Afterglow bio-applications by utilizing triplet excited states of organic materials

Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(11), P. 2930 - 2940

Published: Oct. 23, 2023

Language: Английский

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Reactive Oxygen Species (ROS)-Mediated Antibacterial Oxidative Therapies: Available Methods to Generate ROS and a Novel Option Proposal

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7182 - 7182

Published: June 29, 2024

The increasing emergence of multidrug-resistant (MDR) pathogens causes difficult-to-treat infections with long-term hospitalizations and a high incidence death, thus representing global public health problem. To manage MDR bacteria bugs, new antimicrobial strategies are necessary, their introduction in practice is daily challenge for scientists the field. An extensively studied approach to treating consists inducing levels reactive oxygen species (ROS) by several methods. Although further clinical investigations mandatory on possible toxic effects ROS mammalian cells, evaluations extremely promising, topical use treat infected wounds ulcers, also presence biofilm, already clinically approved. Biochar (BC) carbonaceous material obtained pyrolysis different vegetable animal biomass feedstocks at 200–1000 °C limited O2. Recently, it has been demonstrated that BC’s capability removing organic inorganic xenobiotics mainly due persistent free radicals (PFRs), which can activate oxygen, H2O2, or persulfate absence transition metals electron transfer, generating ROS, turn degrade pollutants advanced oxidation processes (AOPs). In this context, antibacterial BC-containing PFRs have some authors against Escherichia coli Staphylococcus aureus, giving birth our idea BC-derived as novel method capable generation oxidative therapy. Here, general aspects concerning physiological pathological production regulation mechanism they could exert reviewed. methods currently adopted induce therapy discussed. Finally, first time, BC-related proposed source via AOPs.

Language: Английский

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Biopolymer-based hydrogels for biomedical applications: Bioactivity and wound healing properties

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216093 - 216093

Published: July 25, 2024

Language: Английский

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Synergistic effects of nano curcumin mediated photodynamic inactivation and nano-silver@colistin against Pseudomonas aeruginosa biofilms

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 45, P. 103971 - 103971

Published: Jan. 11, 2024

: Patients with burn injuries colonized by multidrug-resistant P. aeruginosa face increased mortality risk. The efficacy of colistin, a last-resort treatment, is declining as resistance levels rise. aeruginosa's robust biofilm exacerbates antibiotic resistance. Photodynamic Inactivation (PDI) shows promise in fighting biofilm. Nano curcumin (nCur) particles were synthesized, and their chemical characteristics determined using zeta potential (ZP), dynamic light scattering analysis (DLS), Fourier transform infrared (FTIR). We conducted an MTT assay to assess the cytotoxicity nCur-mediated PDI combination nanosilver colistin. fractional inhibitory concentration (FBIC) two clinical isolates ATCC 27853 during PDI@AgNPs@CL was 3-dimensional (3-D) checkerboard assay. To study effect on lasI, lasR, rhlI, rhlR, pelA, pslA gene expression, Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) at each isolate's FBIC. impact treatments also investigated scanning electron microscopy (SEM). ZP mean DLS values nCur 10.3 mV 402.6 ±24.6 nm, respectively. distinct functional groups corresponded peaks IR absorption. Cell viability percentages FBIC concentrations Nos. 30, 354, 91.36%, 83.20%, 92.48%, treatment showed synergistic effects 3-D All six genes down-regulation after treatment. most suppressed rhlR (-11.9-fold) 27853. SEM micrographs further proved connecting cement reduction mass mitigation following treatments. combined AgNPs@CL synergistically reduce formation aeruginosa. This may be attributable suppression responsible for regulating production biofilms.

Language: Английский

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The halogen effect of bis-truxene substituted BODIPY photosensitizers for potential photodynamic therapy

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 224, P. 111996 - 111996

Published: Jan. 28, 2024

Language: Английский

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Nitroreductase-responsive nanoparticles for in situ fluorescence imaging and synergistic antibacterial therapy of bacterial keratitis

Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122565 - 122565

Published: April 3, 2024

Language: Английский

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Charge Regulation-Enhanced Type I Photosensitizer-Loaded Hydrogel Dressing for Hypoxic Bacterial Inhibition and Biofilm Elimination

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Biofilm-induced chronic bacterial infections represent a significant challenge in modern medicine due to their resistance conventional antibiotic treatments. Although photodynamic therapy (PDT) has emerged as promising antibiotic-free antibacterial strategy, the hypoxic condition within biofilms and lack of an effective local drug delivery system have limited clinical effectiveness photosensitizer (PS) agents. Herein, we propose type charge regulation-enhanced I PS-loaded hydrogel dressing for treating biofilm infection. The regulation enables multiple alkylation Nile blue (EB series) exhibit substantially improved absorbance (∼2-fold), alkaline tolerance, superoxide anion yield (2.2-4.2-fold) compared representative PS, sulfur-substituted blue. Specifically, enhanced electronic push-pull capabilities promote more efficient electron recycling process, significantly boosting efficiency PDT. superior PDT effect uptake via render EB series pronounced inhibition under red light or sunlight irradiation. Moreover, hydrogel, constructed from oxidized dextran quaternized chitosan, facilitates localization sustained retention PSs, accelerating healing biofilm-infected wounds. This PS-based could provide user-friendly wound treatment prevention infections.

Language: Английский

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Photodynamic therapy alone or in combination to counteract bacterial infections

Expert Opinion on Therapeutic Patents, Journal Year: 2024, Volume and Issue: 34(6), P. 401 - 414

Published: March 5, 2024

Introduction Antibacterial photodynamic therapy presents a promising alternative to antibiotics, with potential against multidrug-resistant bacteria, offering broad-spectrum action, reduced resistance risk, and improved tissue selectivity.

Language: Английский

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Peptide-mimicking poly(2-oxazoline)s as adjuvants to enhance activities and antibacterial spectrum of polymyxin B

Science China Materials, Journal Year: 2024, Volume and Issue: 67(3), P. 991 - 999

Published: Jan. 23, 2024

Language: Английский

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On the Possibility of Using 5-Aminolevulinic Acid in the Light-Induced Destruction of Microorganisms

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3590 - 3590

Published: March 22, 2024

Antimicrobial photodynamic inactivation (aPDI) is a method that specifically kills target cells by combining photosensitizer and irradiation with light at the appropriate wavelength. The natural amino acid, 5-aminolevulinic acid (5-ALA), precursor of endogenous porphyrins in heme biosynthesis pathway. This review summarizes recent progress understanding biosynthetic pathways regulatory mechanisms 5-ALA synthesis biological hosts. effectiveness 5-ALA-aPDI destroying various groups pathogens (viruses, fungi, yeasts, parasites) was presented, but greater attention focused on antibacterial activity this technique. Finally, clinical applications therapies using visible (treatment ulcers disinfection dental canals) were described.

Language: Английский

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