A Self‐Accelerating Naphthalimide‐Based Probe Coupled with Upconversion Nanoparticles for Ultra‐Accurate Tri‐Mode Visualization of Hydrogen Peroxide

Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)

Published: Jan. 19, 2024

Abstract The design and development of ultra‐accurate probe is great significance to chemical sensing in complex practical scenarios. Here, a self‐accelerating naphthalimide‐based with fast response high sensitivity toward hydrogen peroxide (H 2 O ) designed. By coupling the specially selected upconversion nanoparticles (UCNPs), an colorimetric‐fluorescent‐upconversion luminescence (UCL) tri‐mode platform constructed. Owing promoted reaction process, this demonstrates rapid (< 1 s), ultra‐low detection limit (4.34 nM), superb anti‐interferent ability even presence > 21 types oxidants, explosives, metallic salts, daily compounds, colorful or fluorescent substances. In addition, effectiveness further verified by sponge‐based chip loaded UCNPs/probe recognizing trace H vapor from interferents three characteristic colors existing simultaneously. proposed visualization expected open up brand‐new methodology for sensing.

Language: Английский

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Recent advances in self‐immobilizing fluorescent probes for in vivo imaging

Smart Molecules, Journal Year: 2024, Volume and Issue: 2(3)

Published: Aug. 23, 2024

Abstract In situ precise detection of bioactive molecules with high sensitivity and spatiotemporal resolution is essential for studying physiological events disease diagnosis. The utilization versatile fluorescent probes in fluorescence imaging offers a powerful tool vivo biomarkers closely associated pathological conditions. However, the dynamic behavior leading to rapid clearance small molecule from regions interest severely compromises their potential imaging. Notably, self‐immobilizing that selectively recognize diseased tissues while improving retention enrichment enable accurate high‐fidelity this review, we aim summarize strategies employed recent advances performance precision using techniques. Lastly, discuss prospects challenges promote further development application more delicate probes.

Language: Английский

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Noninvasive Diagnosis of Kidney Dysfunction Using a Small-Molecule Manganese-Based Magnetic Resonance Imaging Probe

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(8), P. 3318 - 3328

Published: Feb. 14, 2024

Contrast-enhanced magnetic resonance imaging (CE-MRI) is a promising approach for the diagnosis of kidney diseases. However, safety concerns, including nephrogenic systemic fibrosis, limit administration gadolinium (Gd)-based contrast agents (GBCAs) in patients who suffer from renal impairment. Meanwhile, nanomaterials meet biosafety concerns because their long-term retention body. Herein, we propose small-molecule manganese-based probe Mn-PhDTA as an alternative to GBCAs assess insufficiency first time. was synthesized via simple three-step reaction with total yield up 33.6%, and gram-scale synthesis can be realized. has r1 relaxivity 2.72 mM–1 s–1 at 3.0 T superior kinetic inertness over Gd-DTPA Mn-EDTA dissociation time 60 min presence excess Zn2+. In vivo vitro experiments demonstrate good stability biocompatibility. unilateral ureteral obstruction rats, provided significant MR signal enhancement, enabled distinguishing structure changes between normal damaged kidneys, evaluated function different injured stages. could act potential MRI agent candidate replacement early detection dysfunction analysis disease progression.

Language: Английский

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Target Discovery Driven by Chemical Biology and Computational Biology

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Target identification is crucial for drug screening and development because it can reveal the mechanism of action ensure reliability accuracy results. Chemical biology, an interdisciplinary field combining chemistry assist in this process by studying interactions between active molecular compounds proteins their physiological effects. It also help predict potential targets or candidates, develop new biomarker assays diagnostic reagents, evaluate selectivity range to reduce risk off-target biology achieve these goals using techniques such as changing protein thermal stability, enzyme sensitivity, structure applying probes, isotope labeling mass spectrometry. Concurrently, computational employs a diverse array models targets. This approach offers innovative avenues repurposing existing drugs. In paper, we review reported chemical identifying different types that provide valuable insights target discovery.

Language: Английский

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Imaging-guided Companion Theranostics: Ushering in A New Era of Personalized Cancer Care

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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A Sequentially Activated Probe for Imaging of Superoxide Anion and Peroxynitrite in PC12 Cells under Oxidative Stress

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(18), P. 7138 - 7144

Published: April 27, 2024

Superoxide anion (O2·–) and peroxynitrite (ONOO–), two important oxidants under oxidative stress, coexist in complex cell organism systems, playing crucial roles various physiological pathological processes, particularly neurodegenerative diseases. Despite the absence of robust molecular tools capable simultaneously visualizing O2·– ONOO– biosystems, relationship between these species remains understudied. Herein, we present sequentially activated fluorescent probe, DHX-SP, which exhibits exceptional selectivity sensitivity toward ONOO–. This probe enables precise imaging living PC12 cells stress conditions using distinct fluorescence signal combinations. Furthermore, DHX-SP has ability to visualize changes levels during ferroptosis Parkinson's disease model. These findings establish a connection crosstalk phosphorus group stress.

Language: Английский

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Recent advances in molecular and nanoparticle probes for fluorescent bioanalysis

Nano Research, Journal Year: 2024, Volume and Issue: 17(7), P. 6443 - 6474

Published: April 12, 2024

Language: Английский

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Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy

Chemical & Biomedical Imaging, Journal Year: 2024, Volume and Issue: 2(5), P. 313 - 330

Published: April 17, 2024

Antisense oligonucleotide (ASO) represents a class of practical tools for targeting undruggable oncogenes with several candidates currently undergoing clinical investigation. The advancement antisense therapeutics necessitates comprehensive approaches evaluating their efficacy and improving accuracy. Molecular imaging techniques offer qualitative quantitative means to assess at the molecular, cellular, in vivo levels, as well elucidate biodistribution pharmacokinetics. These capabilities play pivotal role enhancing therapeutic evaluation efficiency. This review systematically explores current landscape ASO delivery by leveraging synergistic combination vehicles enhance distribution accumulation tumor sites thereby optimizing outcomes.

Language: Английский

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Fluorescent tetrazolylpyrene unnatural nucleoside in sensing BSA protein

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 116290 - 116290

Published: Jan. 1, 2025

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Large-Scale Synthesis of Non-Ionic Bismuth Chelate for Computed Tomography Imaging in Vivo

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123122 - 123122

Published: Jan. 24, 2025

Language: Английский

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