NADPH Oxidases‐Inspired Reactive Oxygen Biocatalysts with Electron‐Rich Pt Sites to Potently Amplify Immune Checkpoint Blockade Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Clinical immune checkpoint blockade (ICB)‐based immunotherapy of malignant tumors only elicits durable responses in a minority patients, primarily due to the highly immunosuppressive tumor microenvironment. Although inducing immunogenic cell death (ICD) through reactive oxygen biocatalyst represents an attractive therapeutic strategy amplify ICB, currently reported biocatalysts encounter insurmountable challenges achieving high ROS‐generating activity induce potent ICD. Here, inspired by natural catalytic characteristics NADPH oxidases, design efficient, robust, and electron‐rich Pt‐based redox centers on non‐stoichiometric W 18 O 49 substrates (Pt─WO x ) serve as bioinspired potently activate ICD, which eventually enhance cancer amplifies ICB‐based is reported. These studies demonstrate that Pt─WO exhibits rapid electron transfer capability can promote formation low oxophilic Pt for superior biocatalysis, enables ‐based inducers trigger endoplasmic reticulum stress directly stimulate amplifying anti‐PD‐L1‐based ICB therapy. This provides straightforward engineer also opens up new avenue create efficient ICD primary/metastatic treatments.

Language: Английский

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Stabilized Oxygen Vacancy Chemistry toward High-Performance Layered Oxide Cathodes for Sodium-Ion Batteries

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Anionic redox has emerged as a transformative paradigm for high-energy layered transition-metal (TM) oxide cathodes, but it is usually accompanied by the formation of anionic redox-mediated oxygen vacancies (OVs) due to irreversible release. Additionally, external factor-induced OVs (defined intrinsic OVs) also play pivotal role in physicochemical properties TM oxides. However, an in-depth understanding interplay between and corresponding regulation mechanism dynamic evolution still missing. Herein, we disclose strong interrelationship these demonstrate that presence TMO

Language: Английский

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Insights into the doping functions on redox chemistry of layered Ni-rich cathodes

Journal of Energy Chemistry, Journal Year: 2024, Volume and Issue: 102, P. 386 - 412

Published: Nov. 17, 2024

Language: Английский

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Regulating the Charge Distribution of Oxygen by High-Entropy Doping to Stabilize Single-Crystal Ni-Rich Cathode Materials

ACS Applied Energy Materials, Journal Year: 2024, Volume and Issue: 7(16), P. 6961 - 6971

Published: Aug. 5, 2024

Single-crystal Ni-rich ternary cathode materials (811), with their comprehensive advantage of high energy density and low manufacturing cost, have been considered the most promising for Li-ion batteries. Due to strong O-p/TM-d covalent hybridization, complete oxidation Ni ions during electrochemical cycling is often accompanied by inevitable oxygen loss, resulting in an irreversible surface phase transition, accumulated lattice stress, poor thermal stability. Considering fact that introducing heteroatoms into traditional doping systems can alter electron distribution around coordinated oxygen, compositionally complex based on high-entropy may a more significant effect stabilizing oxygen. Herein, strategy was applied design synthesize single-crystal NCM811 cathodes (HE811) through molten salt method. Compared 811, HE811 show excellent initial Coulombic efficiency 90.74% at 0.2C deliver higher capacity retention 80.79% after 300 cycles 1C between 2.8 4.3 V. Owing doping, densities multidopants are increased, inhibiting excessive improving stability TMO6 coordination structures. This work could provide insights effects modulating charge high-energy-density long-term cycling.

Language: Английский

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Achievable dual-strategy to stabilize Li-rich layered oxide interface by a one-step wet chemical reaction towards long oxygen redox reversibility

Journal of Energy Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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