Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 30, 2025
The
present
investigation
has
introduced
a
new
class
of
isocyanide/acetylene-based
multicomponent
reactions
(IAMCRs).
These
are
robust
technique
for
efficiently
synthesizing
intricate
spiro
architectures
through
zwitterionic
adduct.
coupling
reaction
between
the
"in
situ"
generated
dipoles
isocyanide-acetylenic
ester
adducts
and
3-alkyl-4-arylidene-isoxazol-5(4H)-one
derivative
presents
highly
effective
synthetic
pathway
obtaining
novel
1-oxo-2-oxa-3-azaspiro[4.4]nona-3,6,8-triene
heterocycles.
broad
range
substrates,
standard
experimental
conditions,
straightforward
procedure,
impressive
yields
make
our
catalyst-free
three-component
approach
practical
green,
as
it
remarkably
offers
step-,
time-
cost-effectiveness
based
on
green
metrics.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(14), P. 1637 - 1643
Published: April 3, 2024
Comprehensive
Summary
Although,
great
achievements
have
been
made
in
the
synthesis
of
heterocycles
using
radical
addition/cyclization
strategy,
developing
versatile
alkyl
precursors,
especially
non‐stabilized
long
chain
radicals
for
this
strategy
still
remains
a
huge
challenge.
Herein,
we
report
an
efficient
annulation
cascade
reaction
between
cyclosulfonium
salts
and
alkenes
sulfur‐containing
N
‐heterocycles
by
visible
light/copper
catalysis
under
mild
conditions.
The
C—S
bond
cleavage/radical
delivers
variety
corresponding
containing
aryl
thioether
motifs
with
good
functional
group
tolerance.
Significantly,
current
system
could
be
used
late‐stage
functionalization
complex
bioactive
molecules.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(19), P. 3860 - 3865
Published: Jan. 1, 2024
The
aminophosphinoylation
of
alcohols
with
amines
and
H-phosphine
oxides
provides
an
efficient
mild
approach
to
access
various
α-aminoalkylphosphine
in
good
yields
tolerance
functional
groups
using
H
2
O
as
a
clean
solvent.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(11), P. 7727 - 7740
Published: May 10, 2024
The
synthesis
of
thiazolines,
thiazolidines,
and
thiazolidinones
has
been
extensively
studied,
due
to
their
biological
activity
related
neurodegenerative
diseases,
such
as
Parkinson's
Alzheimer's,
well
antiparasitic
antihypertensive
properties.
closely
thiazolidin-2-imines
have
studied
less,
efficient
strategies
for
synthesizing
them,
mainly
based
on
the
reaction
propargylamines
with
isothiocyanates,
explored
less.
use
one-pot
approaches,
providing
modular,
straightforward,
sustainable
access
these
compounds,
also
received
very
little
attention.
Herein,
we
report
a
novel,
one-pot,
multicomponent,
copper-catalyzed
among
primary
amines,
ketones,
terminal
alkynes,
toward
bearing
quaternary
carbon
centers
five-membered
ring,
in
good
excellent
yields.
Density
functional
theory
calculations,
combined
experimental
mechanistic
findings,
suggest
that
copper(I)-catalyzed
between
situ-formed
isothiocyanates
proceeds
lower
energy
barrier
pathway
leading
S-cyclized
product,
compared
N-cyclized
one,
chemo-
regioselective
formation
5-exo-dig
thiazolidin-2-imines.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(24), P. 5196 - 5201
Published: June 10, 2024
A
novel
strategy
for
incorporating
a
trifluoroacetyl
functionality
into
range
of
structurally
varied
unsaturated
bonds
was
developed
by
using
PhI(OCOMe)2
as
an
oxidant
with
masked
trifluoroacyl
reagent
radical
precursor.
The
oxidative
decarboxylation
the
precursor
followed
tandem
process
provides
versatile
access
to
5-exo-trig
cyclization
N-arylacrylamides,
direct
C(sp2)–H
trifluoroacetylation
quinolines,
isoquinoline,
2H-indazole,
and
quinoxalin-2(1H)-ones,
C(sp)–H
alkynes.
This
protocol
is
characterized
mild
reaction
conditions,
operational
simplicity,
broad
functional
group
compatibility.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 30, 2025
The
present
investigation
has
introduced
a
new
class
of
isocyanide/acetylene-based
multicomponent
reactions
(IAMCRs).
These
are
robust
technique
for
efficiently
synthesizing
intricate
spiro
architectures
through
zwitterionic
adduct.
coupling
reaction
between
the
"in
situ"
generated
dipoles
isocyanide-acetylenic
ester
adducts
and
3-alkyl-4-arylidene-isoxazol-5(4H)-one
derivative
presents
highly
effective
synthetic
pathway
obtaining
novel
1-oxo-2-oxa-3-azaspiro[4.4]nona-3,6,8-triene
heterocycles.
broad
range
substrates,
standard
experimental
conditions,
straightforward
procedure,
impressive
yields
make
our
catalyst-free
three-component
approach
practical
green,
as
it
remarkably
offers
step-,
time-
cost-effectiveness
based
on
green
metrics.
