[12]aneN3-modified camptothecin and PEGylated AIEgens co-assembly into core–shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy DOI

Xueyi Sun,

Yaxuan Liang,

Yi-Nan Gao

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(37), P. 8943 - 8955

Published: Jan. 1, 2023

A novel dual-responsive nanoparticle (NP) system was aimed to be developed for the co-delivery of camptothecin (CPT) and plasmid encoding TNF-related apoptosis-inducing ligand (pTRAIL) DNA in cancer therapy. The combination prodrug CPT nucleic acid condensing di-(triazole-[12]aneN3) unit with 4-nitrobenzyl ester through alkyl chains resulted three nitroreductase (NTR) responsive amphiphiles, CNN1-CNN3 (with 5, 8, 11 carbon chains, respectively). Among them, CNN2 most effective inhibiting proliferation HeLa cells presence fusogenic lipid DOPE. NPs composed CNN2, pDNA, DOPE were further co-assembled ROS-responsive thioketal-linked amphiphilic polymer (TTP) afford core-shell (CNN2-DT/pDNA) an average size 118 nm, which exhibited high drug-loading capacity, excellent serum tolerance, good biocompatibility. In ROS, NTR, NADH, decomposed, leading efficient release 80% abundant pDNA. self-assembly delivery process CNN2-DT clearly observed AIE fluorescent imaging. vitro vivo results demonstrated that CNN2-DT/pTRAIL synergistically promoted 68% apoptosis tumor inhibited growth negligible toxic side effects. This study showed provide a spatially temporally-controlled strategy

Language: Английский

Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy DOI

Zongyan He,

Jun Du, Yuqing Miao

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(22)

Published: April 18, 2023

As a noninvasive treatment, sonodynamic therapy (SDT) has been widely used in the treatment of tumors because its ability to penetrate deep tissue with few side effects. key factor SDT, it is meaningful design and synthesize efficient sonosensitizers. Compared organic sonosensitizers, inorganic sonosensitizers can be easily excited by ultrasound. In addition, stable properties, good dispersion, long blood circulation time, have great development potential SDT. This review summarizes possible mechanisms SDT (sonoexcitation ultrasonic cavitation) detail. Based on these mechanisms, synthesis nanosonosensitizers divided into three categories: traditional semiconductor enhanced cavitation-enhanced Subsequently, current construction methods are summarized including accelerated charge separation production reactive oxygen species through cavitation. Furthermore, advantages disadvantages different detailed strategies systematically discussed how enhance Hopefully, this could provide new insights nano-sonosensitizers for

Language: Английский

Citations

55
Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy DOI Open Access
Ziyin Chen, Ziqi Yue,

Kaiqi Yang

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(26)

Published: Aug. 4, 2023

Abstract The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, have found significant role improving drug delivery inhibiting the growth metastasis tumor cells. Moreover, recent studies highlighted potential modulating microenvironment (TME) enhancing activity immune cells improve therapy efficacy. Various types are currently utilized carriers, immunosuppressants, activators, immunoassay reagents, more for immunotherapy. Necessarily, used immunotherapy can be grouped into two categories: organic inorganic nanomaterials. Though both shown ability achieve purpose immunotherapy, composition properties result differences mechanisms modes action. Organic further divided polymers, cell membranes, nanoemulsion‐modified, hydrogel forms. At same time, broadly classified nonmetallic metallic current work aims explore action these different prospects promoting

Language: Английский

Citations

31
Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy DOI Creative Commons
Yue Li, Jia Chen, Qi Xia

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 16, 2024

Photothermal therapy (PTT) is a promising non-invasive treatment that has shown great potential in eliminating tumors. It not only induces apoptosis of cancer cells but also triggers immunogenic cell death (ICD) which could activate the immune system against cancer. However, immunosuppressive tumor microenvironment (TIME) poses challenge to triggering strong responses with single treatment, thus limiting therapeutic effect immunotherapy. In this study, dual-targeted nano delivery (GOx@FeNPs) combined αPD-L1 checkpoint blocker inhibit colorectal (CRC) progression by mediating PTT, ferroptosis and anti-tumor response. Briefly, specific was achieved cyclic arginine glycyl aspartate (cRGD) peptide anisamide (AA) GOx@FeNPs had good photothermal realize PTT induce ICD, deplete glutathione (GSH) catalyze production reactive oxygen species (ROS) from endogenous H

Language: Английский

Citations

13
A pH-responsive ZC-QPP hydrogel for synergistic antibacterial and antioxidant treatment to enhance wound healing DOI

Ziwen Zhang,

Jinxia Wang,

Yu Luo

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(38), P. 9300 - 9310

Published: Jan. 1, 2023

The problems of bacterial resistance and high oxidation level severely limit wound healing. Therefore, we constructed a multifunctional platform chitosan quaternary ammonium salts (QCS)/polyvinyl alcohol (PVA)/polyethylene glycol (PEG) hydrogels (QPP) loaded with ZnO@CeO2 (ZC-QPP). Firstly, the hydrogel was co-cross-linked by hydrogen borate ester bonds, which allows easy adherence to tissue surface for offering protective barrier moist environment wounds. due their amino groups have inherent antibacterial properties induce death. In response acidic conditions infection microenvironment, bonds in QPP break ZC NCs dispersed are released. gradual dissociation Zn2+ under can directly damage membranes. site always causes overexpression reactive oxygen species (ROS) levels, often leading inflammation preventing rapid repair. CeO2 eliminate excess ROS reduce inflammatory response. From vitro vivo results, biosafety ZC-QPP has demonstrated excellent antioxidant performance enhance opens method develop synergistic therapeutic platforms combining enzyme-like nanomaterials treatment promote

Language: Английский

Citations

15
Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine DOI Open Access
Ahammed H.M. Mohammed-Sadhakathullah, Sofia Paulo‐Mirasol, Juan Torras

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10312 - 10312

Published: June 18, 2023

Bioresorbable nanomembranes (NMs) and nanoparticles (NPs) are powerful polymeric materials playing an important role in biomedicine, as they can effectively reduce infections inflammatory clinical patient conditions due to their high biocompatibility, ability physically interact with biomolecules, large surface area, low toxicity. In this review, the most common bioabsorbable such those belonging natural polymers proteins for manufacture of NMs NPs reviewed. addition biocompatibility bioresorption, current methodology on functionalization is also revisited recent applications highlighted. Considering use field biosensors, tethered lipid bilayers, drug delivery, wound dressing, skin regeneration, targeted chemotherapy imaging/diagnostics, functionalized have become one main pillars modern biomedical applications.

Language: Английский

Citations

12
Cu(II)-doped mesoporous polydopamine as biodegradable nanoplatforms for photothermal-enhanced multi-mode anti-tumor therapy DOI
Ziwei Yan, Hui Zhang, Jinghao Chen

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 685, P. 133258 - 133258

Published: Jan. 17, 2024

Language: Английский

Citations

4
Functionalizing tetrahedral framework nucleic acids-based nanostructures for tumor in situ imaging and treatment DOI
Minghui Hu, Yingyu Zhang, Mengxin Zhang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 240, P. 113982 - 113982

Published: May 21, 2024

Language: Английский

Citations

4
Nano-Based Strategies Aiming at Tumor Microenvironment for Improved Cancer Therapy DOI
Tianhui Liu,

Changshun Lu,

Xue Jiang

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy chemotherapy, often lack specificity, leading collateral damage normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, elevated ATP levels factors that collectively promote tumor growth metastasis. This review provides comprehensive overview of the nanoparticles developed in recent years for TME-responsive strategies or TME-modulating methods therapy. The focus on designing synthesizing can interact with achieve precisely controlled drug release. These activate release under specific conditions within environment, thereby enhancing efficacy drugs while reducing toxicity cells. Moreover, simply eliminating cells does not fundamentally solve problem. Only comprehensively regulating TME make it unsuitable cell survival proliferation we more thorough therapeutic effects reduce risk recurrence. regulation aim suppress metastasis modulating various components TME. only improve treatment outcomes but also have potential lay foundation future personalized cancer therapies.

Language: Английский

Citations

0
Recent advances in smart biomaterials based on ultrasonic effects DOI
Jie Chen, Qing Zhao, Xiaoqian Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160524 - 160524

Published: Feb. 1, 2025

Language: Английский

Citations

0
Tumor Microenvironment-Responsive Nanodrug for Embolotherapy and Enhanced Chemotherapy DOI

Jialiang Zheng,

Zhenhang Lin,

Xi Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Embolotherapy is an effective antitumor method, which essentially blocks the oxygen supply and induces hypoxia to treat tumors; however, traditional practices demand high expertise harbor risks of complications. This study presents a mesoporous polydopamine-based (MPDA) drug delivery platform modified by engineered fusion proteins, can specifically embolize tumor blood vessels deliver hypoxia-activated prodrug tirapazamine (TPZ). The protein consists affibody targeting HER-2, substrate for MMP-2, RGD tripeptide, truncated tissue factor (tTF), then connected MPDA loaded with TPZ. nanodrug actively target interact MMP-2 in microenvironment (TME), vessels; then, under TME acidic circumstances, releases TPZ, activated aggravated embolization, kills tumors. embolization strategy, only specific conditions, extremely safe, it compensates inadequacies conventional therapy, while also addressing issue deficiency therapy.

Language: Английский

Citations

0