Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1555 - 1555
Published: Dec. 5, 2024
The
article
is
devoted
to
the
creation
of
enzymatic
nanoreactors
based
on
polystyrene-block-poly(acrylic
acid)
(PS-b-PAA)
copolymers
containing
bioscavengers
capable
neutralizing
toxic
esters
both
in
body
and
environment.
Block
different
amphiphilicity,
hydrophilicity
molecular
weights
were
synthesized
characterized
using
gel
permeation
chromatography,
NMR
UV
spectroscopy.
Polymeric
nanocontainers
absence
presence
human
butyrylcholinesterase
made
by
film
hydration
dynamic
light
scattering
microscopy
methods.
Enzyme
activity
was
determined
Ellman
method.
For
first
time,
factors
that
need
be
taken
into
account
for
effective
PS-b-PAA
are
presented.
data
obtained
open
up
possibility
nanoreactor
use
future
vivo
bioscavenger
studies.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
tutorial
review
presents
the
development
of
advanced
immunomodulatory
hydrogels
strategically
designed
to
address
chronic
inflammation
through
their
intrinsic
properties.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(7), P. 915 - 915
Published: July 9, 2024
This
study
utilized
Aspergillus
flavus
to
produce
selenium
nanoparticles
(Se-NPs)
in
an
environmentally
friendly
and
ecologically
sustainable
manner,
targeting
several
medicinal
applications.
These
biosynthesized
Se-NPs
were
meticulously
characterized
using
X-ray
diffraction
(XRD),
Fourier-transform
infrared
(FT-IR)
spectroscopy,
transmission
electron
microscope
(TEM),
UV–visible
spectroscopy
(UV),
revealing
their
spherical
shape
size
ranging
between
28
78
nm.
We
conducted
further
testing
of
evaluate
potential
for
biological
applications,
including
antiviral,
anticancer,
antibacterial,
antioxidant,
antibiofilm
activities.
The
results
indicate
that
could
be
effective
against
various
pathogens,
Salmonella
typhimurium
(ATCC
14028),
Bacillus
pumilus
14884),
Staphylococcus
aureus
6538),
Clostridium
sporogenes
19404),
Escherichia
coli
8739),
subtilis
6633).
Additionally,
the
exhibited
anticancer
activity
three
cell
lines:
pancreatic
carcinoma
(PANC1),
cervical
cancer
(Hela),
colorectal
adenocarcinoma
(Caco-2),
with
IC50
values
177,
208,
216
μg/mL,
respectively.
demonstrated
antiviral
HSV-1
HAV,
achieving
inhibition
rates
66.4%
15.1%,
respectively,
at
maximum
non-toxic
concentration,
while
also
displaying
antioxidant
properties.
In
conclusion,
by
A.
present
a
promising
avenue
biomedical
applications
safe
usage.
Mini-Reviews in Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
24(19), P. 1723 - 1745
Published: April 27, 2024
Abstract::
Neurological
disorders
present
a
formidable
challenge
in
modern
medicine
due
to
the
intricate
obstacles
set
for
brain
and
multipart
nature
of
genetic
interventions.
This
review
article
delves
into
promising
realm
nanoparticle-based
gene
therapy
as
an
innovative
approach
addressing
intricacies
neurological
disorders.
Nanoparticles
(NPs)
provide
multipurpose
podium
conveyance
therapeutic
genes,
offering
unique
properties
such
precise
targeting,
enhanced
stability,
potential
bypass
blood-brain
barrier
(BBB)
restrictions.
comprehensive
exploration
reviews
current
state
nanoparticle-mediated
disorders,
highlighting
recent
advancements
breakthroughs.
The
discussion
encompasses
synthesis
nanoparticles
from
various
materials
their
conjugation
emphasizing
flexibility
design
that
contributes
specific
tissue
targeting.
abstract
also
addresses
low
immunogenicity
these
stability
circulation,
critical
factors
successful
delivery.
While
NP-based
is
vast,
challenges
gaps
knowledge
persist.
lack
extensive
clinical
trials
leaves
questions
about
safety
side
effects
unanswered.
Therefore,
this
emphasizes
need
further
research
validate
applications
NP-mediated
address
nanosafety
concerns.
In
conclusion,
emerges
avenue
pursuit
effective
treatments
advocates
continued
efforts
bridge
existing
gaps,
unlocking
full
paving
way
transformative
solutions
health.
Expert Review of Vaccines,
Journal Year:
2024,
Volume and Issue:
23(1), P. 535 - 545
Published: April 26, 2024
Zebrafishes
represent
a
proven
model
for
human
diseases
and
systems
biology,
exhibiting
physiological
genetic
similarities
having
innate
adaptive
immune
systems.
However,
they
are
underexplored
vaccinology,
vaccine
development,
testing.
Here
we
summarize
gaps
challenges.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 25, 2025
Advanced
gastric
cancer
remains
a
significant
global
health
challenge,
with
limited
therapeutic
options
available.
In
contrast,
immunotherapy
have
emerged
as
promising
alternatives,
offering
greater
potency
in
treating
advanced
cancer.
However,
the
development
of
novel
and
efficient
immunotherapeutic
strategy
is
crucial
to
enhance
body's
immune
response
against
This
study
developed
single-injection
peptide
hydrogel-based
nanovaccine
therapy
for
treatment.
The
utilizes
RADA32
hydrogel,
which
sensitive
metal
ion
concentration,
encapsulate
manganese
ions
HPPS
nanovaccines.
nanovaccines
contain
antigen
CpG-ODN,
designed
activate
both
toll-like
receptor
9
(TLR9)
cGAS-STING
signaling
pathways
antigen-presenting
cells.
design
aims
facilitate
stable
sustained
release
nanovaccine,
thereby
enhancing
effective
recognition
antigens.
efficacy
system
was
confirmed
using
model
OVA
cancer-specific
MG7-related
peptide.
results
demonstrated
that
effectively
activated
response,
leading
enhanced
activation
TLR9
cells
observed
highlighting
potential
this
approach
stimulate
robust
presents
clinical
anti-tumor
vaccine
administration,
prevention
treatment
provides
convenient
method
could
potentially
be
expanded
other
types
cancer,
providing
versatile
platform
immunotherapy.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 14, 2025
Nanodiamonds
(NDs)
display
several
attractive
features
rendering
them
useful
for
medical
applications
such
as
drug
delivery.
However,
the
interactions
between
NDs
and
immune
system
remain
poorly
understood.
Here,
we
investigated
amino-,
carboxyl-,
poly(ethylene
glycol)
(PEG)-terminated
with
respect
to
primary
human
cells.
We
applied
cytometry
by
time-of-flight
(CyToF)
assess
impact
on
peripheral
blood
mononuclear
cells
at
single-cell
level,
observed
an
expansion
of
plasmacytoid
dendritic
(pDCs)
which
are
critically
involved
in
antiviral
responses.
Subsequent
experiments
demonstrated
that
were
actively
internalized,
leading
a
vigorous
type
I
interferon
response
involving
endosomal
Toll-like
receptors.
ND-NH2
ND-COOH
more
potent
than
ND-PEG,
evidenced
using
TLR
reporter
cell
lines.
Computational
studies
interacted
ligand-binding
domains
TLR7
TLR9
high
affinity
though
this
was
less
pronounced
ND-PEG.
varying
surface
functionalities
also
readily
taken
up
macrophages.
To
gain
further
insight,
performed
RNA
sequencing
monocyte-like
line
exposed
NDs,
found
phagosome
maturation
pathway
significantly
affected.
Indeed,
evidence
lysosomal
hyperacidification
obtained
macrophages
NDs.
Moreover,
line,
impinge
autophagic
flux.
did
not
affect
viability
any
types
studied.
This
study
has
shown
subvert
antiviral-like
response.
implications
only
delivery
but
anticancer
vaccines
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: June 3, 2025
The
ability
to
completely
repair
or
regenerate
injured
tissues
organs
and
restore
their
functionality
has
long
been
a
goal
of
humankind.
advancements
in
tissue
engineering
regenerative
medicine
have
made
this
conceivable.
With
the
precisely
manipulate
nanoscale
architectures
for
designing
biomaterials,
DNA
nanotechnology
emerged
as
groundbreaking
technique
medicine.
DNA-based
nanostructures
are
well-suited
directing
cellular
interactions,
delivering
therapeutic
drugs,
mimicking
extracellular
matrix
components
due
exceptional
biocompatibility,
programmability,
molecular
recognition
capabilities.
Recent
developments
demonstrated
that
nanodevices
can
be
used
administer
drugs
growth
factors
controlled
manner,
well
enhance
cell
adhesion,
proliferation,
differentiation.
Furthermore,
capacity
respond
biological
stimuli
enables
dynamic
adaptable
regeneration
techniques.
This
review
highlights
latest
advances
applications,
its
benefits
over
traditional
potential
future
pathways
clinical
translation.
Frontiers in Drug Delivery,
Journal Year:
2024,
Volume and Issue:
4
Published: Aug. 8, 2024
This
review
article
explores
the
potential
of
engineering
antigen-presenting
cells
(APCs)
for
immunotherapy
autoimmune
diseases.
It
discusses
various
strategies
modifying
APCs
to
induce
antigen-specific
tolerance,
thereby
mitigating
responses.
The
covers
recent
advancements
in
APC
techniques,
including
genetic
modification
and
nanoparticle-based
approaches,
evaluates
their
efficacy
preclinical
models
clinical
trials.
Additionally,
challenges
future
directions
development
APC-based
immunotherapies
autoimmunity
–
other
forms
cell-based
are
discussed.
Along
this
direction,
(
i
)
describes
APCs,
modification,
nanoparticle
delivery
systems,
ex
vivo
manipulation
techniques;
ii
selection
target
antigens
design
immunotherapies,
iii
reviews
used
evaluate
safety
engineered
inducing
tolerance.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Abstract
While
chemotherapy
and
radiotherapy
may
alleviate
symptoms
prolong
survival
in
patients
with
advanced
gastric
cancer,
their
efficacy
is
constrained.
In
contrast,
immunotherapies,
including
immune
checkpoint
inhibitors,
T-cell
transfer
therapy,
therapeutic
vaccines,
demonstrate
greater
potency
treating
cancer.
This
study
developed
a
single-injection
peptide
hydrogel-based
nanovaccine
therapy
for
cancer
treatment.
The
employs
RADA32
hydrogel,
sensitive
to
metal
ion
concentration,
encapsulating
manganese
ions
HPPS
nanovaccines
(containing
antigen
peptides
CpG-ODN)
facilitate
stable,
sustained
release
of
the
nanovaccine.
strategy
activates
both
toll-like
receptor
9
cGAS-STING
signaling
pathways
antigen-presenting
cells,
enhancing
body's
effective
recognition
response
antigens.
system's
was
confirmed
using
model
OVA
cancer-specific
MG7-related
peptide.
approach
offers
novel
clinical
anti-tumor
vaccine
administration
be
applicable
preventing
