Uranium Exposure and Kidney Tubule Biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA)

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121060 - 121060

Published: Feb. 1, 2025

Language: Английский

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Association of Urinary Metals With Cardiovascular Disease Incidence and All-Cause Mortality in the Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation, Journal Year: 2024, Volume and Issue: 150(10), P. 758 - 769

Published: Aug. 1, 2024

BACKGROUND: Exposure to metals has been associated with cardiovascular disease (CVD) end points and mortality, yet prospective evidence is limited beyond arsenic, cadmium, lead. In this study, we assessed the association of urinary incident CVD all-cause mortality in a racially diverse population US adults from MESA (the Multi-Ethnic Study Atherosclerosis). METHODS: We included 6599 participants (mean [SD] age, 62.1 [10.2] years; 53% female) available at baseline (2000 2001) followed through December 2019. used Cox proportional hazards models estimate adjusted hazard ratio 95% CI by levels tungsten, uranium (nonessential metals), cobalt, copper, zinc (essential metals). The joint 6 as mixture corresponding 10-year survival probability was calculated using Elastic-Net. RESULTS: During follow-up, 1162 developed CVD, 1844 died. behavioral clinical indicators, ratios (95% CI) for comparing highest lowest quartile were, respectively: 1.25 (1.03, 1.53) 1.68 (1.43, 1.96) cadmium; 1.20 (1.01, 1.42) 1.16 1.33) tungsten; 1.32 (1.08, 1.62) (1.12, 1.56) uranium; 1.24 1.48) 1.37 (1.19, 1.58) cobalt; 1.42 (1.18, 1.70) 1.50 (1.29, 1.74) copper; 1.21 1.45) 1.38 (1.20, 1.59) zinc. A positive linear dose-response identified cadmium copper both points. an interquartile range (IQR) increase these difference were 1.29 (1.11, –1.1% (–2.0, –0.05) 1.66 (1.47, 1.91) –2.0% (–2.6, –1.5) mortality. CONCLUSIONS: This epidemiological study indicates that metal are increased risk These findings can inform development novel preventive strategies improve health.

Language: Английский

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Tampons as a source of exposure to metal(loid)s

Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108849 - 108849

Published: June 22, 2024

Between 52-86% of people who menstruate in the United States use tampons-cotton and/or rayon/viscose 'plugs'-to absorb menstrual blood vagina. Tampons may contain metals from agricultural or manufacturing processes, which could be absorbed by vagina's highly absorptive tissue, resulting systemic exposure. To our knowledge, no previous studies have measured tampons.

Language: Английский

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Urinary Metal Levels and Coronary Artery Calcification

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(16), P. 1545 - 1557

Published: Sept. 18, 2024

Exposure to metals, a newly recognized risk factor for cardiovascular disease (CVD), could be related atherosclerosis progression.

Language: Английский

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Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Journal of Analytical Atomic Spectrometry, Journal Year: 2025, Volume and Issue: 40(3), P. 541 - 664

Published: Jan. 1, 2025

This review discusses developments in elemental mass spectrometry, atomic absorption, emission and fluorescence, XRF LIBS, as applied to the analysis of specimens clinical interest, foods beverages. Sample preparation procedures quality assurance are also included.

Language: Английский

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Urinary Metal Levels and Coronary Artery Calcification

Journal of the American College of Cardiology, Journal Year: 2025, Volume and Issue: 85(10), P. e107 - e107

Published: March 1, 2025

Language: Английский

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Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(12), P. e2448286 - e2448286

Published: Dec. 2, 2024

Importance Metals are established neurotoxicants, but evidence of their association with cognitive performance at low chronic exposure levels is limited. Objective To investigate the urinary metal levels, individually and as a mixture, tests dementia diagnosis, including effect modification by apolipoprotein ε4 allele ( APOE 4). Design, Setting, Participants The multicenter prospective cohort Multi-Ethnic Study Atherosclerosis (MESA) was started from July 2000 to August 2002, follow-up through 2018. A total 6303 MESA participants were included. Data analysis performed October 12, 2023, June 13, 2024. Exposure Urine samples collected baseline (2000-2002), arsenic, cadmium, cobalt, copper, lead, manganese, tungsten, uranium, zinc measured in 2020-2022. Main Outcomes Measures Digit Symbol Coding (DSC) (n = 3819) (possible score range, 0-133), Cognitive Abilities Screening Instrument (CASI) 3918) 0-100), Span (DS) 4176) 0-30) administered 2010-2012; higher scores each test indicate increasing positive response. Results followed up for diagnosis median age 60 (IQR, 53-70) years, 3303 (52.4%) female. 51 38-64) DSC, 90 84-95) CASI, 15 12-18) DS. There 559 cases period. Inverse associations DSC identified: mean differences z per IQR increase −0.03 (95% CI, −0.07 0.00) −0.05 −0.09 −0.004) −0.02) −0.04 −0.08 −0.001) −0.06 −0.01) zinc. Among 1058 4 carriers, manganese also inversely associated DSC. joint difference comparing percentile 95th 25th 9-metal mixture −0.30 −0.47 −0.14) APOE4 carriers −0.10 −0.19 noncarriers. Arsenic, dementia, hazard ratios ranging 1.15 1.03-1.29) tungsten 1.46 1.06-2.02) uranium. ratio percentiles 1.71 1.24-3.89), no significant status. Conclusions Relevance In this study, concentrations metals urine, compared those lower concentrations, had worse on greater likelihood developing dementia. findings multiethnic study might inform screening potential interventions prevention based individuals’ genetic profiles.

Language: Английский

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Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis (MESA)

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 1, 2023

Growing evidence indicates that exposure to metals are risk factors for cardiovascular disease (CVD). We hypothesized higher urinary levels of with prior an association CVD, including non-essential (cadmium , tungsten, and uranium) essential (cobalt, copper, zinc) associated baseline rate change coronary artery calcium (CAC) progression, a subclinical marker atherosclerotic CVD.

Language: Английский

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Arsenic Speciation Analysis in Human Urine for Long Term Epidemiological Study Setups: The Multi-Ethnic Study of Atherosclerosis (Mesa)

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

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Arsenic speciation analysis in human urine for long term epidemiological studies: The Multi-Ethnic Study of Atherosclerosis (MESA)

Environmental Research, Journal Year: 2024, Volume and Issue: 262, P. 119833 - 119833

Published: Aug. 22, 2024

Language: Английский

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