Phage‐Templated Synthesis of Targeted Photoactive 1D‐Thiophene Nanoparticles DOI Creative Commons
Paolo Emidio Costantini, Roberto Saporetti,

Marika Iencharelli

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Thiophene‐based nanoparticles (TNPs) are promising therapeutic and imaging agents. Here, using an innovative phage‐templated synthesis, a strategy able to bypass the current limitations of TNPs in nanomedicine applications is proposed. The phage capsid decorated with oligothiophene derivatives, transforming virus 1D‐thiophene nanoparticle (1D‐TNP). A precise control shape/size obtained exploiting well‐defined morphology refactored filamentous M13 phage, engineered by display selectively recognize Epidermal Growth Factor Receptor (EGFR). tropism maintained also after bioconjugation thiophene molecules on its capsid. Moreover, 1D‐TNP proved highly fluorescent photoactive, generating reactive oxygen species through both type I II mechanisms. phototheranostic properties this platform investigated biosystems presenting increasing complexity levels, from vitro cancer cells 2D 3D architectures, vivo tissue‐like model organism Hydra vulgaris . showed photocytotoxicity at picomolar concentrations, ability deeply penetrate spheroids tissues. Collectively results indicate that synthesis organic represents general strategy, exploitable many diagnostic fields based targeted light mediated cell ablation.

Language: Английский

Recent advances in near-infrared organic photosensitizers for photodynamic cancer therapy DOI
Nguyễn Văn Nghĩa, Nguyen Minh Viet, Phạm Thị Mai Hương

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This minireview highlights recent developments in near-infrared organic photosensitizers for photodynamic cancer therapy. The challenges and future prospects of this promising research field are also discussed.

Language: Английский

Citations

0
Phosphole-Based Fluorescent Biomaterials for Imaging and Therapy DOI Creative Commons

Zeyan Zhuang,

Jianqing Li, Ben Zhong Tang

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Language: Английский

Citations

0
Endogenous Near‐Infrared Chemiluminescence: Imaging‐Guided Non‐Invasive Thrombolysis and Anti‐Inflammation Based on a Heteronuclear Transition Metal Complex DOI Creative Commons
Ziwei Wang, Bo Zhu, Wei Nie

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Conventional therapy to treat thrombi (blood clots) has significant limitations: i) inflammation; ii) bleeding side effects; iii) re-embolisation, and iv) in situ that are not visible. Here it is reported Cu2Ir nanoparticles (NPs) with a Cu-coordinated tetraphenylporphyrin (TPP) core cyclometalated Ir(C^N)2(N^N) substituents integrate long-lived near-infrared (NIR) chemiluminescence (CL) imaging, photothermal (PTT) photodynamic (PDT) for thrombolysis, antioxidant anti-inflammatory properties. Based on density functional theory calculations the chemiluminescent reaction site between TPP peroxynitrite (ONOO-) confirmed first time. The presence of transition metal significantly improves properties TPP. Upon specific activation by ONOO-, NPs exhibited more than 30-fold NIR CL intensity NPs, luminescence lasted 60 min allowing precise long-lasting dynamic tracking thrombi. achieved non-invasive safe thrombolytic triggered irradiation at signaling site. 72.3% blood reperfusion obtained nearly complete restoration flow, re-embolism prevented mouse carotid artery model. Furthermore, scavenged excess reactive oxygen/nitrogen species (RONS) reduced inflammatory factors. hold promise as single-molecule strategy diagnosing treating diseases associated thrombosis.

Language: Английский

Citations

0
Phage‐Templated Synthesis of Targeted Photoactive 1D‐Thiophene Nanoparticles DOI Creative Commons
Paolo Emidio Costantini, Roberto Saporetti,

Marika Iencharelli

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Thiophene‐based nanoparticles (TNPs) are promising therapeutic and imaging agents. Here, using an innovative phage‐templated synthesis, a strategy able to bypass the current limitations of TNPs in nanomedicine applications is proposed. The phage capsid decorated with oligothiophene derivatives, transforming virus 1D‐thiophene nanoparticle (1D‐TNP). A precise control shape/size obtained exploiting well‐defined morphology refactored filamentous M13 phage, engineered by display selectively recognize Epidermal Growth Factor Receptor (EGFR). tropism maintained also after bioconjugation thiophene molecules on its capsid. Moreover, 1D‐TNP proved highly fluorescent photoactive, generating reactive oxygen species through both type I II mechanisms. phototheranostic properties this platform investigated biosystems presenting increasing complexity levels, from vitro cancer cells 2D 3D architectures, vivo tissue‐like model organism Hydra vulgaris . showed photocytotoxicity at picomolar concentrations, ability deeply penetrate spheroids tissues. Collectively results indicate that synthesis organic represents general strategy, exploitable many diagnostic fields based targeted light mediated cell ablation.

Language: Английский

Citations

0