A self-supplied hydrogen peroxide and nitric oxide-generating nanoplatform enhances the efficacy of chemodynamic therapy for biofilm eradication

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 20 - 29

Published: Aug. 22, 2024

Language: Английский

Fenton-like nanoparticles capable of H₂O₂ self-supply and glutathione consumption for chemodynamic and chemotherapy of cancer

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(21), P. 5534 - 5546

Published: Jan. 1, 2024

Chemodynamic therapy (CDT) utilizing the Fenton reaction to convert hydrogen peroxide (H2O2) into cytotoxic hydroxyl radicals (˙OH) has recently drawn extensive interest in tumor treatment. However, therapeutic efficiency of CDT often suffers from high concentrations glutathione (GSH), insufficient endogenous H2O2 and inefficient activity. Herein, a GSH-depleting self-providing nanosystem that can efficiently load copper ions doxorubicin (DOX) (MSN-Cu2+-DOX) induce enhanced chemotherapy is proposed. The results show MSN-Cu2+-DOX could release Cu2+ DOX under acidic conditions. Particularly, both released are available for ˙OH production via Fenton-like CDT. Meanwhile, undergoes reduction Cu+ by depleting overexpressed GSH, thereby enhancing Moreover, not only be used chemotherapy, but also promote generation improve Cu-based reaction. Resultantly, this featuring activity, GSH consumption, self-sufficiency exhibits great antitumor effect with inhibition ratio 93.05%. Overall, study provides promising strategy enhance effective therapy.

Language: Английский

Functionalized ZIF-8 as a versatile platform for drug delivery and cancer therapy: strategies, challenges and prospects

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses the functionalization strategies of ZIF-8 and challenges future developments in ZIF-8-based platforms for drug delivery cancer therapy.

Language: Английский