Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 497 - 517
Published: Jan. 1, 2024
Chemical Science, Journal Year: 2024, Volume and Issue: 15(6), P. 2047 - 2054
Published: Jan. 1, 2024
From a single N-confused dithiahexaphyrin ligand, five mono- and bis-Pd( ii ) complexes have been synthesized, the absorption aromaticity can be modulated by Pd( coordination, macrocycle contraction ancillary ligands.
Language: Английский
Citations
8
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142225 - 142225
Published: March 1, 2025
Language: Английский
Citations
0
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(5), P. 2365 - 2374
Published: April 15, 2024
Antimicrobial resistance has emerged as a global threat to the treatment of infectious diseases. Antibacterial photodynamic therapy (aPDT) is promising alternative approach and highly suitable for cutaneous bacterial infections through topical applications. aPDT relies on light-responsive compounds called photosensitizer (PS) dyes, which generate reactive oxygen species (ROS) when induced by light, thereby killing cells. Despite several previous studies in this area, molecular details targeting cell death mediated PS dyes are poorly understood. In study, we further investigate antibacterial properties two water-soluble Sn(IV) tetrapyridylporphyrins that were quaternized with methyl hexyl groups (1 2). follow-up demonstrate Sn(IV)-porphyrins can be photoexcited blue light (a 427 nm LED) exhibit various levels bactericidal activity against both Gram-(+) Gram-(−) strains bacteria. Using localization fluorescence microscopy, show 2 targets membrane more effectively than 1 exhibits comparatively higher activity. multiple reporters, photoactivation results extensive collateral damage cells including DNA cleavage, damage, delocalization central systems necessary growth division. summary, investigation provides deep insights into mechanism Sn(IV)-porphyrins. Moreover, our offers new method evaluating PS, may inspire discovery enhanced
Language: Английский
Citations
3
Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1340, P. 142536 - 142536
Published: April 29, 2025
Language: Английский
Citations
0
Photochem, Journal Year: 2023, Volume and Issue: 3(3), P. 313 - 326
Published: June 30, 2023
A Sn(IV) meso-tetra(4-methylthiolphenyl) N-confused porphyrin (4-Sn) complex was prepared to facilitate a comparison of the photophysicochemical and singlet oxygen photosensitiser properties series complexes meso-4-methylthiolphenyl-substituted porphyrin, corrole, chlorin, porphyrin. 4-Sn has an unusually high quantum (ΦΔ) yield 0.88, markedly higher than ΦΔ values other in this series. Thorlabs M660L4 LED (280 mW · cm−2) used study photodynamic activity Sn-4 against MCF-7 cancer cell line through irradiation at 660 nm for 30 min. The IC50 value calculated be 1.4 (± 0.8) µM, lower previously reported rest Photodynamic antimicrobial also determined Staphylococcus aureus Escherichia coli, found deactivate both Gram-(+) Gram-(−) bacteria despite absence cationic charges on ligand structure.
Language: Английский
Citations
4
Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: unknown, P. 104431 - 104431
Published: Dec. 1, 2024
Lysosomes are pivotal in diverse physiological phenomena, encompassing autophagy, apoptosis, and cellular senescence. The demand for precise tumors treatment has led to the development of specific lysosome-targeting probes capable elucidating lysosomal dynamics facilitating targeted cell death. In this research, we report synthesis characterization a novel benzopyrrolidinyl-substituted silicon phthalocyanine (Py-SiPc), designed selective lysosome labeling Fluorescence imaging-guided vitro photodynamic therapy. Furthermore, encapsulated Py-SiPc within biocompatible nanocarrier, dipalmitoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE), create water-soluble nanoparticles (DSPE@Py-SiPc). These exhibit exceptional capabilities, as evidenced by bioimaging techniques. Upon exposure laser irradiation, DSPE@Py-SiPc efficiently induces production reactive oxygen species, impairing function triggering lysosomal-mediated system emerges promising photosensitizer cancer therapy, heralding new era phototherapy.
Language: Английский
Citations
1
Molecules, Journal Year: 2023, Volume and Issue: 28(10), P. 4030 - 4030
Published: May 11, 2023
A series of tetraarylchlorins with 3-methoxy-, 4-hydroxy- and 3-methoxy-4-hydroxyphenyl meso-aryl rings (1-3-Chl) their Sn(IV) complexes (1-3-SnChl) were synthesized characterized so that potential utility as photosensitizer dyes for use in photodynamic therapy (PDT) antimicrobial chemotherapy (PACT) can be assessed. The photophysicochemical properties the assessed prior to vitro PDT activity studies against MCF-7 breast cancer cells through irradiation Thorlabs 625 or 660 nm LED 20 min (240 280 mW·cm-2). PACT performed both planktonic bacteria biofilms Gram-(+) S. aureus Gram-(-) E. coli upon LEDs 75 min. heavy atom effect ion results relatively high singlet oxygen quantum yield values 0.69-0.71 1-3-SnChl. Relatively low IC50 between 1.1-4.1 3.8-9.4 µM obtained 1-3-SnChl LEDs, respectively, during studies. also found exhibit significant Log10 reduction 7.65 >3.0, respectively. demonstrate merit further depth study photosensitizers biomedical applications.
Language: Английский
Citations
3
Photodiagnosis and Photodynamic Therapy, Journal Year: 2023, Volume and Issue: 44, P. 103815 - 103815
Published: Sept. 29, 2023
Language: Английский
Citations
3
ChemMedChem, Journal Year: 2024, Volume and Issue: 19(21)
Published: July 17, 2024
Abstract In recent years, Sn(IV) porphyrins have proven to be excellent choice as photosensitizers for photodynamic therapy. This work reports the synthesis, characterization and activity of four high‐valent fluorinated having different numbers F‐atoms in peripheral meso ‐phenyl groups viz . (Dichloro) ‐tetrakis(4‐fluorophenylporphyrinato)stannic(IV), [Sn(IV)FTPP(Cl) 2 ] or Sn1 ; ‐tetrakis(2,4‐difluorophenylporphyrinato)stannic(IV), [Sn(IV)2,4‐FTPP(Cl) Sn2 ‐tetrakis(2,6‐difluorophenylporphyrinato)stannic(IV), [Sn(IV)2,6‐FTPP(Cl) Sn3 ‐tetrakis(4‐trifluoromethylphenylporphyrinato)stannic(IV), [Sn(IV)CF 3 TPP(Cl) Sn4 The solid‐state structure has been determined by single crystal X‐ray diffraction analysis. increasing number attached positions porphyrin framework results increase their lipophilicity, singlet oxygen quantum yield (Φ Δ ) photocytotoxicity A549 (human lung adenocarcinoma cells), MCF‐7 MDA‐MB‐231 breast adenocarcinoma) cells. predominantly localize mitochondria light‐induced cell death cells occur primarily via apoptosis.
Language: Английский
Citations
0
Journal of Porphyrins and Phthalocyanines, Journal Year: 2024, Volume and Issue: 28(07), P. 469 - 486
Published: July 1, 2024
Silver nanoparticle (AgNP) conjugates of two series P(V) and Ga(III) corroles with 4-thiomethylphenyl- (1-P V Cor-AgNPs 1-Ga III Cor-AgNPs), thien-3-yl- (2-P 2-Ga thien-2-yl- (3-P 3-Ga Cor-AgNPs) 5-bromothien-2-yl- (4-P 4-Ga meso-aryl rings have been synthesized characterized, so that their in vitro photodynamic antimicrobial chemotherapy (PACT) properties could be investigated against S. aureus E. coli. The 4-P Cor complexes are reported for the first time this context, while 1-3-P Corr 1-3-Ga were previously during a study therapy (PDT) activity gold MCF-7 breast cancer cells. heavy atom effects bromine atoms result increases singlet oxygen quantum yield values to 0.59 0.72, respectively, from 0.47 0.69 3-P Cor. Conjugation AgNPs results further slight due an external effect significantly enhances photostability dyes. 1-4-P found higher PACT activities than 1-4-Ga lower aggregation since there is trans-axial ligation. Complete eradication coli Log[Formula: see text] reduction 7.04 was achieved 20μg.mL[Formula: 3-4-P 3-4-Ga despite difficulties typically encountered context Gram-([Formula: bacteria.
Language: Английский
Citations
0