Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(24), P. 11762 - 11773
Published: Jan. 1, 2024
Nanohydroxyapatite
(nHAp)
has
attracted
significant
attention
for
its
tumor
suppression
and
microenvironment
modulation
capabilities.
However,
a
strong
tendency
to
aggregate
greatly
affects
anti-tumor
efficiency.
To
address
this
issue,
hydrogel
platform
consisting
of
thiolated
hyaluronic
acid
(HA-SH)
modified
nanohydroxyapatite
(nHAp-HA)
HA-SH
was
developed
sustained
delivery
nHAp
melanoma
therapy.
The
hydrophilic
negatively
charged
significantly
improved
the
size
dispersion
stability
in
aqueous
media
while
conferring
targeting
effects.
Covalent
sulfhydryl
self-cross-linking
between
nHAp-HA
groups
ensured
homogeneous
matrix
material.
Meanwhile,
modification
conferred
properties
enhanced
cellular
uptake
through
HA/CD44
receptor.
could
effectively
reduce
aggregation
release
orderly
manner.
Antitumor
experiments
showed
that
retained
cytotoxicity
vitro
inhibited
growth
highly
malignant
melanomas
up
78.6%
being
able
induce
differentiation
macrophages
M1
pro-inflammatory
antitumor
phenotype.
This
study
will
broaden
application
Gels,
Journal Year:
2024,
Volume and Issue:
10(11), P. 693 - 693
Published: Oct. 25, 2024
Hydrogels
are
known
for
their
high
water
retention
capacity
and
biocompatibility
have
become
essential
materials
in
tissue
engineering
drug
delivery
systems.
This
review
explores
recent
advancements
hydrogel
technology,
focusing
on
innovative
types
such
as
self-healing,
tough,
smart,
hybrid
hydrogels,
each
engineered
to
overcome
the
limitations
of
conventional
hydrogels.
Self-healing
hydrogels
can
autonomously
repair
structural
damage,
making
them
well-suited
applications
dynamic
biomedical
environments.
Tough
designed
with
enhanced
mechanical
properties,
enabling
use
load-bearing
cartilage
regeneration.
Smart
respond
external
stimuli,
including
changes
pH,
temperature,
electromagnetic
fields,
ideal
controlled
release
tailored
specific
medical
needs.
Hybrid
made
from
both
natural
synthetic
polymers,
combine
bioactivity
resilience,
which
is
particularly
valuable
complex
tissues.
Despite
these
innovations,
challenges
optimizing
biocompatibility,
adjusting
degradation
rates,
scaling
up
production
remain.
provides
an
in-depth
analysis
emerging
technologies,
highlighting
transformative
potential
while
outlining
future
directions
development
applications.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 11, 2025
Nano-drug
delivery
systems
(NDDS)
have
become
a
promising
alternative
and
adjunctive
strategy
for
lung
cancer
(LC)
treatment.
However,
comprehensive
bibliometric
analyses
examining
global
research
efforts
on
NDDS
in
LC
are
scarce.
This
study
aims
to
fill
this
gap
by
identifying
key
trends,
emerging
hotspots,
collaboration
networks
within
the
field
of
LC.
A
total
2452
publications,
spanning
from
1998
2024,
were
extracted
Web
Science
Core
Collection.
The
data
analyzed
using
tools
such
as
VOSviewer,
CiteSpace,
R
package
'bibliometrix'.
analysis
covered
contributions
12,539
researchers
affiliated
with
2689
institutions
across
55
countries,
their
work
published
551
different
journals.
Research
output
has
increased
steadily,
China
United
States
leading
both
publication
volume
impact.
Major
contributors
include
Chinese
Academy
Sciences
Shanghai
Jiao
Tong
University.
International
Journal
Nanomedicine
most
articles,
while
Controlled
Release
ranked
highest
co-citations.
Kamal
Dua
authored
papers,
Maeda,
H.
was
frequently
co-cited
author.
Key
areas
encompass
"active
targeting",
"drug
optimization",
"overcoming
drug
resistance",
"nanocarriers",
"pulmonary
delivery".
Emerging
hotspots
"epithelial
mesenchymal
transition",
"mucus
penetration",
"lipid
nanoparticles",
"hydrogels",
"immune
checkpoint
inhibitors".
analysis,
first
LC,
identifies
targeting"
nanoparticles"
These
findings
provide
essential
insights
guide
future
optimize
treatment
strategies.
Chemistry - A European Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
The
use
of
fluorescent
labels
is
the
most
common
tool
to
visualize
cells.
However,
internalization
dye
molecules
often
modifies
cell
behavior.
In
this
paper
we
demonstrate
that
it
possible
transiently
label
cells
using
a
3D
scaffold,
hydrogel,
covalently
functionalized
with
luminescent
cyclometalated
iridium(III)
complexes.
unique
feature
our
design
complexes
are
emissive
only
when
they
interact
membrane
while
their
emission
quenched
in
water.
We
exploited
perform
real-time
and
staining-free
visualization
imaging.
Iridium
hydrogels
very
weakly
immerged
culture
media.
When
added
them,
iridium
complexes,
linked
gel,
lipophilic
"switches
on"
luminescence
enabling
clear
dynamic,
proliferation.
A
complete
photophysical
biological
study
materials
presented
which
demonstrates
potential
methodology
for
3D-realtime
tracking.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 117118 - 117118
Published: July 14, 2024
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
prevalent
malignant
tumors
in
contemporary
era,
representing
a
significant
global
health
concern.
Early
HCC
patients
have
mild
symptoms
or
are
asymptomatic,
which
promotes
onset
and
progression
disease.
Moreover,
advanced
insensitive
to
chemotherapy,
making
traditional
clinical
treatment
unable
block
cancer
development.
Sorafenib
(SFB)
first-line
targeted
drug
for
with
anti-angiogenesis
anti-tumor
cell
proliferation
effects.
However,
efficacy
SFB
constrained
by
its
off-target
distribution,
rapid
metabolism,
multi-drug
resistance.
In
recent
years,
nanoparticles
based
on
variety
materials
been
demonstrated
enhance
targeting
therapeutic
against
HCC.
Concurrently,
advent
joint
delivery
systems
has
furnished
crucial
empirical
evidence
reversing
This
review
will
summarize
application
nanotechnology
field
over
past
five
years.
It
focus
research
progress
combined
multiple
modalities
treatment.
Gels,
Journal Year:
2024,
Volume and Issue:
10(5), P. 307 - 307
Published: May 1, 2024
Nanostructured
lipid
carriers
(NLCs)
have
the
potential
to
increase
bioavailability
and
reduce
side
effects
of
docetaxel
(DTX).
However,
only
a
small
fraction
nanoparticles
given
intravenously
can
reach
solid
tumor.
In
situ-forming
gels
combined
with
facilitate
local
administration
promote
drug
retention
at
tumor
site.
Injectable
hydrogels
based
on
poloxamer
407
are
excellent
candidates
for
this
hybrid
nanoparticle-hydrogel
system
because
their
thermoresponsive
behavior
biocompatibility.
Therefore,
work
aimed
develop
injectable
containing
NLCs
intratumoral
delivery
DTX.
To
ensure
sterility,
obtained
were
autoclaved
(121
°C
15
min)
after
preparation.
Then,
incorporation
into
impact
steam
sterilization
nanocomposite
evaluated
concerning
sol-gel
transition,
injectability,
physicochemical
stability.
All
formulations
extruded
through
tested
syringe-needle
systems
acceptable
force
(2.2-13.4
N)
(49.5-317.7
N·mm)
injection.
Following
sterilization,
injection
became
easier
in
most
cases,
properties
all
remained
practically
unchanged
according
spectroscopical
thermal
analysis.
The
rheological
evaluation
revealed
that
liquid
25
underwent
rapid
gelation
37
°C.
sterilized
counterparts
gelled
1-2
above
body
temperature,
suggesting
autoclaving
conditions
employed
had
rendered
these
unsuitable
delivery.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 9100 - 9100
Published: Aug. 22, 2024
The
impressive
adhesive
capacity
of
marine
mussels
has
inspired
various
fascinating
designs
in
biomedical
fields.
Mussel-inspired
injectable
hydrogels,
as
a
type
promising
mussel-inspired
material,
have
attracted
much
attention
due
to
their
minimally
invasive
property
and
desirable
functions
provided
by
components.
In
recent
decades,
hydrogels
been
designed
widely
applied
numerous
rational
incorporation
catechol
groups
endows
the
with
potential
exhibit
many
properties,
including
tissue
adhesiveness
self-healing,
antimicrobial,
antioxidant
capabilities,
broadening
applications
this
review,
we
first
give
brief
introduction
adhesion
mechanism
characteristics
hydrogels.
Further,
typical
design
strategies
are
summarized.
methodologies
for
integrating
into
polymers
crosslinking
methods
discussed
section.
addition,
systematically
overview
applications,
focus
on
how
unique
properties
these
benefit
challenges
perspectives
last
This
review
may
provide
new
inspiration
novel
bioinspired
facilitate
application
Drug Delivery,
Journal Year:
2024,
Volume and Issue:
31(1)
Published: Sept. 10, 2024
The
unavoidable
residual
tumor
tissue
from
surgery
and
the
strong
aggressiveness
of
cells
pose
challenges
to
postoperative
treatment
patients,
accompanied
by
in
situ
recurrence
decreased
quality
life.
Therefore,
there
is
an
urgent
need
explore
appropriate
therapeutic
strategies
remove
after
inhibit
metastasis
surgery.
In
recent
years,
with
rapid
development
biomedical
materials,
study
local
delivery
systems
as
agents
has
gradually
attracted
attention
researchers.
Injectable
situ-forming
hydrogel
a
locally
administered
agent
injected
solution
that
can
be
loaded
various
rapidly
gels
form
semi-solid
gel
at
site.
This
type
tightly
fills
surgical
site
covers
irregular
excision
surfaces.
this
paper,
we
review
advances
application
injectable
hydrogels
therapy,
focusing
on
matrix
materials
its
different
types
tumors,
well
discussing
prospects
clinical
application.
