimicrobial Resistance: Techniques to Fight AMR in Bacteria – A Review DOI Creative Commons

Ernessto Mahizhchi,

Diveyaa Sivakumar, Megala Jayaraman

et al.

Journal of Pure and Applied Microbiology, Journal Year: 2024, Volume and Issue: 18(1), P. 16 - 28

Published: March 1, 2024

Antimicrobials or antibiotics were the important revelations of last century, however, it came along with a silent curse that people care less to talk about. Antimicrobial resistance (AMR) which emerged alongside in century has been significant concern for scientists and policymakers. Since their discovery, noted widespread use is primary cause bacteria developing antimicrobial drug resistance. Despite recognition this issue, challenging curtail because they are essential treating various infections. Paradoxically, necessity using these drugs becomes an inadvertent advantage evolve mechanisms. This dilemma creates seeming stalemate our battle against tiny microorganisms. Delaying action could have dire consequences, potentially leading emergence stronger superbugs pose serious threat entire human population. The recent COVID-19 pandemic serves as stark reminder devastating impact small microbe can on global health. paper delves into mechanisms bacteria, evolution innovative techniques employed by combat challenges. Taking proactive steps crucial avoid future where we at mercy increasingly resilient microbes.

Language: Английский

Citations

3
Metagenomics reveals the potential transmission risk of resistomes from urban park environment to human DOI
Xiaochen Wang,

Yuan Qian,

Yu Wang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 477, P. 135387 - 135387

Published: July 31, 2024

Language: Английский

Citations

3
Revolutionizing antibiotic therapy: polymyxin B and Fe2+-enriched liposomal carrier harness novel bacterial ferroptosis mechanism to combat resistant infections DOI Creative Commons

Xiangrong Wei,

Xinhui Cao, Chengyi Xu

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101293 - 101293

Published: April 1, 2025

Language: Английский

Citations

0
Characterization of ES10 lytic bacteriophage isolated from hospital waste against multidrug-resistant uropathogenic E. coli DOI Creative Commons

Aneela Nawaz,

Sabeena Zafar,

Abdulrahman H. Alessa

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Escherichia coli is the major causative agent of urinary tract infections worldwide and emergence multi-drug resistant determinants among clinical isolates necessitates development novel therapeutic agents. Lytic bacteriophages efficiently kill specific bacteria seems promising approach in controlling caused by pathogens. This study aimed isolation detailed characterization lytic bacteriophage designated as ES10 capable lysing multidrug-resistant uropathogenic E. . had icosahedral head non-contractile tail genome size was 48,315 base pairs long encoding 74 proteins. Antibiotics resistance, virulence lysogenic cycle associated genes were not found phage genome. Morphological whole analysis showed that member Drexlerviridae Latent time 30 min, burst 90, optimal multiplicity infection 1. stable human blood subsequently 99.34% reduction host bacteria. Calcium chloride shortened adsorption latency period significantly inhibited biofilm formation 99.84% from contaminated fomites. possesses potential to be utilized standard therapy.

Language: Английский

Citations

3