Nanocarrier Design Based on the Tumor Microenvironment Target: A Pivotal Direction in Nano-Drug Delivery Strategies DOI
Zirui Zhang,

Xinyuan Kong,

Zhijie Wang

et al.

Diseases & Research, Journal Year: 2024, Volume and Issue: 4(0), P. 1 - 8

Published: Jan. 1, 2024

Language: Английский

Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

Citations

7
Metabolic vulnerabilities in cancer: A new therapeutic strategy DOI
Mohamed El‐Tanani, Syed Arman Rabbani,

Yahia El‐Tanani

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 201, P. 104438 - 104438

Published: July 6, 2024

Language: Английский

Citations

4
Protein-functionalized and intrinsically radiolabeled [188Re]ReOx nanoparticles: advancing cancer therapy through concurrent radio-photothermal effects DOI Creative Commons
Sanchita Ghosh, Apurav Guleria,

Sourav Patra

et al.

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Enhancing therapeutic effectiveness is crucial for translating anticancer nanomedicines from laboratory to clinical settings. In this study, we have developed radioactive rhenium oxide nanoparticles encapsulated in human serum albumin ([188Re]ReOx-HSA NPs) concurrent radiotherapy (RT) and photothermal therapy (PTT), aiming optimize treatment outcomes. [188Re]ReOx-HSA NPs were synthesized by a controlled reduction of 188ReO4− HSA medium extensively characterized. The effect was demonstrated vitro murine melanoma (B16F10) cell line. vivo SPECT/CT imaging, autoradiography biodistribution studies performed after intratumoral injection tumor-bearing C57BL/6 mice. potential combined RT PTT also the aforesaid mice model. (size 4–6 nm) with high colloidal radiochemical stability. Upon laser (808 exposure on B16F10 cells incubated NPs, only < 20% alive demonstrating efficacy under Uniform dose distribution retention radiolabeled tumor volume observed via imaging studies. Tumor growth model significantly arrested ~ 1.85 MBq simultaneous irradiation, synergistic benefit PTT. These results demonstrate that intrinsically having unique features such as effects favorable nuclear decay characteristics RT/PTT, hold great promise translation.

Language: Английский

Citations

0
Computational investigations on anti-cancer drug solubility in supercritical solvent for efficient cancer therapy DOI
Ziming Wang,

Yu Wan,

Hongxia Li

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 404, P. 124864 - 124864

Published: May 1, 2024

Language: Английский

Citations

3
Nanocarrier Design Based on the Tumor Microenvironment Target: A Pivotal Direction in Nano-Drug Delivery Strategies DOI
Zirui Zhang,

Xinyuan Kong,

Zhijie Wang

et al.

Diseases & Research, Journal Year: 2024, Volume and Issue: 4(0), P. 1 - 8

Published: Jan. 1, 2024

Language: Английский

Citations

0