A naphthalimido-based fluorescent probe for HOCl sensing with excellent lysosome-targeted performance

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141393 - 141393

Published: Jan. 1, 2025

Language: Английский

---

Development of a hybrid rhodamine-hydrazine NIR fluorescent probe for sensitive detection and imaging of peroxynitrite in necrotizing enterocolitis model

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 152, P. 107729 - 107729

Published: Aug. 22, 2024

Language: Английский

---

Novel BODIPY-based NIR fluorescent probe with appropriate Stokes shift for diagnosis and treatment evaluation of epilepsy via imaging ONOO− fluctuation

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 423, P. 136766 - 136766

Published: Oct. 11, 2024

Language: Английский

---

An ingenious near-infrared fluorescent probe for detection of viscosity in biosystems and beverages

Microchemical Journal, Journal Year: 2025, Volume and Issue: 209, P. 112734 - 112734

Published: Jan. 10, 2025

Language: Английский

---

Unveiling Dynamic Alterations of Lipid Droplet Polarity during NAFLD-Triggered Lipophagy Utilizing a Far-Red Fluorescent Probe with large Stokes Shift

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 422, P. 136509 - 136509

Published: Aug. 23, 2024

Language: Английский

---

Monitoring Glutathione Content of the Endoplasmic Reticulum under Scrap Leather-Induced Endoplasmic Reticulum Stress via an Endoplasmic Reticulum-Targeted Two-Photon Fluorescent Probe

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(45), P. 18132 - 18140

Published: Oct. 30, 2024

Maintaining tissue homeostasis necessitates the coordinated efforts of various cell types to regulate inflammation. Endoplasmic reticulum (ER) stress, a hallmark inflammation, exacerbates pathology in human diseases. Glutathione (GSH), pivotal regulator cellular redox balance, controls disulfide bond formation ER, thereby shielding cells from oxidative stress. In this study, we developed two-photon fluorescent probe, ER-GSH, with specific ER targeting and demonstrated its high sensitivity rapid response GSH. Experiments conducted on BV2 mice model neuroinflammation induced by scrap leather revealed that inflammatory reactions led stress substantial reduction GSH levels. Notably, anti-inflammatory drug NS-398 effectively inhibited inflammation maintaining These findings underscore potential therapeutic significance modulating levels alleviate impact neuroinflammation.

Language: Английский

---

A Golgi apparatus-targeted ratiometric fluorescent probe for HOCl and its applications for anti-inflammatory evaluation of Dachengqi Decoction

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 336, P. 126026 - 126026

Published: March 12, 2025

Language: Английский

---

Targeting Sub-Cellular Organelles for Boosting Precision Photodynamic Therapy

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.

Language: Английский

---

Vanin-1-Activated Fluorescent Probe for Real-Time In Vivo Imaging of Inflammatory Responses Across Multiple Tissue Types

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Vanin-1 is a pantetheine hydrolase that plays key role in inflammatory diseases. Effective tools for noninvasive, real-time monitoring of are lacking, largely due to background fluorescence interference existing probes. To address this issue, we developed dual-modal fluorescent and colorimetric probe, MB-Van1, detect with high sensitivity selectivity. MB-Van1 has structure optimized exhibit nearly zero fluorescence, resulting signal-to-noise ratio enables the accurate detection activity various biological tissues. In vitro experiments demonstrated had limit as low 0.031 ng/mL mode. We successfully employ observe elevated levels tissues mouse models rheumatoid arthritis (RA), drug-induced liver injury (DILI), nonsteroidal anti-inflammatory drug (NSAID) enteropathy models, within only 5 min. This advancement provides novel approach dynamic changes during inflammation, offering new strategies early diagnosis therapeutic assessment other related

Language: Английский

---

Application of a near-infrared viscosity-responsive fluorescent probe for lysosomal targeting in fatty liver mice

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 155, P. 108162 - 108162

Published: Jan. 13, 2025

Language: Английский

---