BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 5, 2024
Language: Английский
Journal of Materials Research and Technology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
2
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 208, P. 115292 - 115292
Published: March 24, 2024
Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious and saves millions lives every year. Vaccine design development remains critical involves many aspects, including choice platform, antigen, adjuvant, route administration. Topical vaccination, defined herein as introduction a vaccine any three layers human skin, has attracted interest recent years an alternative vaccination approach conventional intramuscular administration because its potential be needle-free induce superior immune response against pathogens. In this review, we describe progress developing topical vaccines, highlight delivery technologies for discuss factors that might impact efficacy, provide overview current clinical landscape vaccines.
Language: Английский
Citations
8
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2272 - 2272
Published: Sept. 3, 2023
Information on the penetration depth, pathways, metabolization, storage of vehicles, active pharmaceutical ingredients (APIs), and functional cosmetic (FCIs) topically applied formulations or contaminants (substances) in skin is great importance for understanding their interaction with targets, treatment efficacy, risk assessment—a challenging task dermatology, cosmetology, pharmacy. Non-invasive methods qualitative quantitative visualization substances vivo are favored limited to optical imaging spectroscopic such as fluorescence/reflectance confocal laser scanning microscopy (CLSM); two-photon tomography (2PT) combined autofluorescence (2PT-AF), fluorescence lifetime (2PT-FLIM), second-harmonic generation (SHG), coherent anti-Stokes Raman scattering (CARS), reflectance (2PT-RCM); three-photon (3PT); micro-spectroscopy (CRM); surface-enhanced (SERS) micro-spectroscopy; stimulated (SRS) microscopy; coherence (OCT). This review summarizes state art use CLSM, 2PT, 3PT, CRM, SERS, SRS, OCT study non-invasively (302 references). The advantages, limitations, possibilities, prospects reviewed comprehensively discussed. ex studies discussed potentially translatable into measurements. requirements properties determine by certain highlighted.
Language: Английский
Citations
14
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(13), P. 3431 - 3445
Published: Jan. 1, 2024
Encapsulation of 2-aminothiophenes in calcium carbonate particles leads to improved antitumor activity against melanoma.
Language: Английский
Citations
5
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2574 - 2574
Published: Nov. 2, 2023
The widespread application of calcium carbonate is determined by its high availability in nature and simplicity synthesis laboratory conditions. Moreover, possesses highly attractive physicochemical properties that make it suitable for a wide range biomedical applications. This review provides conclusive analysis the results on using tunable vaterite metastability development biodegradable drug delivery systems therapeutic vehicles with controlled sustained release incorporated cargo. manuscript highlights nuances recrystallization to non-porous calcite, dissolution at acidic pH, biodegradation vivo conditions control over these processes. outlines main benefits instability liberation encapsulated molecules natural synthetic polymeric materials purposes.
Language: Английский
Citations
11
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 115477 - 115477
Published: Nov. 1, 2024
Language: Английский
Citations
3
Micromachines, Journal Year: 2023, Volume and Issue: 15(1), P. 16 - 16
Published: Dec. 21, 2023
The development of advanced methods for the synthesis nano- and microparticles in field biomedicine is high interest due to a range reasons. current may have limitations terms efficiency, scalability, uniformity particles. Here, we investigate submicron calcium carbonate using microfluidic chip with T-shaped oil supply droplet-based facilitate control over formation design allowed precise manipulation reaction parameters, resulting improved porosity while maintaining an efficient rate. pore size distribution within particles was estimated via small-angle X-ray scattering. This study showed that reduced facilitated higher loading model peptide: 16 vs. 9 mass.% synthesized device bulk, correspondingly. biosafety developed concentration 0.08–0.8 mg per plate established by results cytotoxicity mouse fibroblasts. innovative approach microfluidically assisted provides promising avenue future research particle drug delivery systems.
Language: Английский
Citations
7
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(20), P. 4867 - 4881
Published: Jan. 1, 2024
Inflammatory dermatoses represent a global problem with increasing prevalence and recurrence among the world population. Topical glucocorticoids (GCs) are most commonly used anti-inflammatory drugs in dermatology due to wide range of their therapeutic actions, which, however, have numerous local systemic side effects. Hence, there is growing need create new delivery systems for GCs, ensuring drug localization pathological site, thus effectiveness therapy lowering risk Here, we propose novel topical particulate formulation GC clobetasol propionate (CP), based on use porous calcium carbonate (CaCO3) carriers vaterite crystalline form. The designed contain substantially higher CP amount than conventional dosage forms clinics (4.5% w/w vs. 0.05% w/w) displayed good biocompatibility effective cellular uptake when studied fibroblasts vitro. Hair follicles an important reservoir accumulation skin house targets its action. In this study, demonstrated successful CP-loaded (CP-CaCO3) into hair rats vivo using optical coherent tomography (OCT). Importantly, OCT monitoring revealed gradual intrafollicular degradation within 168 h abundant follicle filling occurring first 48 h. Biodegradability makes proposed system especially promising searching formulations improved safety release profile. Our findings evidenced great potential CaCO3 improving dermal bioavailability poorly water-soluble GC.
Language: Английский
Citations
2
Published: Jan. 1, 2024
Composite materials composed of porous vaterite (CaCO3) microcrystals, loaded with functional inorganic nanoparticles, are actively being investigated for various practical applications. More recently, a freezing-induced loading technique has been demonstrated as versatile and efficient method preparing composites microparticles based on vaterite. However, despite its high effectiveness, the impact nanoparticle concentration process structural properties resulting have not previously studied. In this study, first time, we evaluated applicability conventional adsorption models to describe citrate-coated silver nanoparticles (AgNPs).The fitting dependence capacity crystals residual AgNP two- or three-parameter revealed that best fit was achieved Freundlich model (R² = 0.969), suggesting non-uniform deposition interparticle aggregation (Freundlich n > 1). This confirmed by electron microscopy elemental analysis, which formation growth Ag aggregates CaCO3 surface increasing initial concentration. Overall, these findings valuable in enhancing our understanding optimizing preparation
Language: Английский
Citations
0
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 700, P. 134815 - 134815
Published: July 14, 2024
Language: Английский
Citations
0