Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 30, 2025
The
present
investigation
has
introduced
a
new
class
of
isocyanide/acetylene-based
multicomponent
reactions
(IAMCRs).
These
are
robust
technique
for
efficiently
synthesizing
intricate
spiro
architectures
through
zwitterionic
adduct.
coupling
reaction
between
the
"in
situ"
generated
dipoles
isocyanide-acetylenic
ester
adducts
and
3-alkyl-4-arylidene-isoxazol-5(4H)-one
derivative
presents
highly
effective
synthetic
pathway
obtaining
novel
1-oxo-2-oxa-3-azaspiro[4.4]nona-3,6,8-triene
heterocycles.
broad
range
substrates,
standard
experimental
conditions,
straightforward
procedure,
impressive
yields
make
our
catalyst-free
three-component
approach
practical
green,
as
it
remarkably
offers
step-,
time-
cost-effectiveness
based
on
green
metrics.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(22), P. 4835 - 4839
Published: May 29, 2024
A
three-component
cascade
reaction
involving
cyclohexanones,
anilines,
and
diaryl
diselenides
under
metal-free
conditions
is
reported.
The
ortho-selenation
of
cyclohexanones
with
diselenides,
followed
by
sequential
dehydroaromatization
enables
the
preparation
a
variety
o-selanyl
anilines
in
moderate
to
excellent
yields.
This
innovative
transformation
notable
for
its
tolerance
functional
groups
suitable
late-stage
modification
complex
pharmaceuticals.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(9), P. 6117 - 6125
Published: April 24, 2024
The
first
paired
electrolysis-enabled
arylation
of
quinoxalin-2(1H)-ones
was
achieved
using
cyanoarenes
as
the
reagents.
A
variety
3-arylquinoxalin-2(1H)-ones
with
various
important
functional
groups
were
obtained
in
moderate
to
good
yields
under
metal-
and
chemical
oxidant-free
conditions.
With
a
pair
reductive
oxidative
processes
occurring
among
substrates
reaction
intermediates,
power
consumption
can
be
dramatically
reduced.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(6), P. 4113 - 4119
Published: March 6, 2024
The
first
example
of
an
electrochemical
multicomponent
synthesis
selenium-containing
compounds
with
inexpensive
and
abundant
elemental
selenium
as
the
selenating
reagent
was
developed.
A
variety
selenazol-2-amines
were
constructed
in
high
yields
good
functional
group
tolerance
under
metal-free
chemical
oxidant-free
conditions.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
study
describes
a
pioneering
visible-light-induced
phosphine-catalyzed
halogen-atom
transfer
(XAT)
strategy
that
heralds
new
era
in
the
difunctionalization
of
[1.1.1]propellane.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(8), P. 5371 - 5381
Published: March 29, 2024
A
facile
and
eco-friendly
photoinduced
dehydrogenative
amination
of
quinoxalin-2(1H)-ones
with
aliphatic
amines
without
any
metal,
strong
oxidant,
photocatalyst
has
been
established
for
the
first
time.
This
reaction
proceeding
efficiently
air
as
sole
oxidant
at
room
temperature
obtains
a
wide
range
3-aminoquinoxaline-2(1H)-ones
in
high
yields
excellent
functional
group
tolerance.
The
mechanistic
studies
show
an
interesting
involvement
photosensitizer,
which
eliminates
requirement
external
photocatalysts.
