Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development DOI Creative Commons

Linnea Tscheuschner,

Abraham R. Tzafriri

Bioengineering, Journal Year: 2023, Volume and Issue: 10(12), P. 1373 - 1373

Published: Nov. 29, 2023

In the early years of tissue engineering, scientists focused on generation healthy-like tissues and organs to replace diseased areas with aim filling gap between organ demands actual donations. Over time, realization has set in that there is an additional large unmet need for suitable disease models study their progression test refine different treatment approaches. Increasingly, researchers have turned engineering address this controllable translational models. We review existing potential uses tissue-engineered cardiovascular research suggest guidelines generating adequate models, aimed both at studying mechanisms supporting development dedicated drug-delivery therapies. This involves discussion requirements drugs, nanoparticles, drug-eluting devices. addition realistic cellular composition, mechanical structural properties are needed simulate pathological reality addressed.

Language: Английский

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering DOI Creative Commons
Tomasz Górnicki, Jakub Lambrinow, Afsaneh Golkar‐Narenji

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(6), P. 531 - 531

Published: March 16, 2024

Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D structures based the presence scaffolding. Scaffold-free consist spheroid technologies. Meanwhile, scaffold contain organoids all constructs that various types scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels one extensively studied forms potential culture up 4D bioprinted biomaterials. bioprinting is important create scaffolds. versatility this allows many different inks, mainly hydrogels, as well inorganic substances. Increasing amounts data evidence vast usage engineering personalized medicine, with area application being regeneration skin musculoskeletal systems. Recent papers also indicate increasing vivo tests products which further strengthen importance branch emphasize need extensive research safe humansbiomimetic tissues organs. In review article, we recent advancements field preceded by an overview technologies led development complex type culture.

Language: Английский

Citations

20
Smart biomaterials in healthcare: Breakthroughs in tissue engineering, immunomodulation, patient-specific therapies, and biosensor applications DOI Creative Commons
Ansheed Raheem, Kalpana Mandal, Swarup Biswas

et al.

Applied Physics Reviews, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 1, 2025

Smart biomaterials have significantly impacted human healthcare by advancing the development of medical devices designed to function within tissue, mimicking behavior natural tissues. While intelligence has evolved from inert active over past few decades, smart take this a step further making their surfaces or bulk respond based on interactions with surrounding tissues, imparting outcomes similar tissue functions. This interaction helps in creating stimuli-responsive biomaterials, which can be useful engineering, regenerative medicine, autonomous drug delivery, orthopedics, and much more. Traditionally, material engineering focused refining static properties accommodate them body without evoking an immune response, was major obstacle unrestricted operation. review highlights explains various approaches currently under research for developing that tune responses bodily factors like temperature, pH, ion concentration external magnetism, light, conductivity. Applications soft hard 4D printing, scaffold design are also discussed. The advanced application microfluidics, organ-on-a-chip models, extensively benefits intrinsic discussed below. elaborates how biomaterial could revolutionize biosensor applications, thereby improving patient care quality. We delineate limitations key challenges associated providing insights into path forward outlining future directions next-generation will facilitate clinical translation.

Language: Английский

Citations

1
Unveiling the potential of biomaterials and their synergistic fusion in tissue engineering DOI Creative Commons
Eva Sanchez Armengol, Nathalie Hock,

Sila Saribal

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 196, P. 106761 - 106761

Published: April 3, 2024

Inspired by nature, tissue engineering aims to employ intricate mechanisms for advanced clinical interventions, unlocking inherent biological potential and propelling medical breakthroughs. Therefore, medical, pharmaceutical fields are growing interest in organ replacement, repair, regeneration this technology. Three primary currently used engineering: transplantation of cells (I), injection growth factors (II) cellular seeding scaffolds (III). However, develop presenting highest potential, reinforcement with polymeric materials is interest. For instance, natural synthetic polymers can be used. Regardless, chitosan keratin two biopolymers great biocompatibility, biodegradability non-antigenic properties purposes offering restoration revitalization. combination has been studied results exhibit highly porous providing optimal environment cultivation. This review give an historical as well current overview engineering, involved the field.

Language: Английский

Citations

8
Injectable Hydrogels in Cardiovascular Tissue Engineering DOI Open Access
Raj N. Patel, Dhruvi Patel

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1878 - 1878

Published: July 1, 2024

Heart problems are quite prevalent worldwide. Cardiomyocytes and stem cells two examples of the supporting matrix that used in integrated process cardiac tissue regeneration. The objective is to create innovative materials can effectively replace or repair damaged muscle. One most effective appealing 3D/4D scaffolds for creating an appropriate milieu growth healing hydrogel. In order successfully regenerate heart tissue, bioactive biocompatible hydrogels required preserve infarcted region bid support restoration myocardial wall stress, cell survival function. engineering uses a variety hydrogels, such as natural synthetic polymeric hydrogels. This article provides quick overview various hydrogel types employed engineering. Their benefits drawbacks discussed. Hydrogel-based techniques regeneration also addressed, along with their clinical application future

Language: Английский

Citations

6
3D bioprinted tumor model: a prompt and convenient platform for overcoming immunotherapy resistance by recapitulating the tumor microenvironment DOI Creative Commons

Zhanyi Zhang,

Xuebo Chen,

Sujie Gao

et al.

Cellular Oncology, Journal Year: 2024, Volume and Issue: 47(4), P. 1113 - 1126

Published: March 23, 2024

Cancer immunotherapy is receiving worldwide attention for its induction of an anti-tumor response. However, it has had limited efficacy in some patients who acquired resistance. The dynamic and sophisticated complexity the tumor microenvironment (TME) leading contributor to this clinical dilemma. Through recapitulating physiological features TME, 3D bioprinting a promising research tool cancer immunotherapy, which preserves vivo malignant aggressiveness, heterogeneity, cell-cell/matrix interactions. It been reported that application holds potential address challenges resistance facilitate personalized medication.

Language: Английский

Citations

5
Bioprinting: Mechanical Stabilization and Reinforcement Strategies in Regenerative Medicine DOI

Ashleigh Ballard,

Rebecca Patush,

Jenesis Perez

et al.

Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: 30(13-14), P. 387 - 408

Published: Jan. 11, 2024

Bioprinting describes the printing of biomaterials and cell-laden or cell-free hydrogels with various combinations embedded bioactive molecules. It encompasses precise patterning cells to create scaffolds for different biomedical needs. There are many requirements that bioprinting face, it is ultimately interplay between scaffold's structure, properties, processing, performance will lead its successful translation. Among essential properties must possess—adequate appropriate application-specific chemical, mechanical, biological performance—the mechanical behavior hydrogel-based bioprinted key their stable in vivo at site implantation. Hydrogels typically constitute main scaffold material medium biomolecules very soft, often lack sufficient stability, which reduces printability and, therefore, potential. The aim this review article highlight reinforcement strategies used approaches achieve enhanced stability bioinks printed scaffolds. Enabling robust materials processes creation truly complex remarkable structures could accelerate application smart, functional settings. a powerful tool fabrication 3D applications. has gained tremendous attention recent years, bioink library expanding include more combinations. From practical perspective, need be considered, such as structure's performances. these, constructs critical translation into clinic. explore stabilization structures.

Language: Английский

Citations

4
3D printed therapeutic scaffolds for wound healing applications DOI
Sofía Municoy, Pablo Edmundo Antezana,

Sofía Genovés

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 207 - 226

Published: Jan. 1, 2025

Language: Английский

Citations

0
4D printing polymeric biomaterials for adaptive tissue regeneration DOI
Zhe Wang, Duo Ma, Juan Liu

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 370 - 399

Published: Feb. 22, 2025

Language: Английский

Citations

0
4D Bioprinting for Personalized Medicine, Innovations in Implant Fabrication and Regenerative Therapies DOI

Senthil Maharaj Kennedy,

Manigandan Sekar,

A. Vasanthanathan

et al.

Polymer-Plastics Technology and Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: March 30, 2025

Language: Английский

Citations

0
Cardiovascular Computed Tomography in the Diagnosis of Cardiovascular Disease: Beyond Lumen Assessment DOI Creative Commons
Zhonghua Sun,

Jenna Silberstein,

Mauro Vaccarezza

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(1), P. 22 - 22

Published: Jan. 12, 2024

Cardiovascular CT is being widely used in the diagnosis of cardiovascular disease due to rapid technological advancements scanning techniques. These include development multi-slice CT, from early generation latest models, which has capability acquiring images with high spatial and temporal resolution. The recent emergence photon-counting further enhanced performance clinical applications, providing improved contrast CT-derived fractional flow reserve superior standard CT-based anatomical assessment for detection lesion-specific myocardial ischemia. 3D-printed patient-specific models are also offering advantages terms educational value, surgical planning, simulation treatment, as well enhancing doctor-patient communication. Three-dimensional visualization tools including virtual reality, augmented mixed reality advancing value disease. With widespread use artificial intelligence, machine learning, deep learning disease, diagnostic significantly improved, promising results presented both prediction. This review article provides an overview applications covering its perspective based on traditional lumen identification vulnerable lesions prediction outcomes these advanced technologies. limitations future prospects technologies discussed.

Language: Английский

Citations

3