Probing the Structure and Orientation of Carboxylic Acid-Terminated Self-Assembled Monolayers DOI

Ahlam R. M. Alharbi,

Tanglaw Roman, Abdulrahman S. Alotabi

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(36), P. 18925 - 18941

Published: Aug. 27, 2024

Self-assembled monolayers (SAMs), such as alkanethiols (AT), are widely used functional coatings or interfaces between different materials. There is an assumption that the arrangement and alignment of hydrocarbon chains in films made from carboxyl-terminated similar to those alkanethiols. Here, structure outermost layer near-surface region SAMs formed various lengths has been analyzed. The chemical composition samples was measured using X-ray photoelectron spectroscopy (XPS) angle-resolved XPS (AR-XPS), allowing film thickness. Metastable induced (MIES) a surface analytical tool sensitive only for conjunction with density theory (DFT) calculations provided insights into topmost layer, showing it consists mainly backbone SAM-forming molecules. Through combining AR-XPS concentration depth profiles measurement can be shown tend favor gauche orientation, enabling interactions groups.

Language: Английский

Recent Developments in Stimuli-Responsive Polymer for Emerging Applications: A Review DOI Creative Commons
Abdelrahman K. A. Khalil, Yeit Haan Teow, Mohd Sobri Takriff

et al.

Results in Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 103900 - 103900

Published: Jan. 1, 2025

Language: Английский

Citations

5
Cytochrome P450 electrochemical biosensors transforming in vitro metabolism testing – Opportunities and challenges DOI Creative Commons

C. Vieira,

Marcela A. Segundo, Alberto N. Araújo

et al.

Bioelectrochemistry, Journal Year: 2025, Volume and Issue: 163, P. 108913 - 108913

Published: Jan. 22, 2025

The ability of the living world to flourish in face constant exposure dangerous chemicals depends on management a widespread group enzymes known as heme-thiolate monooxygenases or cytochrome P450 superfamily. About three-quarters all reactions determining metabolism endogenous compounds, those carried foods, taken drugs, even synthetic discarded into environment depend their catalytic performance. chromatographic and (photo)luminometric methods routinely used predictive analytical tools laboratories have significant drawbacks ranging from limited shelf-life reagents, use substrates, laborious tedious procedures for highly sensitive detection. In this review, alternative electrochemical biosensors using bio-element are emphasized main aspects well regarding implementation usefulness. Despite various schemes proposed implementation, reports real applications scant several reasons, including low reaction rates, broad substrate specificity, uncoupling occurrence, need expensive electron transfer partners promote transfer. Finally, prospect future developments is introduced, focusing integrating miniaturized systems with techniques, alongside optimizing enzyme immobilization electrode modifications improve enzymatic stability enhance sensor reliability. This progress represents crucial step towards creation portable that mimic human physiological responses, supporting precision medicine approach.

Language: Английский

Citations

0
Molecular sieve redefines SPR sensible range for “win-win” dual functions to enhance the sensitization and anti-fouling DOI
Yangyang Zhou, Jingyao Wu,

Wenbo Cui

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 61, P. 102670 - 102670

Published: Feb. 15, 2025

Language: Английский

Citations

0
Novel High‐Throughput Electrochemical Detection of Staphylococcus Aureus, Bacillus Cereus, or Micrococcus Luteus Using AuNPs@Ti3C2Tz Functionalized with Sandwich Peptides DOI Open Access
Jaehwan Park, My−Van Tieu, Thi Xoan Hoang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Affinity‐based electrochemical biosensors hold promise for detecting pathogenic bacteria in environmental applications. This study focuses on gram‐positive bacteria, which can cause fatal infections and are a major global mortality factor. An biosensor platform using high‐throughput 16‐channel gold disk electrodes (16‐GDEs) inspired by bio‐microelectromechanical systems (BioMEMS) is developed, it incorporates nanocomposite (AuNPs@Ti 3 C 2 T z ) with sandwich peptide structures to enhance electroconductivity biological antifouling. Using AuNPs@Ti ‐coated 16‐GDEs, sensitive ( Staphylococcus aureus , Bacillus cereus or Micrococcus luteus constructed validated fresh‐water samples spiking showed linear correlations between normalized peak current logarithmic concentrations of the target (adjusted R‐square ≥ 0.93). A single containing S. M. B. also exhibiting specific responses without any cross‐reactivity real samples. enabled simultaneous detection multiple analytes (500 CFU mL⁻¹) be applied detect analyte suitable pair. The strategy implement quantitative real‐time polymerase chain reaction (RT‐qPCR) adaptive sensing device successfully bacteria. nanocomposite‐enabled 16‐GDEs offers valuable tool clinical diagnostics.

Language: Английский

Citations

0
Functionalized screen-printed electrodes for non-invasive detection of vascular-endothelial cadherin in extracellular vesicles DOI Creative Commons
William Meza-Morales,

Sahimy Ayus-Martinez,

Jesus Jimenez-Osorio

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(16), P. 12609 - 12621

Published: Jan. 1, 2025

Detection of endothelial biomarker vascular-endothelial cadherin (CD144) on saliva-derived extracellular vesicles using a gold screen-printed electrode biosensor functionalized with mercaptoundecanoic acid and anti-CD144 antibody.

Language: Английский

Citations

0
Modelling Prospects of Bio-Electrochemical Immunosensing Platforms DOI Creative Commons
Mansi Gandhi

Electrochem, Journal Year: 2024, Volume and Issue: 5(2), P. 146 - 161

Published: April 24, 2024

Electrochemistry is a hotspot in today’s research arena. Many different domains have been extended for their role towards the Internet of Things, digital health, personalized nutrition, and/or wellness using electrochemistry. These advances led to substantial increase power and popularity electroanalysis its expansion into new phases environments. The recent COVID-19 pandemic, which turned our lives upside down, has helped us understand need miniaturized electrochemical diagnostic platforms. It also accelerated mobile wearable, implantable sensors as telehealth systems. major principle behind these platforms immunoassays, help overshadowing classical gold standard methods (reverse transcriptase polymerase chain reaction) terms accuracy, time, manpower, and, most importantly, economics. groups endeavoured use bio-electrochemical tools overcome limitations assays (in accessibility, portability, response time). This review mainly focuses on technologies used immunosensing platforms, fabrication requirements, mechanistic objectives, techniques involved, subsequent output signal amplifications tagged non-tagged system. combination various (optical spectroscopy, Raman scattering, column chromatography, HPLC, X-ray diffraction) enabled construction high-performance electrodes. Later review, combinations utilization will be explained platform along with chemical bonding later part article. Furthermore, market study real prototypes elaborately discussed.

Language: Английский

Citations

1
Self-assembly Monolayer Fluorescent Probe on Alumina Substrate Enabling Highly Sensitive Detection of Arsenite Ions in Groundwater DOI
Yangyang Han, Xinyue Chang,

Ningshuang Gao

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 424, P. 136882 - 136882

Published: Nov. 8, 2024

Language: Английский

Citations

1
Incorporation of phenylcarbonyl groups in the sidechain: A tool to induce ordered assembly of peptides on surfaces DOI

Mrinal Kalita,

Khushboo Yadav,

Archana Archana

et al.

Journal of Peptide Science, Journal Year: 2024, Volume and Issue: unknown

Published: June 19, 2024

The possibility of introducing various functionalities on peptides with relative ease allows them to be used for molecular applications. However, oligopeptides prepared entirely from proteinogenic amino acids seldom assemble as ordered structures surfaces. Therefore, sidechain modifications that can increase the intermolecular interactions without altering constitution a given peptide become an attractive route self-assembling We find replacing phenylalanine residues unusual have phenylcarbonyl sidechains in increases formation self-assembly highly pyrolytic graphite surface. Peptides containing modified provided extended long-range assemblies, while analogous failed form assemblies. X-ray crystallographic analysis bulk these and reveal such do not alter secondary structure crystals. It also reveals hydrogen bonding interaction through facilitates growth graphite.

Language: Английский

Citations

0
Quantitative electrochemical and SEIRA characterization of mercaptosuccinic acid monolayer on gold surface DOI

ZhangFei Su,

Agata Królikowska,

Ryan Seenath

et al.

Electrochimica Acta, Journal Year: 2024, Volume and Issue: 499, P. 144715 - 144715

Published: July 14, 2024

Language: Английский

Citations

0
Probing the Structure and Orientation of Carboxylic Acid-Terminated Self-Assembled Monolayers DOI

Ahlam R. M. Alharbi,

Tanglaw Roman, Abdulrahman S. Alotabi

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(36), P. 18925 - 18941

Published: Aug. 27, 2024

Self-assembled monolayers (SAMs), such as alkanethiols (AT), are widely used functional coatings or interfaces between different materials. There is an assumption that the arrangement and alignment of hydrocarbon chains in films made from carboxyl-terminated similar to those alkanethiols. Here, structure outermost layer near-surface region SAMs formed various lengths has been analyzed. The chemical composition samples was measured using X-ray photoelectron spectroscopy (XPS) angle-resolved XPS (AR-XPS), allowing film thickness. Metastable induced (MIES) a surface analytical tool sensitive only for conjunction with density theory (DFT) calculations provided insights into topmost layer, showing it consists mainly backbone SAM-forming molecules. Through combining AR-XPS concentration depth profiles measurement can be shown tend favor gauche orientation, enabling interactions groups.

Language: Английский

Citations

0